Journal of Orthopaedic Research

The Journal of Orthopaedic Research (JOR) is the premier source for advanced orthopaedic research in the world today. Fully searchable, the JOR research articles on musculoskeletal subjects range from microbiology to engineering to clinical work, and the archive is searchable all the way back to 1983. Members may also submit research articles of interest to the JOR editors for consideration in future publications.

To review the current journal and archives, to submit an article or to inquire about advertising, visit the search page at Wiley’s Online Library.

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Recently Published Articles

Journal of Orthopaedic Research

Wiley Online Library : Journal of Orthopaedic Research

The pathological mechanism of intractable low back pain is unclear. However, intervertebral disc (IVD) degeneration is a primary cause of low back pain, and pain-related mediators, such as interleukin-6 (IL-6), have been correlated with discogenic pain. The objective of this study is to elucidate…
Author: Takeshi Sainoh, Sumihisa Orita, Masayuki Miyagi, Yoshihiro Sakuma, Kazuyo Yamauchi, Miyako Suzuki, Go Kubota, Yasuhiro Oikawa, Kazuhide Inage, Jun Sato, Kazuki Fujimoto, Yasuhiro Shiga, Gen Inoue, Yasuchika Aoki, Kazuhisa Takahashi, Seiji Ohtori
Posted: May 23, 2015, 10:49 pm
Critical appraisal of the literature highlights that the discriminative power of gait-related features in patients with hip osteoarthritis (OA) has not been fully explored. We aimed to reduce the number of gait-related features and define the most discriminative ones comparing the three-dimension…
Author: Christophe A.G. Meyer, Kristoff Corten, Steffen Fieuws, Kevin Deschamps, Davide Monari, Mariska Wesseling, Jean-Pierre Simon, Kaat Desloovere
Posted: May 21, 2015, 8:58 pm
We hypothesized that systemic ceftriaxone and high concentration local antibiotics might eradicate peri-implant sepsis. Experiment 1: Eighty-four implants inoculated with biofilm-forming Staphylococcus aureus were treated in vitro with gentamicin, vancomycin, gentamicin + rifampin, or vancomycin …
Author: Anna S. van der Horst, Suman Medda, Ethan Ledbetter, Alexander Liu, Paul Weinhold, Daniel J. Del Gaizo, Laurence Dahners
Posted: May 21, 2015, 8:58 pm
Osteogenesis of mesenchymal stem cells (MSCs) is essential for bone repair. Recently, microRNAs have been proven to play an important role in the regulation of MSC differentiation, including osteogenesis. Here, the function of microRNA-21 (miR-21) in the osteogenic differentiation of human umbili…
Author: Yu-Bin Meng, Xue Li, Zhao-Yang Li, Jin Zhao, Xu-Bo Yuan, Yu Ren, Zhen-Duo Cui, Yun-De Liu, Xian-Jin Yang
Posted: May 21, 2015, 8:57 pm
There are no published studies describing the strength quadrupled gracilis tendon alone and quadrupled semitendinosus tendon alone in the configuration used for anterior cruciate ligament (ACL) reconstruction. The primary objective was to compare the mechanical properties of grafts used for ACL r…
Author: Régis Pailhé, Etienne Cavaignac, Jérôme Murgier, Jean-Michel Laffosse, Pascal Swider
Posted: May 21, 2015, 8:57 pm
Predicting fracture risk for patients with metastatic femoral lesions remains an important clinical problem. Mirels’ criterion remains the most formalized radiographic scoring system with good sensitivity (correctly identifying clinical fractures) but relatively poor specificity (correctly identi…
Author: Jacklyn R. Goodheart, Richard J. Cleary, Timothy A. Damron, Kenneth A. Mann
Posted: May 21, 2015, 8:57 pm
In this study, we explore topographical changes in proteoglycan distribution from femoral condylar cartilage in early osteoarthritis, acquired from both the lateral and medial condyles of anterior cruciate ligament transected (ACLT) and contralateral (CNTRL) rabbit knee joints, at 4 weeks post op…
