Journal of Orthopaedic Research

The Journal of Orthopaedic Research (JOR) is the premier source for advanced orthopaedic research in the world today. Fully searchable, the JOR research articles on musculoskeletal subjects range from microbiology to engineering to clinical work, and the archive is searchable all the way back to 1983. Members may also submit research articles of interest to the JOR editors for consideration in future publications.

To review the current journal and archives, to submit an article or to inquire about advertising, visit the search page at Wiley’s Online Library.

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Proceedings of the International Consensus Meeting on Periprosthetic Joint Infection







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Recently Published Articles

Journal of Orthopaedic Research

Wiley Online Library : Journal of Orthopaedic Research

The molecular mechanisms of intervertebral disc degeneration (IDD) remain elusive. We found that miR-155 is down-regulated in degenerative nucleus pulposus (NP), and more severe degeneration is correlated with higher matrix metallopeptidase 16 (MMP-16) expression. MMP-16 also degraded matrix aggr…
Author: Wei-Lin Zhang, Yu-Fei Chen, Hong-Zheng Meng, Jun-Jie Du, Guan-Nan Luan, Hai-Qiang Wang, Mao-Wei Yang, Zhuo-Jing Luo
Posted: May 26, 2016, 5:25 pm
Despite increasing evidence that subchondral bone contributes to OA pathogenesis, little is known about local changes in bone structure compared to cartilage degeneration. This study linked structural adaptation of subchondral bone with histological osteoarthritis grade. Twenty five osteochondral…
Author: Mikko A.J. Finnilä, Jerome Thevenot, Olli-Matti Aho, Virpi Tiitu, Jari Rautiainen, Sami Kauppinen, Miika T. Nieminen, Kenneth Pritzker, Maarit Valkealahti, Petri Lehenkari, Simo Saarakkala
Posted: May 26, 2016, 5:25 pm
Lower back pain is one of the main contributors to morbidity and chronic disability in the United States. Despite the significance of the problem, it is still not well understood. There is a clear need for objective, non-invasive biomarkers to localize specific pain generators and identify early …
Author: Prachi Pandit, Jason F. Talbott, Valentina Pedoia, William Dillon, Sharmila Majumdar
Posted: May 26, 2016, 5:20 pm
Total intervertebral disc replacement with a biologic engineered disc may be an alternative to spinal fusion for treating end-stage disc disease. In previous work, we developed disc-like angle ply structures (DAPS) that replicate the structure and function of the native disc and a rat tail model …
Author: John T. Martin, Dong Hwa Kim, Andrew H. Milby, Christian G. Pfeifer, Lachlan J. Smith, Dawn M. Elliott, Harvey E. Smith, Robert L. Mauck
Posted: May 26, 2016, 5:15 pm
Posted: May 26, 2016, 4:59 pm
Posted: May 26, 2016, 4:59 pm
Delay in diagnosing osteoarticular tuberculosis (OATB) contributes significantly to morbidity by causing disfiguration and neurological sequelae. The delay caused by conventional culture and the expertise and expense involved in other nucleic acid based tests, make LAMP (loop-mediated isothermal …
Author: Kusum Sharma, Megha Sharma, Nitya Batra, Aman Sharma, Mandeep Singh Dhillon
Posted: May 25, 2016, 4:30 am
The relationship between neurotrophins produced by human annulus cells, such as neurotrophin-4 (NT4) and brain-derived neurotrophic factor (BDNF) which function in neurite survival and outgrowth, and nerve ingrowth into the disc remains poorly understood. In this work, we tested F11 neurite growt…
Author: Helen E. Gruber, Gretchen L. Hoelscher, Letitia Bullock, Jane A. Ingram, H. James Norton, Edward N. Hanley
Posted: May 25, 2016, 4:00 am
Common post-operative problems in shoulder arthroplasty such as glenoid loosening and joint instability may be reduced by improvements in glenoid design, shape, material choice and fixation method. A framework for parametric analysis of different implant fixation configurations was developed in o…
Author: Diogo M. Geraldes, Ulrich Hansen, Andrew A. Amis
Posted: May 24, 2016, 11:15 am
The landscape of basic science in the United States and around the world is changing, and the field of orthopaedic research is positioned to lead by embracing a culture of collaborative, team science that reflects our field’s interdisciplinary nature. In this article we hope to address some of th…
Author: Chelsea S Bahney, Scott Bruder, Jarrett D Cain, Joyce Keyak, Megan Killian, Irving Shapiro, Lynne C. Jones
Posted: May 24, 2016, 11:15 am
Kinematic alignment is a method of aligning implants in total knee arthroplasty (TKA) that strives to restore the native flexion-extension (F-E) and longitudinal rotation (LR) axes of the tibiofemoral joint. The anterior cruciate ligament (ACL) is typically resected at the time of TKA, which migh…
Author: Daniel P Bonny, S. M. Howell, M L Hull
Posted: May 24, 2016, 11:10 am
The pathomechanism of the ligamentumflavum (LF) hypertrophy in diabetic patients with lumbar spinal canal stenosis (LSCS) remains unclear.A cross-sectional study was undertaken to investigate the mechanism of LF hypertrophy in thesepatients. Twenty-four diabetic and 20normoglycemic patients with …
Author: Jiaquan Luo, Lu Huang, Zhuo Chen, Zhaoxun Zeng, Takeshi Miyamoto, Hao Wu, Zhongzu Zhang, Zhimin Pan, Nobuyuki Fujita, Tomohiro Hikata, Akio Iwanami, Takashi Tsuji, Ken Ishii, Masaya Nakamura, Morio Matsumoto, Kota Watanabe, Kai Cao
Posted: May 21, 2016, 9:05 pm
This study investigated the pathological process of Notch signaling in the osteogenesis of ligamentum flavum tissues and cells, and the associated regulatory mechanisms. Notch receptors, ligands, and target genes were identified by quantitative polymerase chain reaction (qPCR) in ligamentum flavu…
Author: Xiaochen Qu, Zhongqiang Chen, Dongwei Fan, Chuiguo Sun, Yan Zeng, Xiaofei Hou, Shanglong Ning
Posted: May 21, 2016, 9:05 pm
Scoliosis deformity has been linked with deleterious changes in the thoracic cavity that affect pulmonary function. The causal relationship between spinal deformity and pulmonary function has yet to be fully defined. It has been hypothesized that deformity correction improves pulmonary function b…
Author: Charles G.T. Ledonio, Benjamin E. Rosenstein, David W. Polly, Charles E. Johnston, Warren E. Regelmann, David J. Nuckley
Posted: May 21, 2016, 9:05 pm
Contaminated suture material plays an important role in the physiopathology of surgical site infections. Recently, suture material has been developed characterized by barbs projecting from a monofilament base. Claimed advantages for barbed sutures are a shortened wound closure time and reduced ma…
Author: Jonas Dhom, Dominik A. Bloes, Andreas Peschel, Ulf Krister Hofmann
Posted: May 21, 2016, 9:05 pm