Journal of Orthopaedic Research

Call for Papers for a Special Theme Issue of the Journal of Orthopaedic Research:  New Frontiers in Tendon Research

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The Journal of Orthopaedic Research (JOR) is the premier source for advanced orthopaedic research in the world today. Fully searchable, the JOR research articles on musculoskeletal subjects range from microbiology to engineering to clinical work, and the archive is searchable all the way back to 1983. Members may also submit research articles of interest to the JOR editors for consideration in future publications.

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Recently Published Articles

Journal of Orthopaedic Research

Wiley Online Library : Journal of Orthopaedic Research

Imbalanced metabolism of Nucleus pulposus (NP) extracellular matrix (ECM) is closely correlated to Intervertebral Disc Degenerative Disease. LIM mineralization protein-1 (LMP-1) has been proven to induce sulfated glycosaminoglycan (sGAG) production in NP and have an anti-inflammatory effect in pr…
Author: Hui Liu, Hehai Pan, Hao Yang, Jianru Wang, Kuibo Zhang, Xiang Li, Hua Wang, Wenbin Ding, Bingxue Li, Zhaomin Zheng
Posted: October 21, 2014, 11:53 pm
Bone Morphogenetic Protein 2 (BMP2) regulates bone integrity by driving both osteogenesis and osteoclastogenesis. However, BMP2 as a therapeutic has significant drawbacks. We have designed a novel peptide CK2.3 that blocks the interaction of Casein Kinase 2 (CK2) with Bone Morphogenetic Protein R…
Author: Hemanth Akkiraju, Jeremy Bonor, Kristine Olli, Chris Bowen, Beth Bragdon, Harold Coombs, Leah Rae Donahue, Randall Duncan, Anja Nohe
Posted: October 20, 2014, 5:20 pm
Modular hip implants allows for the adjustment of leg length, offset, and the ability to remove the head for acetabular exposure during primary and revision surgery. The design of the Morse taper facilitates the intimate contact of the conical trunnion of the femoral stem (male component), with t…
Author: Selin Munir, William L. Walter, William Robert Walsh
Posted: October 15, 2014, 10:35 pm
Mohawk homeobox (MKX) has been demonstrated as a tendon/ligament specific transcription factor. The aim of this study was to investigate the role of MKX in ligament/tenogenic differentiation of bone marrow derived mesenchymal stem cells (BMMSCs). Human BMMSCs were treated with 50 ng/ml BMP-12 or …
Author: Koji Otabe, Hiroyuki Nakahara, Akihiko Hasegawa, Tetsuya Matsukawa, Fumiaki Ayabe, Naoko Onizuka, Masafumi Inui, Shuji Takada, Yoshiaki Ito, Ichiro Sekiya, Takeshi Muneta, Martin Lotz, Hiroshi Asahara
Posted: October 13, 2014, 5:48 pm
Severe pincer impingement (acetabular protrusio) is an established cause of hip pain and osteoarthritis. The proposed underlying pathomechanism is a dynamic pathological contact of the prominent acetabular rim with the femoral head-neck junction. However, this cannot explain the classically descr…
Author: Emanuel F. Liechti, Stephen J. Ferguson, Moritz Tannast
Posted: October 8, 2014, 4:13 pm
To compare the excursion efficiency and moment arms of flexor digitorum superficialis (FDS) and profundus (FDP) among different conditions of pulley integrity related to trigger finger treatment, cadaveric fingers were first tested with an intact pulley system, and then the first (A1) and second …
Author: Szu-Ching Lu, Tai-Hua Yang, Li-Chieh Kuo, I-Ming Jou, Yung-Nien Sun, Fong-Chin Su
Posted: October 8, 2014, 3:55 pm
Mast cells and fibroblasts are two key players involved in many fibrotic and degenerative disorders. In the present study we examined the nature of binding interactions between human mast cells and tendon fibroblasts (tenocytes). In the mast cell-fibroblast co-culture model, mast cells were shown…
