Workshops / Symposia
| SATURDAY, FEBRUARY 10 |
8:30 AM – 5:30 PM |
Room: Marina Ballroom D (Level 3)
ORS/OREF Grant Writing Workshop
The ORS Mentoring Committee is pleased to present the third annual Grant Writing Workshop at the ORS Annual Meeting in San Diego. The course is designed for new investigators in the process of writing their first grant proposals, and will include a mock study section so that investigators can see what is involved in NIH peer review. Attendees are encouraged to submit a grant to the ORS office. Two grants, one initial and one revised grant, will be chosen for review during the mock study section. The faculty have all been members of the NIH study section, and have participated in the ORS/OREF/AAOS sponsored Grant Writing Workshop held annually each spring.
The workshop will include introductory talks from NIAMS representatives, and discussions of each of the components of a R01 proposal from both a basic science and clinical research viewpoint. A mock study section will take place during lunch with faculty providing reviews. This will be followed by discussions of interpreting pink sheets, and what to do when you get your first grant.
($75 per person, includes continental breakfast, boxed lunch and syllabus.)
Registration is on a first-come, first-served basis. Registration is limited to 50 participants. Grant Writing Workshop Syllabus will be distributed to workshop attendees on-site.
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NEW for 2007 – Workshops 1-8 Handouts ORS will have a limited number of stations to print handouts on-site. To avoid lines, we encourage you to make your selections in advance before arriving in San Diego. |
| SUNDAY, FEBRUARY 11 7:00 AM - 8:30 AM |
Workshop 1 Room 6B Download Handout 
Live Cell and Tissue Imaging: Applications in Orthopedics
Organizers: Anna Plaas, PhD, Tampa, FL and Barbara M. Vertel, PhD, North Chicago, IL
The biomedical sciences have been transformed by advances in microscopy that now allow dynamic investigations in living cells and tissues. Significant progress has been made through the introduction of fluorescent tags, confocal and two-photon optics, image deconvolution and green fluorescent protein expression systems. The new, high-resolution optical imaging methodologies have a broad range of applications in musculoskeletal medicine, including the minimally invasive diagnosis of tissue defects and disease progression. Our understanding of cell dynamics has been greatly improved, as exemplified by the visualization of biosynthesis and trafficking within individual cells, cell-matrix interactions during migration, proliferation and phagocytosis in inflammation and wound healing, and quantification of tissue structure and biochemistry in bioengineering.
Visualizing Matrix Production in Single Chondrocytes
Speaker: Barbara M. Vertel, PhD, North Chicago, IL
Speaker: Jeffrey Segall, PhD, Bronx, NY
In Vivo and Ex Vivo Tissue Applications of Two-Photon Microscopy
Speaker: Peter So, PhD, Cambridge, MA
Workshop 2 Room 6ED Download Handout
Large Animal Models for Orthopaedic Research: Possibilities and Limitations
Organizer: A. Simon Turner, BVSc, MS, Dipl ACVS, Ft. Collins, CO
For many years, the use of rats, mice, rabbits and other smaller animals have played vital roles in different phases of orthopaedic research and product development. A greater challenge for many investigators is moving to larger animals that have anatomical size, metabolic rate, and bone-joint-cartilage physiology closer to that seen humans. Other factors that now have to be taken into consideration using larger animals are convenience, availability, cost, humane aspects (including attention to pain management), and acceptability to society. This workshop will review some of the large animal models that are currently popular for orthopaedic research. Specifically, these animals include, dogs, sheep, goats, pigs, calves and horses. Discussions will include the translation to the human condition, the target population, what constitutes skeletal maturity, designing a particular study, as well as the strengths and weaknesses of the different models. Other practical issues presented will be, whether two legs can be used in the same animal, available endpoints, requirements for regulatory bodies such as FDA to mention just a few. The speakers at this symposium are veterinarians /ORS members that have spent most of their careers using large animal models for orthopaedic research. The first speaker will give some important historical background about the use of large animals and how this discipline has evolved into its present state. The second speaker will talk about equine models, a third speaker will focus on animal models of hip and knee replacement and the fourth speaker will present the practical aspects of orthopaedic research using sheep. Participants should leave the workshop with a better understanding of what large animal models to use (and what not to use) for their areas of interest.
