ORS Musculoskeletal Biology Workshop at Sun Valley

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ORS Musculoskeletal Biology Workshop at Sun Valley 2017-08-02T17:03:42+00:00

Workshop Agenda

*This is a tentative agenda and is subject to change.

Sunday, August 6

8:00 AM–8:15 AM
Welcome

8:15 AM–9:15 AM
The RIB Award/Plenary Session
Targeting Musculoskeletal Disease to Restore Mobility in Disease and Old Age
Michaela Kneissel, PhD, Novartis

9:30 AM-10:00 AM
Blue Ribbon Sun Valley Posters: Five 3 min summary presentations
Chair: Teresita Bellido, PhD, Indiana University

10:00 AM-10:15 AM
Break

10:15 AM–12:00 PM
Major Methodologies: The Essentials of Finite Element Analysis for Basic and Clinical Studies
Chair: Christopher Jacobs, PhD, Columbia University

Introduction: The Pros and Cons of FEA
Christopher Jacobs, PhD, Columbia University 

Cell Mechanics: The Role of Simulation
Christopher Jacobs, PhD, Columbia University                                   

Finite Element Analysis for Clinical Assessment of Whole-Bone Strength
David Kopperdahl, PhD, O.N. Diagnostics, LLC*

Poster Session with Wine and Cheese

7:30 PM-8:00 PM
Blue Ribbon Sun Valley Posters: Five 3 min summary presentations
Chair: Alexander Robling, PhD, Indiana University

8:00 PM–10:00 PM
Poster viewing

Monday, August 7

8:00 AM–9:00 AM
ASBMR/Harold M. Frost Young Investigator Awards Presentations (3)
Chair: Teresita Bellido, PhD, Indiana University

9:15 AM–12:00 PM
Problems in Endocrinology:  Rare Bone Diseases – Fibrous Dysplasia
Chair: Michael Collins, MD, NIDCR, NIH

Overview of Fibrous Dysplasia. A Complex Mosaic Disease of Activated Gαs
Michael Collins, MD, NIDCR

Clinical Perspectives in Fibrous Dysplasia/McCune-Albright Syndrome
Alison Boyce, MD, NIDCR, NIH

Challenges and Approaches for Fibrous Dysplasia Research
Ed Hsiao, MD, PhD, University of California, San Francisco

1:30 PM – 4:00 PM
Career Development Workshop: Research Funding
Marjolein van der Meulen, PhD, Cornell University, Chair 

Introduction/Overview of Biomedical Research Funding
Marjolein Van der Meulen, PhD, Cornell University

NIH Grants
Gayle Lester, PhD, NIAMS

NSF Grants
David Fyhrie, PhD, National Science Foundation

Panel Discussion:  Grant Writing Advice for Junior Investigators
Moderator: Teresita Bellido, PhD, Indiana University

Discussants:
Susan Bloomfield, PhD, Texas A&M University
Alison Boyce, MD, NIDCR, NIH
Christopher Hernandez, PhD, Cornell University
James Iatridis, PhD, Icahn School of Medicine at Mount Sinai
Hollis Potter, MD, Hospital for Special Surgery

7:30 PM–9:30 PM
New Progress in Imaging Musculoskeletal Tissues
Chair: Felix Wehrli, PhD, University of Pennsylvania

Quantitative MRI of Cortical and Trabecular Bone
Felix Wehrli, PhD, University of Pennsylvania               

Using MRI to Detect Cartilage Damage
Corey Neu, PhD, University of Colorado

In Vivo MRI
Hollis Potter, MD, Hospital for Special Surgery

Tuesday, August 8

7:00 AM-7:30 AM
Industry Breakfast Session presented by Regeneron Pharmaceuticals

Lessons from Rare Genetic Diseases: From Novel Biology to Drug Discovery
Presenter: Aris N. Economides, PhD
Advances in high-throughput DNA sequencing (exome; whole genome) has revolutionized human genomic discovery, providing the opportunity to identify rare causative variants associated with diseases and related traits. Insights gleaned through these discoveries often offer mechanistic insights that can be leveraged as therapeutic targets for diseases of unmet clinical need.  The Regeneron Genetics Center has amassed a portfolio of patient and other populations for this purpose including (i) large patient populations linked to electronic health records (Geisinger Health System DiscovEHR collaboration, UK-Biobank), (ii) focused disease case:control collections for diseases of unmet clinical need, (iii) founder populations which provide opportunities to identify novel drifted disease alleles (Amish, Mennonite, French Canadian, Pima Indian), and (iv) rare families with undiagnosed monogenic diseases. Using this resource, we have made novel discoveries in several disease areas, and for a subset of these diseases we have undertaken the development of therapies.  Examples of each will be discussed.

8:00 AM–9:00 AM
ASBMR/Harold M. Frost Young Investigator Awards Presentations (3)
Chair: Alexander Robling, PhD, Indiana University 

9:15 AM–12:00 PM
Using Genetically Engineered Animal Models to Solve Problems in Musculoskeletal Disease: State of the Art and Application
Chair: Charles O’Brien, PhD, University of Arkansas

Validating Cre Driver Models:  Where are We Cutting and How Do We Know?
Ivo Kalajzic, MD, PhD, University of Connecticut Health Center

How Can We Improve Cre Driver Models?
Charles O’Brien, PhD, University of Arkansas

Modeling Human Disease in Mice
Aris Economides, PhD, Regeneron Pharmaceuticals, NY

4:30 PM – 8:00 PM
Banquet and Symphony

Wednesday, August 9

8:00 AM–9:00 AM
ASBMR/Harold M. Frost Young Investigator Awards Presentations (3)
Chair: David Burr, PhD, Indiana University

9:00 AM-12:00 PM
Problems in Orthopaedics: Degenerative Disk Disease
Chair: James Iatridis, PhD, Icahn School of Medicine at Mount Sinai

Introduction
James Iatridis, PhD, Icahn School of Medicine at Mount Sinai                       

Intervertebral Disc Biology: An Enigma Machine
Makarand Risbud, PhD, Thomas Jefferson University 

Clinical Perspective of Low Back Pain: Still a Black Box
James Kang, MD, Brigham and Women’s Hospital

7:30 PM – 9:30 PM
Next Generation Therapies
Chair: David Burr, PhD, Indiana University

New Approaches to Anabolic Therapy
Ben Leder, MD, Harvard University

Treatment of Osteoarthritis: New Horizons
Nancy Lane, MD, UC Davis

Novel/Potential Therapies for Age-Related Sarcopenia
Roger Fielding, PhD, Tufts University

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