Sunday, March 19

2:45 PM – 4:15 PM

Organizers:
Michael Lehmicke, MSc, Johnson&Johnson
Judd Day, PhD, Exponent

Additive Manufacturing (AM), including 3D printing and other additive techniques, covers the range from a rapid prototyping method and a research tool to a valid manufacturing technique for orthopaedic implants and instrumentation. This is an area of increasing interest among ORS members. AM allows research groups to develop ideas and implement both experimental and clinical research programs more easily than in the past. The technology can be easy to use but there are many parameters and considerations that go into getting reproducible results.

This workshop will provide an overview of how additive manufacturing techniques may be applied to create orthopedic implants and instrumentation from a variety of materials for different applications. Workshop attendees will gain an understanding of how additive manufacturing may apply to their own research as well as future translational applications.

Application of 3D Printing to Total Joint Design & Evaluation
Peter Walker, PhD, New York University

From Allografts to 3D Printed Scaffolds: Advances in Bone Tissue Engineering
Hani Awad, PhD, University of Rochester

FDA Resources and Guidance for Additive Manufacturing
James Coburn, MS, US – Food and Drug Administration

This workshop does not qualify for CME.

4:30 PM – 5:30 PM

Presented by Materialise

3D printing is transforming orthopedic healthcare and improving patient treatment in a variety of ways, as researchers and clinicians are continually striving to improve the standard of care. During the hands-on workshop, attendees will learn how to convert medical image data into a highly accurate 3D model of a patient’s anatomy.

Attendees will be instructed on how to

1) Segment medical image data

2) Design a custom implant

3) Prepare a part for 3D printing

*Attendees need to register for the workshop in order to receive a trial version of the Mimics Innovation Suite software that needs to be downloaded.

**Attendees are welcome to attend and follow along without downloading the software.

This workshop does not qualify for CME.

This Workshop is Full

Organized by the ORS Women’s Leadership Forum

Organizers:
Robin Queen, PhD, FACSM, Virginia Tech
Susan V. Bukata, MD, University of California Los Angeles

Osteoarthritis (OA) is a chronic, debilitating condition affecting many adults worldwide.  It affects 1 in 5 adults in the United States and the risk of developing OA by age 85 approaches 50%.  In 2009, $185.5 billion was spent in the US for medical care related to OA, representing more than 1% of the entire gross domestic product (GDP) for that year.  Despite widespread prevalence of the disease and tremendous costs to the healthcare system, very little remains understood about the etiology and progression of osteoarthritis.  Further, no definitive therapeutic options have been established for OA, and care remains focused on symptom relief with eventual progression for many patients to total joint replacement.  Pain and disability resulting from arthritis remains a dominant complaint of most adults over age 65 and a limiting factor for activity and quality of life for many of these patients.  Research is seeking to better understand the biology, biomechanics, and clinical interactions that combine to create the disease of osteoarthritis.  This workshop will review the current state of the art in biology, biomechanics, and clinical medicine in the care of osteoarthritis and discuss the emerging research goals and frontiers for this prevalent and costly disease.

The Biology of Aging Cartilage and Development of OA:  What Do We Know About the Process?
Anna Spagnoli, MD, Rush University

Current Clinical Treatments for OA: Pills, Injections, And Metal.  Does Anything Make a Difference?
Constance Chu, MD, Stanford University

How Do We Know it Works:  Measuring Functional Outcomes in Response to OA Interventions?
Stephen Messier, PhD, Wake Forest University

2:45 PM – 4:15 PM

hs_logo_blueOrganized by The Hip Society and ORS

Organizers:
Harry Rubash, MD, Massachusetts General Hospital
Kevin Bozic, MD, MBA, University of Texas at Austin

Hip fracture is a common event with the 3rd highest cost in American medicine today. It carries the highest mortality rate of any common orthopaedic diagnosis and also has the highest 30-day readmission. There have been few improvements in care over the past 30 years and this situation makes hip fracture an important orthopaedic condition to study so that we can improve upon patient outcomes.

