The Journal of Orthopaedic Research (JOR) is the premier source for advanced orthopaedic research in the world today. Fully searchable, the JOR research articles on musculoskeletal subjects range from microbiology to engineering to clinical work, and the archive is searchable all the way back to 1983. Members may also submit research articles of interest to the JOR editors for consideration in future publications.
To review the current journal and archives, to submit an article or to inquire about advertising, visit the search page at Wiley’s Online Library.
Although integrin-linked kinase (ILK) has been suggested to play a role in the tumorigenesis of a number of human epithelial carcinomas, little is known of its role in musculoskeletal sarcoma. The authors studied ILK expression by immunohistochemistry using osteosarcoma prechemotherapy specimens …
Author: Seung Hwan Rhee, Ilkyu Han, Mi Ra Lee, Hwan Seong Cho, Joo Han Oh, Han-Soo Kim
Posted: June 19, 2013, 2:10 pm
This study investigated the internal fluid pressure of human cadaver meniscal root attachments. A pressure micro-sensor was implanted inside each attachment site. Tibiofemoral joints were compressed to 2× body weight at various flexion angles and pressure recorded for 20 min. The anterior cruciat…
Author: Adam C. Abraham, Diego F. Villegas, Kenton R. Kaufman, Tammy L. Haut Donahue
Posted: June 17, 2013, 2:28 pm
It is often difficult to decouple the relative importance of different factors in regulating MSC differentiation. Genetically modified mice provide model systems whereby some variables can be manipulated while others are kept constant. Fracture repair in thrombospondin-2 (TSP2)-null mice is chara…
Author: Darren Burke, Michael Dishowitz, Mariya Sweetwyne, Emily Miedel, Kurt D. Hankenson, Daniel J. Kelly
Posted: June 15, 2013, 5:16 pm
microRNAs are small non-coding RNAs that in the last decade have emerged as overarching regulators of gene expression. Their abundance, ability to repress a large number of target genes and overlapping target specificity indicate a complex network of interactions that is still being defined. A nu…
Author: Gary Gibson, Hiroshi Asahara
Posted: June 10, 2013, 1:42 pm
We compared the mechanical force of tendon-to-bone repair techniques for flexor tendon reconstruction. Thirty-six flexor digitorum profundus (FDP) tendons were divided into three groups based upon the repair technique: (1) suture/button repair using FDP tendon (Pullout button group), (2) suture b…
Author: Zhuang Wei, Andrew R. Thoreson, Peter C. Amadio, Kai-Nan An, Chunfeng Zhao
Posted: June 10, 2013, 1:28 pm
Heterotopic mineralization may result in tendon weakness, but effects on other biomechanical responses have not been reported. We used a needle injury, which accelerates spontaneous mineralization of murine Achilles tendons, to test two hypotheses: that injured tendons would demonstrate altered b…
Author: Etienne John Ogilvy O’Brien, Nigel G. Shrive, Joshua M. Rosvold, Gail M. Thornton, Cyril B. Frank, David A. Hart
Posted: June 10, 2013, 1:27 pm
A recently developed murine model of tendinopathy, induced by TGF-β1 injection, has been used to examine the reparative capacity of tendinopathic Achilles in Adamts5−/− mice. After TGF-β1 injection and 2 weeks of treadmill exercise, the Achilles from Adamts5−/− mice exhibited a reduction in maxim…
Author: Rebecca Bell, Jun Li, Elizabeth F. Shewman, Jorge O. Galante, Brian J. Cole, Bernard R. Bach, Karen L. Troy, Katalin Mikecz, John D. Sandy, Anna H. Plaas, Vincent M. Wang
Posted: June 10, 2013, 1:18 pm
Bone is typically well suited for its habitual loading environment because of its ability to adapt. Although characteristics of the mechanical loading environment predict the bone adaptive response in animals, this has not been prospectively validated in humans. Here, we describe an in vivo loadi…
Author: Karen L. Troy, William Brent Edwards, Varun A. Bhatia, Mary Lou Bareither
Posted: June 6, 2013, 8:25 am
Micro-finite element (μFE) modeling has shown promise in evaluating the structural integrity of trabecular bone. Histologic microcrack analyses have been compared to μFE models of trabecular bone cores to demonstrate the potential of this technique. To date this has not been achieved in whole bon…
Author: Ryan Herblum, Maarten Beek, Cari M Whyne
Posted: June 4, 2013, 2:20 pm
There is a need to understand how obesity and aging interact to cause an increased risk of medial knee osteoarthritis (OA). This study tested whether the knee adduction and flexion moments increase with age in healthy normal-weight and obese adults, as well as the mechanism of this increase. We a…
Author: Katerina Blazek, Jessica L. Asay, Jennifer Erhart-Hledik, Thomas Andriacchi
Posted: June 4, 2013, 2:18 pm
The failure of orthopedic implants in osteoporotic patients is attributed to the lack of sufficient bone stock and regenerative capacity but most treatments for osteoporosis fail to address this issue. rhBMP-2 is known to promote bone formation under normal conditions but has not been used clinic…
Author: Mohammad Reza Zarrinkalam, Christopher G Schultz, David W Ardern, Barrie Vernon-Roberts, Robert J Moore
Posted: June 4, 2013, 2:18 pm
© 2013 Orthopaedic Research Society Published by Wiley Periodicals, Inc. J Orthop Res XX:XXX–XXX, 2013
Author: Aspenberg Per
Posted: June 4, 2013, 1:53 pm
The extracellular matrix (ECM) of the human intervertebral disc is rich in molecules that interact with cells through integrin-mediated attachments. Porcine nucleus pulposus (NP) cells have been shown to interact with laminin (LM) isoforms LM-111 and LM-511 through select integrins that regulate …
Author: D. T. Bridgen, C. L. Gilchrist, W. J. Richardson, R. E. Isaacs, C. R. Brown, K. L. Yang, J. Chen, L. A. Setton
Posted: June 4, 2013, 1:53 pm
Neuropeptide Y acting via it’s Y1 receptor represents a powerful pathway in the control of bone mass. The global or osteoblast-specific Y1 receptor deletion induces pronounced bone anabolic effects in mice. However, the contribution of Y1 receptor deletion in bone repair/healing remained to be cl…
Author: Daniela M. Sousa, Michelle M. McDonald, Kathy Mikulec, Lauren Peacock, Herbert Herzog, Meriem Lamghari, David G. Little, Paul A. Baldock
Posted: June 3, 2013, 9:38 pm
Non-inflammatory fibrosis and thickening of the subsynovial connective tissue (SSCT) are characteristic in carpal tunnel syndrome (CTS) patients. These pathological changes have been linked to repetitive hand tasks that create shear forces between the flexor tendons and SSCT. We measured the rela…
Author: Jimmy Tat, Aaron M. Kociolek, Peter J. Keir
Posted: June 1, 2013, 4:33 pm