Author: Hayedeh Behzad, Shu-Huei Tsai, Paulina Nassab, Rouhollah Mousavizadeh, Robert G. McCormack, Alex Scott
Posted: October 7, 2014, 1:56 pm
Coxa antetorta describes an abnormal torsion of the femur. It is commonly considered a cosmetic problem and is treated surgically only in severe cases and the presence of physical complaints. The purpose of this study was to identify deviations in gait kinematics and kinetics in pediatric patient…
Author: Marina Bruderer-Hofstetter, Verena Fenner, Erika Payne, Katja Zdenek, Harry Klima, Regina Wegener
Posted: October 4, 2014, 7:11 pm
Joint injuries and subsequent osteoarthritis (OA) are the leading causes of chronic joint disease. In this work, we explore the possibility of applying magnetic resonance spectroscopy-based metabolomics to detect host responses to an anterior cruciate ligament (ACL) reconstruction injury in synov…
Author: Beata Mickiewicz, Bryan J. Heard, Johnny K. Chau, May Chung, David A. Hart, Nigel G. Shrive, Cyril B. Frank, Hans J. Vogel
Posted: October 4, 2014, 7:10 pm
Magnetic resonance imaging (MRI) with T2-weighting is routinely performed to assess intervertebral disc degeneration. Standard clinical evaluations of MR images are qualitative, however, and do not focus on region-specific alterations in the disc. Utilizing a rabbit needle puncture model, T2 mapp…
Author: John T. Martin, Christopher M. Collins, Kensuke Ikuta, Robert L. Mauck, Dawn M. Elliott, Yeija Zhang, D. Greg Anderson, Alexander R. Vaccaro, Todd J. Albert, Vincent Arlet, Harvey E. Smith
Posted: October 1, 2014, 3:23 pm
Parathyroid hormone (PTH) 1–34 is known to enhance fracture healing. Tendon repair is analogous to bone healing in its dependence on the proliferation and differentiation of mesenchymal stem cells, matrix formation, and tissue remodeling.1,2,3 We hypothesized that PTH 1–34 enhances tendon healing…
Author: Daniel J. Lee, Richard D. Southgate, Youssef M. Farhat, Alayna E. Loiselle, Warren C. Hammert, Hani A. Awad, Regis J. O’Keefe
Posted: September 29, 2014, 2:16 pm
Cartilage-derived mesenchymal stem cells (MSCs) have been isolated with different methods. In this study lateral and medial femoral condyles were respectively collected from patients with late-stage osteoarthritis during the total knee arthroplasty. After digestion of the cartilage tissues with t…
Author: Xinlin Su, Wei Zuo, Zhihong Wu, Jun Chen, Nan Wu, Pei Ma, Zenan Xia, Chao Jiang, Zixing Ye, Sen Liu, Jiaqi Liu, Guangqian Zhou, Chao Wan, Guixing Qiu
Posted: September 29, 2014, 2:09 pm
Kashin–Beck disease (KBD) is a chronic, deforming endemic osteoarticular disease with altered metabolism of the cartilage matrix. Matrix metalloproteinases (MMPs), aggrecanases (ATAMTSs), and their inhibitors (TIMPs) play important roles in cartilage formation and matrix degradation. This study i…
Author: Jinghong Chen, Mingxiu Luo, Wei Wang, Zentie Zhang, Ying He, Victor C. Duance, Clare E. Hughes, Bruce Caterson, Junling Cao
Posted: September 26, 2014, 2:40 pm
Footwear-generated biomechanical manipulation of lower-limb joints has been shown to influence lower-limb biomechanics. Numerous studies report the influence of such interventions on the knee, however little is known about the influence of these interventions on the hip. The present study analyze…
Author: Deborah Solomonow-Avnon, Alon Wolf, Amir Herman, Nimrod Rozen, Amir Haim
Posted: September 25, 2014, 2:15 pm
Cobalt and chromium species are released in the local tissues as a result of tribo-corrosion, and affect bone cell survival and function. However we have little understanding of the mechanisms of cellular entry, intracellular distribution, and speciation of the metals that result in impaired bone…
Author: Karan M. Shah, Paul D. Quinn, Alison Gartland, J. Mark Wilkinson
Posted: September 23, 2014, 7:28 am