Research Gaps in Basic and Translational Research
William Macaulay, MD, Columbia University

Research Gaps in Clinical Health Services Research
Stephen Kates, MD, Virginia Commonwealth University

2:45 PM – 4:15 PM

ks_logo_blueOrganized by The Knee Society and ORS

Organizers:
Timothy Wright, PhD, Hospital for Special Surgery
Guoan Li, PhD, Massachusetts General Hospital

Instability is among the major causes of dissatisfaction and failure in total knee arthroplasty (TKA) and can be related to patient actors, surgical technique, and implant design. The problem of recreating adequate joint stability with TKA is confounded by the complex static constraints provided by the ligaments and joint capsule and by the active contribution of muscle forces. The workshop will serve to establish where we are in understanding instability and where we need to go to prevent and treat instability by addressing the following questions:

  • What is the scope of the clinical problem and what current treatments exist?
  • What is the multiplanar target for a stable knee and how can computational modeling be used to improve TKA function?
  • What postoperative outcome measures link joint stability and function to patient satisfaction? 

What is the Scope of the Clinical Problem of Instability in TKA and What Current Treatments Exist?
Douglas Dennis, MD, Colorado Joint Replacement

What is the Multiplanar Target for a Stable Knee and How Can Computational Modeling be Used to Improve TKA Function?
Paul Rullkoetter, PhD, University of Denver

What Postoperative Outcome Measures Link Joint Stability and Function to Patient Satisfaction?
Scott Banks, PhD, University of Florida

Monday, March 20

7:30 AM – 9:00 AM

A workshop based on the ORS/AAOS symposium: Tackling Joint Disease by Understanding Crosstalk between Cartilage and Bone, April 2016

Organizers:
Oran D. Kennedy, PhD, New York University
Tamara Alliston, PhD, University of California San Francisco

It is now widely accepted that osteoarthritis (OA) is not limited to articular cartilage but is a disease of the entire joint. While there are treatments to reduce pain associated with OA, there are no treatments that reverse cartilage degeneration. This highlights the need for early diagnosis, prior to degeneration of cartilage, and early treatment options. Magnetic resonance image (MRI) abnormalities known as bone marrow lesions (BMLs) have been identified as an early indicator and/or contributor to cartilage degeneration. This workshop has assembled an excellent panel of speakers to address this topic from a clinical, biological and bioengineering perspective. They will present and discuss the emerging data linking BMLs to knee pathologies, and the basic science behind their potential contribution to OA initiation and progression. There will also be discussions of potential ways to therapeutically target the basic mechanisms that underpin the early stages of disease. This workshop will finish with a statement of important ‘burning questions’ that must be addressed to better understand this problem.

Bone Marrow Lesions in Osteoarthritis
David Felson, MD, Boston University

Bone Cartilage Crosstalk: A Biological Perspective
David Findlay, PhD, University of Adelaide Hospital

The Role of Microdamage, and Bone Turnover, in Osteoarthritic Joint Crosstalk
Christopher Hernandez, PhD, Cornell University

7:30 AM – 9:00 AM

termis_logo_1462x693Organized by the Tissue Engineering and Regenerative Medicine International Society (TERMIS) and ORS

Organizers:
Dimitrios Zeugolis, PhD, NUI Galway
Mauro Alini, PhD, AO Foundation

We have entered the era of biofunctional biomaterials. These are materials that are used to not only provide mechanical support, but to also positively interact with the host and promote functional repair and regeneration, largely due to their cargo (e.g. cells, biologics, drugs). Cell-based therapies require removal of cells from their optimal in vivo tissue context and propagation in vitro to attain suitable cell numbers. However, bereft of their optimal in vivo tissue niche, cells lose their phenotype, function and therapeutic potential. In vitro microenvironment modulators, such as bioreactors, surface topography, substrate rigidity, oxygen tension, are essential in maintaining permanently differentiated cell phenotype and/or directing stem cells towards specific lineages. Gene therapy offers new solutions in the clinical management of orthopaedic conditions, where traditional surgical or medicinal approaches fail to recapitulate native tissue function. Although recent data clearly demonstrate the beneficial effect of gene transfer in bone, cartilage, tendon and intervertebral disk, numerous studies have also raised concerns with respect to safety of such therapeutic approaches. This symposium will elucidate recent advancements and shortfalls in the fields of biomaterials, bioreactors and gene delivery for orthopaedic applications.