Choosing Animal Models in Musculoskeletal Research: Scientific, Veterinary, and Practical Considerations
Speaker: Steven P. Arnoczky, DVM, Dipl ACVS, East Lansing, MI
Equine Models for Studying Osteoarthritis, Articular Cartilage Repair and Tendinopathy
Speaker: C. Wayne McIlwraith, BVSc, PhD, Dipl ACVS, Ft. Collins, CO
Animal Models of Hip and Knee Replacement
Speaker: Matthew J. Allen, BVMS, PhD, Syracuse, NY
Practical Aspects of Orthopaedic Research Using Sheep
Speaker: A. Simon Turner, BVSc, MS, Dipl ACVS, Ft. Collins, CO
Workshop 3 Room 6C Download Handout
Evolving Ideas in Spinal Cord and Peripheral Nerve Injuries: Neuroscience for Musculoskeletal Investigators
Organizer: Ranjan Gupta, MD, Irvine, CA
Recent advances in neuroscience challenge our existing ideas about neural regeneration after both spinal cord injury and peripheral nerve injury with the evolution of the concepts of neurogenesis, functional reinnervation, glial scar development, and the application of stem cell biology. As both neurosurgeons and orthopaedic surgeons are on the front line of treating these pathologic conditions, it is critically important that the orthopaedic community is cognizant of these advances as neuroscientists are currently developing human clinical trials to begin translational neuroscience interventions. After a brief review of relevant developmental neuroscience, we will provide an overview of current neuroscience data pertaining to both spinal cord injury and peripheral nerve injury.
Developmental NeuroscienceSpeaker: Ranjan Gupta, MD, Irvine, CA
Peripheral Nerve Injury
Speaker: Edward Diao, MD, San Francisco, CA
Spinal Cord Injury
Speaker: George M Smith, PhD, Lexington, KY
Workshop 4 Room 6F Download Handout
Xenografts: Biomaterials, Clinical and Regulatory Issues
ORS/ Society for Biomaterials/ Orthopaedic Device Forum Joint Workshop
Co-Organizers: Warren Haggard, PhD, Memphis, TN, and
Barbara D Boyan, PhD, Atlanta, GA
Xenotransplantation for musculoskeletal applications is rapidly progressing as the clinical need for tissue regeneration increases. The initial clinical results in using non-human tissue engineering scaffolds have been promising for replacing and repairing both soft and hard tissues. Advances in biology have also led to enhanced knowledge on tissue structure, organization and signaling necessary for tissue development and repair. Coupling these advances with new and novel biomaterials, these xenograft scaffolds are transforming research approaches and clinical applications for many musculoskeletal problems. The aims of this workshop are to summarize the current technologies and clinical uses, highlight unanswered questions and technical hurdles and discuss regulatory guidelines and research avenues.
Natural Extracellular Matrices for Rotator Cuff Repair
Speaker: Kathleen Derwin, PhD, Cleveland, OH
Clinical Perspectives and Rationale for Xenograft Scaffolds
Speaker: Russell F. Warren, MD, New York, NY
Regulatory Guidelines and Typical Questions for Use of the Xenograft materials in Musculoskeletal Applications
Speaker: Peter Hudson, FDA Speaker from CDRH
Non-Autologous ECM for Orthopedic Soft Tissue Reconstruction
Speaker: Stephen Badylak, Pittsburgh, PA
| TUESDAY, FEBRUARY 13 7:00 AM - 8:30 AM |
Workshop 5 Room 6B Download Handout
From Your Lab to the Market: Understanding the Industrial Product Development Pathway
Organizer: Scott P. Bruder, MD, PhD, Raynham, MA
A symbiotic relationship between academic and industrial investigators is essential for the development of new therapies to treat musculoskeletal injury and disease. The purpose of this workshop is to provide practical information and insights regarding the pathways and processes required to bring inventions to the commercial market. The workshop will start with an overview of the product development process required of medical device and pharmaceutical companies. Discussion of intellectual property, including the creation and value of patents, will follow. Since marketing approval of products is regulated by government agencies (e.g. FDA), an exposition of the various pathways for approval will also be provided. Lastly, we will describe the important scientific discipline required to translate lab scale implant formulation into reproducible and robust product manufacturing processes and controls. At the close of theworkshop, attendees will have a greater understanding of the multi-year, multi-step process required to commercialize new products, including the major costs, hurdles and timelines. This improved understanding has the potential to help the orthopaedic research community function even more effectively.
