Journal of Orthopaedic Research

The Journal of Orthopaedic Research (JOR) is the premier source for advanced orthopaedic research in the world today. Fully searchable, the JOR research articles on musculoskeletal subjects range from microbiology to engineering to clinical work, and the archive is searchable all the way back to 1983. Members may also submit research articles of interest to the JOR editors for consideration in future publications.

To review the current journal and archives, to submit an article or to inquire about advertising, visit the search page at Wiley’s Online Library.

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Proceedings of the International Consensus Meeting on Periprosthetic Joint Infection







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Recently Published Articles

Journal of Orthopaedic Research

Wiley Online Library : Journal of Orthopaedic Research

The process of fracture healing is complex, and poor or incomplete healing remains a significant health problem. Proper fracture healing relies upon resident mesenchymal stem cell (MSC) differentiation into chondrocytes and osteoblasts, which are necessary for callus formation and ossification. A…
Author: Philip M. Roper, Pegah Abbasnia, Aleksandra Vuchkovska, Roman M. Natoli, John J. Callaci
Posted: July 29, 2016, 4:45 pm
Anterior cruciate ligament (ACL) injury is a known risk factor for future development of osteoarthritis (OA). This human clinical study seeks to determine if early changes to cartilage MRI T2 maps between baseline and 6 months following ACL reconstruction (ACLR) are associated with changes to car…
Author: Ashley Williams, Carl S. Winalski, Constance R. Chu
Posted: July 29, 2016, 5:20 am
Distraction osteogenesis (DO) technique could be used to manage large-size bone defect successfully, but DO process usually requires long duration of bone consolidation. Innovative approaches for augmenting bone consolidation are of great need. Staphylococcal enterotoxin C2 (SEC2) has been found …
Author: Jia Xu, Tianyi Wu, Yuxin Sun, Bin Wang, Jinfang Zhang, Wayne Yuk-Wai Lee, Yimin Chai, Gang Li
Posted: July 29, 2016, 5:15 am
Post-traumatic joint contracture is a frequent orthopaedic complication that limits the movement of injured joints, thereby severely impairing affected patients. Non-surgical and surgical treatments for joint contracture often fail to improve the range of motion. In this study, we tested a hypoth…
Author: Andrzej Steplewski, Jolanta Fertala, Pedro K. Beredjiklian, Joseph A. Abboud, Mark L.Y. Wang, Surena Namdari, Jonathan Barlow, Michael Rivlin, William V. Arnold, James Kostas, Cheryl Hou, Andrzej Fertala
Posted: July 29, 2016, 5:01 am
Qualitative studies have shown that the periprosthetic cortical bone may decrease in the first years after the implantation of an osseointegrated leg prosthesis (OILP) in patients with a transfemoral amputation. The resorption of periprosthetic cortical bone may endanger implant survival because …
Author: Lisanne Maria Haket, Johannes Paulus Maria Frölke, Nico Verdonschot, Pawel Krzysztof Tomaszewski, Henk van de Meent
Posted: July 28, 2016, 7:00 pm
The mechanical loading environment influences the development and maturation of joints. In this study, the influence of imbalanced muscular loading on joint development was studied using localized chemical denervation of hip stabilizing muscle groups in neonatal mice. It was hypothesized that imb…
Author: Caleb A. Ford, Niamh C. Nowlan, Stavros Thomopoulos, Megan L. Killian
Posted: July 25, 2016, 5:01 am
Innate immune reactions to orthopedic implant debris are the primary cause of total joint replacement (TJR) failure over the long term (15–20 years). The role of pathogen associated pattern recognition receptors (i.e., TLRs) in regulating immune reactivity to metal implant particles remains contr…
Author: Lauryn Samelko, Stefan Landgraeber, Kyron McAllister, Joshua Jacobs, Nadim J. Hallab
Posted: July 25, 2016, 4:51 am
The nuclear retinoic acid receptors (RARs) play key roles in skeletal development and endochondral ossification. Previously, we showed that RARγ regulates chondrogenesis and that pharmacological activation of RARγ blocked heterotopic ossification (HO), pathology in which endochondral bone forms i…
Author: Kenta Uchibe, Jiyeon Son, Colleen Larmour, Maurizio Pacifici, Motomi Enomoto-Iwamoto, Masahiro Iwamoto
Posted: July 23, 2016, 4:35 am
The objective of this study was to quantify and compare the contrast-enhancing properties of the anionic contrast agent ioxaglate/Hexabrix, and cationic contrast agent CA4+ for biochemical and morphological characterization of the intervertebral disc (IVD) via μCT. Optimal contrast agent concentr…
Author: Michael D. Newton, Samantha E. Hartner, Shannon Timmons, Nathan D. Delaney, Michael G. Pirrone, Kevin C. Baker, Tristan Maerz
Posted: July 23, 2016, 4:35 am
This study addresses the hypothesis that adjacent segment intervertebral joint loads are sensitive to the degree of lordosis that is surgically imposed during vertebral fusion. Adjacent segment degeneration is often observed after lumbar fusion, but a causative mechanism is not yet clearly eviden…
Author: Marco Senteler, Bernhard Weisse, Dominique A. Rothenfluh, Mazda T. Farshad, Jess G. Snedeker
Posted: July 23, 2016, 4:30 am
Certain types of joint injuries, common in athletes, are known to have a high association with the development of osteoarthritis (OA). Post-traumatic osteoarthritis (PTOA) is especially debilitating due to its earlier onset than traditional OA, and its predisposition to affect a younger and more …
Author: Andrew Carbone, Scott Rodeo
Posted: July 23, 2016, 4:25 am
This study investigated sex differences in knee biomechanics and investigated determinants for difference in a geriatric population. Age-matched healthy volunteers (42 male and 42 female, average age 65 years) without knee OA were included in the study. Subjects underwent physical examination on …
Author: Du Hyun Ro, Dong Yeon Lee, Giho Moon, Sahnghoon Lee, Sang Gyo Seo, Seong Hwan Kim, In Woong Park, Myung Chul Lee
Posted: July 21, 2016, 4:30 pm
Trabecular bone and cortical bone have different bone remodeling levels, and the underlying mechanisms are not fully understood. In the present study, the expression of Wnt/β-catenin signaling and its downstream molecules along with bone mass in trabecular and cortical bone were compared in wild-…
Author: Junfeng Li, Quanwei Bao, Sixu Chen, Huayu Liu, Jianquan Feng, Hao Qin, Ang Li, Daocheng Liu, Yue Shen, Yufeng Zhao, Zhaowen Zong
Posted: July 21, 2016, 3:55 am
Intervertebral disc degeneration is characterized by an imbalance between catabolic and anabolic signaling, with an increase in catabolic cytokines particularly IL-1β, a key regulator of IVD degeneration. This study aimed to investigate intracellular signaling pathways activated by IL-1β, and GDF…
Author: Jodie Daniels, Abbie A. L. Binch, Christine L. Le Maitre
Posted: July 21, 2016, 3:55 am
The time-course of cancellous bone regeneration surrounding mechanically loaded implants affects implant fixation, and is relevant to determining optimal rehabilitation protocols following orthopaedic surgeries. We investigated the influence of controlled mechanical loading of titanium-coated pol…
Author: Shailly H. Jariwala, Hwabok Wee, Evan P. Roush, Tiffany L. Whitcomb, Christopher Murter, Gery Kozlansky, Akhlesh Lakhtakia, Allen R. Kunselman, Henry J. Donahue, April D. Armstrong, Gregory S. Lewis
Posted: July 21, 2016, 3:50 am