Bioreactors for Musculoskeletal Research
Martin Stoddart, PhD, AO Foundation

Gene Therapy for Musculoskeletal Pathophysiologies
Christopher Evans, PhD, Mayo Clinic

Biomimetic Scaffolds for Musculoskeletal Clinical Indications
Alicia El Haj, PhD, Keele University

7:30 AM – 9:00 AM

hs_logo_blueOrganized by The Hip Society and ORS

Organizers:
Harry Rubash, MD, Massachusetts General Hospital
Young-Min Kwon, MD, PhD, Massachusetts General Hospital

Adverse local tissue reactions (Pseudotumors, ALVAL, ALTR) due to tribocorrosion of modular taper junctions in contemporary THA are emerging as an important reason for failure requiring revision surgery. The clinical presentation of tribocorrosion include unexplained pain in THA patients with CoCr femoral head-neck modularity as well as patients with ‘dual taper’ femoral stems with interchangeable neck-stem modularity. This workshop will highlight clinical challenges in diagnosis and treatment of patients with tribocorrosion of contemporary THA, review up-to-date evidence and to identify the areas for future research.

Tribocorrosion in THA 2017: What’s New?
Joshua J. Jacobs, MD, Rush Medical Center

Do Taper Materials and Designs Matter?
Jeremy L. Gilbert, PhD, FBSE, Clemson University

How to Optimize Clinical Evaluation of Taper Corrosion: Risk Stratification Approach
Young-Min Kwon, MD, PhD, Massachusetts General Hospital

7:30 AM – 9:00 AM

posna-logo-final-300dpiOrganized by the Pediatric Orthopaedic Society of North America (POSNA) and ORS

Organizer:
Jonathan G. Schoenecker, MD, PhD, Vanderbilt Children’s Hospital

Pediatric orthopaedic surgeons treat a variety of conditions that include traumatic injuries, developmental and genetic skeletal manifestations, and musculoskeletal infections. Additionally, pediatric orthopaedic surgeons regularly encounter premature skeletal degeneration from pathological (such as osteogenesis imperfecta, cerebral palsy, or Duchenne’s muscular dystrophy) or environmental (such as diet, obesity, and vitamin D deficiency) causes.

Therefore, there is a significant need for pharmaceuticals designed to:

1) Prevent infection
2) Provide analgesia
3) Prevent musculoskeletal degeneration
4) Enhance musculoskeletal regeneration
5) Prevent complications from coagulation/inflammation

This workshop will provide a broad overview of the common therapeutics employed in pediatric orthopaedics within these categories. Specific detail will provide members of the ORS key information regarding areas of clinical significance for which existing pharmaceuticals are effective, the complications of current pharmaceuticals and to highlight areas where novel therapies are needed.

Pediatric Bone Degeneration:  Current Concepts and Therapies:  Lessons Learned from Osteogenesis Imperfect and Disuse Osteopenia
Michelle Caird, MD, University of Michigan

Pediatric Bone Regeneration:  Current Concepts and Therapies:  Lessons Learned from Neurofibromatosis
Benjamin Alman, MD, Duke University

Pediatric Bone Metaplasia:  Bone Where You Don’t Want It:  Current Concepts and Therapies:  Lessons Learned from FOP and Myopathies
Jonathan Schoenecker, MD, PhD, Vanderbilt

Tuesday, March 21

8:00 AM – 9:30 AM

Organizers:
Scott Rodeo, MD, Hospital for Special Surgery
Jeremy Mao, PhD, Columbia University

In musculoskeletal medicine, Platelet-Rich Plasma (PRP) is used as interventional treatments for arthritis (intra-articular injections), rotator cuff repair, focal articular cartilage defects, carpal tunnel syndrome, fracture repair, acute muscle injuries and intervertebral disk degeneration.  In this workshop, several therapeutic examples will be provided.

Current Status of PRP Use in Sports Medicine
Scott Rodeo, MD, Hospital for Special Surgery

Precision Assessment of PRP for the Treatment of Early Osteoarthritis
Constance Chu, MD, Stanford University

PRP Proteomics: The Whole and the Sum of Parts
Jeremy Mao, PhD, Columbia University

8:00 AM – 9:30 AM

Organizers:
Bingyun Li, PhD, West Virginia University
Thomas Webster, PhD, Northeastern University

The dramatically increased incidence of drug-resistant bacterial strains has made the choices of drugs for infection treatment and control increasingly limited and more expensive. Modern medical procedures, including orthopaedic implantations, likely would be accompanied by a much greater risk of developing a difficult-to-treat or untreatable antibiotic resistant infection. Controlling the development and spread of antibiotic resistance is a top national security and public health priority in the US. Funding agencies have been calling for efforts to stimulate innovative research to reduce drug resistance. This workshop will highlight the drug discovery and mechanisms of antimicrobial resistance, cutting-edge immunotherapeutic approaches, clinical translational potential, and the challenges and opportunities in nanomedicine in reducing biomaterial-associated orthopaedic infection.