From Bench to Bedside: Understanding the Product Development ProcessSpeaker: Scott P. Bruder, MD, PhD, Raynham, MA
Creating Value for Your Inventions: Patent Fundamentals
Speaker: David S. Smith, Esq., Pittsburgh, PA
Pathways to the Commercial Market: Regulatory Requirements
Speaker: Aric D. Kaiser, MS, Rockville, MD
Converting Elegant Science to a Scalable Product: The Art of Process Development
Speaker: F. Jerry Volenec, PhD, Raynham, MA
Workshop 6 Room 6ED Download Handout
Distraction Osteogenesis – A Most Advanced Form of Tissue Engineering
Organizer: Gang Li, MBBS, DPhil (Oxon), Belfast, Northern Ireland
Induction of osteogenesis by means of an osteotomy, followed by fixation with an external fixator and subsequent controlled distraction of the callus, is a useful technique termed as distraction osteogenesis (DO) with widespread clinical applications and outstanding clinical outcomes in the treatment of bone defects, limb deformities and fracture non-unions. DO is probably the most advanced and cost-effective form of tissue engineering. This workshop aims to discuss recent advances in understanding the basic biological and biomechanical mechanisms of DO, clinical achievements of its applications, new methods of assessing and promoting bone consolidation during DO and new clinical applications of DO. DO technique has a wider implication in understanding human body’s self-repair and self-regeneration potentials and its new clinical applications are now extended to functional tissue engineering, management of soft-tissue injuries, treatment of vascular diseases and many other disease conditions.
Development and Insights Learned from Distraction Osteogenesis
Speaker: Gang Li, MBBS, DPhil (Oxon), Belfast, Northern Ireland
Clinical Achievements and Implications of Distraction Osteogenesis
Speaker: Dror Paley, MD, FRCSC, Baltimore, MD
Biomechanical Mechanisms and Considerations of Distraction Osteogenesis
Speaker: Lutz Claes, MSc, PhD, DHum Biol, Ulm, Germany
Changes of Gene Expression During Distraction Osteogensis- A Mechanistic Update
Speaker: Natsuo Yasui, MD, Tokushima, Japan
Workshop 7 Room 6C Download Handout
Radiostereometry (RSA): An Accurate Tool to Assess Micromotion of Orthopaedic Implants
Organizer: Johan Kaarholm, MD, PhD, Goteborg, Sweden
For more than three decades, radiostereometry has been used in a large number of clinical and experimental studies to accurately assess micromotion of orthopaedic implants. Because of its high accuracy, researchers are able to screen new developments in prosthetic design in small patients groups, thus preventing large groups of patients from being exposed to potentially inferior designs. As regulations for marketing new prostheses are becoming stricter, RSA might become one of the imposed evaluation techniques. In this symposium, the basics of RSA will be explained, and the results and impact of a number of clinical RSA studies is presented, as well as future developments.
Basics, Practical Issues and Clinical Results
Speaker: Johan Kaarholm, MD, PhD, Goteborg, Sweden
Clinical Studies and Impact of RSA Results
Speaker: Rob Nelissen, MD, PhD, Leiden, The Netherlands
New Developments and the Future of RSA
Speaker: Edward Valstar, PhD, Leiden, The Netherlands
Changes of Gene Expression During Distraction Osteogenosis - A Mechanistic Update
Speaker: Natsuo Yasui, MD, Tokushima, Japan
Workshop 8 Room 6F Download Handout
Environmental Agents Affecting the Skeleton: Unrecognized Contributors to Musculoskeletal Diseases
Organizer: J. Edward Puzas, PhD, Rochester, NY
The Accumulation of Fluoride Into Bone and its Effects on Bone Strength
Speaker: Charles H.Turner, PhD, Indianapolis, IN
The Accumulation of Lead in Bone and the Methods Used to Detect and Measure It
Speaker: David Chettle, PhD, Ontario, Canada
Overview of the Aryl Hydrocarbon Receptor and its Role in Mediating the Toxic Effects of Aromatic Hyrdocarbons
Speaker: Elizabeth Ryan, PhD, Rochester, NY
Characterization of the Aryl Hydrocarbon Receptor in Bone Cells and the Possible Implications of its Activation
Speaker: Elizabeth Ryan, PhD, Rochester, NY
| WEDNESDAY, FEBRUARY 14 |
The ORS/AAOS Combined Symposia will be held at the San Diego Convention Center.
