ORS 2013 Annual Meeting Workshop Webcast – Antioxidant Stabilization of Highly Cross-Linked UHMWPE

Antioxidant Stabilization of Highly Cross-Linked UHMWPE
Organizers: Ebru Oral, PhD, Massachusetts General Hospital and Douglas W Van Citters, PhD, Dartmouth College

Patient demands for high-performance, long-lasting total joint implants have driven rapid change and innovation in bearing materials. Highly cross-linked UHMWPEs have decreased wear and osteolysis in the last decade, significantly improving clinical outcomes. However, the increase in the number of arthroplasty operations especially with younger patient populations, and the severely adverse reactions associated with some metal-on-metal joint implants have increased the functional demands on UHMWPE bearings. A recent widespread innovation to develop joint implants with improved function and longevity is the incorporation of antioxidants into cross-linked ultrahigh molecular weight polyethylene (UHMWPE). The purpose of this workshop is to provide all stakeholders with a balanced, state-of-the-art review of the motivations behind using antioxidants, the antioxidant choices available for orthopaedic polymers, the methods by which these might be incorporated into polymers, the biological effects of adding a new agent to the joint space and the clinical outcome data for currently used antioxidant-stabilized implants. The workshop will conclude with future directions with specific focus on how antioxidant stabilized cross-linked UHMWPEs may address unsolved problems in joint arthroplasty. The target audience is orthopaedic researchers, especially those working on the development of bearing surfaces, orthopaedic surgeons looking for more in-depth information on the newest clinical products offered to them and industrial representatives.

The Formulation and Properties of Vitamin E-Stabilized, Highly Cross-Lnked UHMWPEs
Orhun K Muratoglu, PhD, Massachusetts General Hospital
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Antioxidant-Stabilized UHMWPE for Orthopaedics
Venkat Narayan, PhD, DePuy Synthes, a company of Johnson & Johnson
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The Biological Response to Antioxidant UHMWPEs used in Total Joint Replacement 
Joanne Tipper, PhD, University of Leeds
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Antioxidant Stabilized UHMWPEs: Conclusions and Future Directions
Ebru Oral, PhD, Massachusetts General Hospital
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