Emerging Immunotherapeutic Approaches Against Biomaterial-Associated Infection
Bingyun Li, PhD, West Virginia University

Nanotechnology in Drug-Resistant Biomaterials Infection: Past, Present, and Future
Thomas Webster, PhD, Northeastern University

Pathogenesis of Drug-Resistant Bacteria
Dacheng Ren, PhD, Syracuse University

Drug Discovery and Antibiotic Resistance: Challenges and Opportunities
Stuart B. Goodman, MD, Stanford University Medical Center

8:00 AM – 9:30 AM

Organized by the ORS Women’s Leadership Forum

Organizer:
Sophie Verrier, PhD, AO Foundation

Bone repair is a complex mechanism that involves many well-orchestrated events. It is widely accepted that blood vessels and blood flow brings oxygen and nutrients, but cells and specific molecular factors are also crucial in this processes. Impaired vascularization often occurs following trauma as well as or in specific health conditions (e.g. diabetes), can compromise the course of bone repair leading to delayed healing, mal union or non-union which results in an increase in patient burden and related healthcare costs.  Ensuring an adequate blood supply for bone healing still constitutes a clinical challenge and is therefore a clinical therapeutic target.

This workshop will first give insight into the clinical problems associated with poor or no vascularization, and the current clinical methods used to improve vascularization.

In addition, this workshop will facilitate an exchange of knowledge and stimulate discussion between renowned keynote speakers, scientists and clinicians at all career levels with an interest in bone healing.

Vascularization and Bone Healing: Limits and Solutions From a Clinician Perspective
Theodore Miclau, MD, Orthopaedic Trauma Institute

Cellular Key Players in Angiogenesis –The Tissue Engineering Approach
Sabine Fuchs, PhD, University Schleswig-Holstein

Is VEGF the Key Factor for Bone Healing and Regeneration? (Regenerative Approach)
Louis C Gerstenfeld, PhD, Boston University

8:00 AM – 9:30 AM

Organizers:
Yang Xia, PhD, Oakland University
Eric Darling, PhD, Brown University

Chondrocytes and their pericellular matrix (PCM) in articular cartilage are organized as chondrons, which are responsible for the maintenance of the extracellular matrix (ECM) of cartilage over its lifetime. Chondrocytes in their native environment receive constant loading externally, which plays a critical role in regulating their metabolic activities. The functional (biomechanical) properties of the chondrons can be studied by the application of external loading, either to a whole-thickness tissue or to isolated chondrons. Understanding the deformation of chondrons and their ECM, both collectively and individually, will improve our understanding regarding how external force is transmitted via these matrices to the cells, and how these matrices protect the cells during loading. Commonly, optical microscopies and other advanced techniques such as scanning probe microscopy are used in such investigation. This workshop aims to summarize the new development in the technology and latest results in the functional properties of the chondrocytes in cartilage, and to discuss possible applications based on the recent studies. Three presentations are planned, ranging from the functional studies of chondrons that are in situ in their native ECM by optical imaging without staining, probing of the chondrons and chondrocytes directly by micropipette and atomic force microscopy, to measuring dynamic cell deformations and cell signaling in intact joints loaded by muscular contraction using two-photon excitation microscopy. 

Functional Imaging of Chondrocytes in Cartilage by Light Microscopies
Yang Xia, PhD, Oakland University

Physical Probing of Chondrocytes and Their Peri- and Extra-Cellular Matrices
Eric Darling, PhD, Brown University

Dynamic In Situ and In Vivo Chondrocyte Mechanics and Signaling
Walter Herzog, PhD, University of Calgary

Wednesday, March 22

7:30 AM – 9:00 AM

Organizers:
Joel D. Boerckel, PhD, University of Notre Dame
Ralph Marcucio, PhD, University of California San Francisco

Bones develop through multicellular differentiation programs that enable progressive assembly of hierarchical structures and complex cell-cell and cell-matrix interactions that are required for the formation of function bone tissue, capable of volumetric growth, dynamic adaptation to mechanical demands, and scar-free repair. While the regulatory cascades that control bone development are becoming increasingly clarified, recapitulating the efficiency of development for post-natal bone regeneration remains a challenge. This workshop will bring together tissue engineers and basic biologists to foster cross-talk over concepts and approaches for mutual benefit and will highlight the technological and conceptual advances that have enabled the emergence of development-inspired tissue engineering, and will feature cutting-edge, transformative science from leaders in the field and educate attendees on novel interdisciplinary approaches to advance our field.