8:00 AM - 10:00 AM
ORS/AAOS Combined Symposium I Room 6A
Orthopaedic War Injuries from Combat Casualty Care to Definitive Treatment: A Current Review of the Basic Science, Clinical Advances and Research Opportunities
Co-Moderators: Capt Dana C. Covey, MD, San Diego, CA and Roy K. Aaron, MD, Providence, RI
Over 20,000 U.S. service members have been wounded in the ongoing wars in Iraq and Afghanistan, approximately 70 percent of whom have musculoskeletal injuries, most of which are caused by exploding ordnance. This symposium will highlight the unique character of orthopaedic war wounds, treatment challenges on the frontlines and in subsequent definitive treatment, and basic science advances that may bear on potential treatment of these often devastating wounds which may also have broad applicability to trauma resulting from terrorism or natural disasters .
Blast Injury: Pathophysiology and Injury Patterns
Speaker: Christopher Born, MD
Battlefield Musculoskeletal Infections; Past, Present, Future
Speaker: Jason Calhoun, MD
Evolving Technologies for Enhancement of the Repair of Segmental Bone Defects
Speaker: Thomas Einhorn, MD, Boston, MA
Advances in Combat Amputee Care
Speaker: LTC. H. Michael Frisch, MD, Silver Spring, MD
New Developments in Soft Tissue Coverage of Massive Wounds
Speaker: L. Scott Levin, M, Durham, NC
Battlefield Damage Control: Prevention of the Second Hit
Speaker: CDR Michael T Mazurek, MD, San Diego, CA
Towards Novel Interventions of Osteomyelitis
Speaker: Edward Schwarz, PhD, Rochester, NY
The Needs and Opportunities for Pre-Clinical Orthopaedic Trauma Research
Speaker: Joseph C. Wenke, PhD, Fort Sam Houston, TX
Aeroevacuation Challenges and Advances; Negative Pressure Wound Management in the Air and the Effect of Altitude on Compartment Pressures
Speaker: Elisha T. Powell, MD, Elmendorf Afb, AK.
10:30 AM - 12:30 PM
ORS/AAOS Combined Symposium II Room 6A
Total Disc Arthroplasty: The Art and Science as of 2007
Co-Moderators: Scott D. Boden, MD, Atlanta, GA and Dawn M. Elliott, PhD, Philadelphia, PA
Painful degenerative disc disease is a widespread problem that has few surgical treatment options. While fusion has been replaced by arthroplasty in appendicular joints, fusion remains the standard of treatment for the spine.
Recent advances in disc replacement design and completion of FDA-regulated prospective randomized clinical trials have brought disc arthroplasty to the verge of approval and accessibility to the patient suffering from chronic low back pain. Nonetheless, disc arthroplasty remains a novel and controversial treatment with many questions associated with optimal biomechanical design, biomechanical and biological effect on adjacent disc levels, patient selection and exclusion criteria, and evaluation of patient satisfaction.
The first goal of this symposium is to review clinically relevant anatomy, biomechanics, and biology in healthy and degenerated intervertebral disc tissue.
In addition, balanced summaries of the current state of cervical and lumbar spine total disc arthroplasty will be presented, including clinical results. Future concerns and directions for research will be discussed.
Disc Anatomy and Biomechanics
Speaker: Ian A.F. Stokes, PhD, Burlington, VT
Disc Biology
Speaker: James D Kang, MD, Pittsburgh, PA
Cervical Spine Total Disc Arthroplasty
Speaker: John Heller, MD, Atlanta, GA
Lumbar Spine Total Disc Arthroplasty
Speaker: Jeffrey C Wang, MD, Los Angeles, CA