Author: Mikko E.A. Arokoski, Virpi Tiitu, Jukka S. Jurvelin, Rami K. Korhonen, James M. Fick
Posted: May 21, 2015, 8:56 pm
Axial dynamization of an osteosynthesis construct can promote fracture healing. This biomechanical study evaluated a novel dynamic locking plate that derives symmetric axial dynamization by elastic suspension of locking holes within the plate.
Standard locked and dynamic plating constructs were t…
Author: Stanley Tsai, Daniel C. Fitzpatrick, Steven M. Madey, Michael Bottlang
Posted: May 21, 2015, 8:56 pm
Periodontal ligament (PDL) fibroblasts play an important role in preserving periodontal homeostasis and transmitting mechanical signals to alveolar bone. Connexin 43 (Cx43), a gap junction protein, is essential for bone homeostasis and regulates bone remodeling. However, the function of Cx43 in h…
Author: Shengnan Li, Huajing Zhang, Shuna Li, Yanqi Yang, Bo Huo, Ding Zhang
Posted: May 21, 2015, 8:56 pm
The most important factor contributing to short-term and long-term success of cementless total joint arthroplasties is osseointegration. Osseointegration leads to a direct structural and functional connection between living bone and the surface of an implant. Surface contaminants may remain on or…
Author: Lindsay A. Bonsignore, Victor M. Goldberg, Edward M. Greenfield
Posted: May 21, 2015, 8:56 pm
Augmented microfracture techniques use growth factors, cells, and/or scaffolds to enhance the healing of microfracture-treated cartilage defects. This study investigates the effect of delivering recombinant human fibroblastic growth factor 18 (rhFHF18, Sprifermin) via a collagen membrane on the h…
Author: Daniel Howard, John Wardale, Hans Guehring, Frances Henson
Posted: May 21, 2015, 8:55 pm
Altered knee kinematics following ACL reconstruction may predispose patients to the development of early onset post-traumatic osteoarthritis. The goal of our study was to examine the longitudinal interrelationship between altered tibial position relative to the femur and cartilage health measured…
Author: Musa Zaid, Drew Lansdown, Favian Su, Valentina Pedoia, Lauren Tufts, Sarah Rizzo, Richard B. Souza, Xiaojuan Li, C. Benjamin Ma
Posted: May 21, 2015, 8:55 pm
We investigated whether nasal chondrocytes (NC) can be used to generate composite constructs with properties necessary for the repair of osteochondral (OC) lesions, namely maturation, integration and capacity to recover from inflammatory burst. OC grafts were fabricated by combining engineered ca…
Author: Marina Barandun, Lukas Daniel Iselin, Francesco Santini, Michele Pansini, Celeste Scotti, Daniel Baumhoer, Oliver Bieri, Ueli Studler, Dieter Wirz, Martin Haug, Marcel Jakob, Dirk Johannes Schaefer, Ivan Martin, Andrea Barbero
Posted: May 20, 2015, 11:21 pm
The purpose of this study was to compare knee extension torque variability in patients with ACL reconstructed knees before and after exercise. Thirty two patients with an ACL reconstructed knee (ACL-R group) and 32 healthy controls (control group) completed measures of maximal isometric knee exte…
Author: John Goetschius, Christopher M. Kuenze, Joseph M. Hart
Posted: May 20, 2015, 11:21 pm
Available evidence indicates that some Tie2-expressing (Tie2+) cells serve as multipotent progenitors that have robust BMP-dependent osteogenic activity and mediate heterotopic ossification (HO). Since signaling through the G protein Gi is required for cell motility, we hypothesized that blockade…
Author: Liping Wang, Dylan O’ Carroll, Xuhui Liu, Theresa Roth, Hubert Kim, Bernard Halloran, Robert A. Nissenson
Posted: May 20, 2015, 2:29 pm