Developmental Bone Biology: History, Current Concepts, and Approaches
Ling Qin, PhD, University of Pennsylvania

Engineering Development-mimetic Microenvironments with Biomaterials
Eben Alsberg, PhD, Case Western Reserve University

Applications of Bone Development in Bone Tissue Engineering
Ralph Marcucio, PhD, University of California San Francisco

7:30 AM – 9:00 AM

Organizers:
Christopher Mendias, ATC, PhD, University of Michigan
Richard Lovering, PT, PhD, University of Maryland

The purpose of this workshop is to introduce scientists who have an interest in skeletal muscle research to the basics of contractile and mechanical properties measurements of skeletal muscle tissue. The workshop will have a didactic portion that will cover the fundamental theories of muscle mechanics, and the basics of performing and analyzing in vitro and in vivo measurements of skeletal muscle mechanics. There will be equipment available at the end of the workshop for attendees to gain hands on experience in performing these measurements.

Fundamentals of Skeletal Muscle Mechanics
Christopher Mendias, PhD, ATC, University of Michigan

Performing In Vitro and In Vivo Measurements of Skeletal Muscle Contractile and Mechanical Properties
Richard Lovering, PhD, PT, University of Maryland

Samuel Ward, PhD, PT, University of California San Diego
Dr. Ward will not be speaking. He will be available to assist with the didactic sessions

Part 2: Technology Based Workshop
Presented by Aurora Scientific

This workshop aims to educate members of the society about the various techniques and instruments which presently exist to make functional measurements of active and passive stress and strain in isolated tissue.  Discussion will focus on experimental methods, outcomes and why these techniques are a useful tool to have in your laboratory.  Techniques for measuring stress and strain in connective tissue will also be discussed.

This workshop does not qualify for CME.

7:30 AM – 9:00 AM

Organized by the Musculoskeletal Tumor Society (MSTS) and ORS

Organizers:
Wakenda Tyler, MPH, MD, University of Rochester
Francis Lee, MD, PhD, Yale University

Implant related infections in joint reconstruction are among the most devastating complications in orthopaedic surgery. The cost to the healthcare system and the patient associated morbidity demand ardent focus on the prevention and early diagnosis of these infections. This workshop will focus on three key areas of prevention and diagnosis. First, an update on the clinical evidence for systemic antibiotic prophylaxis will be presented with surprising data that does not support routine current clinical practice guidelines. Second, the latest data on serum and synovial biomarkers for the diagnosis of peri-prosthetic joint infection will be provided.  Finally, an in vivo model of antimicrobial implant coating and bioluminescent imaging will provide insight into a unique and novel approach to infection prophylaxis. Overall, this workshop will be highly informative for surgeons and researchers alike who wish to learn about the newest advancements in the prevention and diagnosis of the infected orthopaedic implant. Workshop attendees will have the benefit of a focused session that combines clinical, cellular and molecular updates on this critical area of orthopaedic care.

Antibiotic Prophylaxis in Tumor and Joint Reconstruction: Where Does the Evidence Lead Us?
Michelle Ghert, MD, McMaster University

New Techniques on the Cellular and Molecular Diagnosis of the Infected Joint
Carlos A. Higuera Rueda, Cleveland Clinic Foundation

Novel Molecular Implant Modifications Directed at Infection Prophylaxis
Nicholas Bernthal, MD, University of California Los Angeles

7:30 AM – 9:00 AM

Organizers:
Dominik R. Haudenschild, PhD, University of California, Davis
Blaine A. Christiansen, PhD, University of California, Davis

Joint injuries initiate changes in joint tissue homeostasis that often culminate in osteoarthritis. Currently, many groups focus their research on mechanistically connecting the initial injury event and the eventual osteoarthritis.  The primary purpose of this workshop is to highlight recent advances in the understanding of acute responses to joint injury in different joint tissues.  The three presenters have each approached the identification of early OA from unique perspectives in their research.   This workshop will bring together these unique perspectives. The goal is to establish a more comprehensive understanding of how the interplay between different tissues, matrix gene expression, cytokine and growth factor production, and metabolomics responses during the acute post-injury phase affects the joint.

Injury-induced Changes in Small-molecule Metabolites
Ronald June, PhD, Montana State University

Inflammatory Cytokines and Gene Expression in Acute PTOA
Steven Olson, MD, Duke University Medical Center

Acute Tissue-specific Responses to Joint Injury
Christopher Little, DVM, PhD, Kolling Institute, University of Sydney