Workshops / Symposia
| Saturday, March 1 |
8:30 AM – 5:30 PM |
55 Fourth Street
Room: Salon 4-6
ORS/OREF Grant Writing Workshop
The ORS Mentoring Committee is pleased to present the 4th Annual Grant Writing Workshop at the ORS Annual Meeting in San Francisco. The course is designed for new investigators in the process of writing their first grant proposals, and will include a mock study section so investigators can see what is involved in NIH peer review. Attendees are encouraged to submit a grant to the ORS office. Two grants, one initial and one revised, will be chosen for review during the mock study section. The faculty has all been members of the NIH study section, and has participated in the ORS/OREF/AAOS sponsored Grant Writing Workshop held annually each spring.
The workshop will include introductory talks from NIAMS representatives, and discussions of each of the components of a R01 proposal from both a basic science and clinical research viewpoint. A mock study section will take place during lunch with faculty providing reviews. This will be followed by discussions of interpreting pink sheets, and what to do when you get your first grant.
($75 per person, includes continental breakfast, boxed lunch and syllabus.)
Registration is on a first-come, first-served basis. Registration is limited to 50 participants. Grant Writing Workshop Syllabus will be distributed to workshop attendees on-site.
Paperless Workshops Handouts ORS will have a limited number of stations to print handouts on-site. To avoid lines, we encourage you to make your selections in advance before arriving in San Diego. |
| Sunday, March 2 7:30 AM - 9:00 AM |
Workshop 1 Download Handout (PDF)
Osteoarthritis: The Impact of Sexual Dimorphism
Presented by the ORS Women's Leadership Forum
Co-Organizers: Adele L. Boskey, PhD, New York, NY and Barbara D. Boyan, PhD, Atlanta, GA
Many musculoskeletal conditions are impacted by the chromosomal sex of the patient. In this workshop, we will discuss one of the conditions that is more prevalent in women, osteoarthritis. While OA is predominant in men younger than 50 years of age, after age 50, the condition is more prevalent in women, particularly post-menopause. This has implications for diagnosis and treatment, as well as for joint replacement. A mouse model of OA in which female mice have less OA than males and OA severity increases following ovariectomy will be presented. An explanation for how sex hormones influence obesity, a discussion of how obesity impacts mechanical properties of the joints, and the clinical impact of sex-specific OA will also be discussed.
Sexual Dimorphism in Mouse Models of OA
Speaker: Sonya S. Glasson, BVSc, Cambridge, MA
Obesity and Gender-related Effects on Knee Biomechanics
Speaker: Amy L. Lerner, PhD, Rochester, NY
Workshop 2 Download Handout (PDF)
Impact of Environmental Factors on Intervertebral Disc Health
Organizer: Irving Shapiro, PhD, Philadelphia, PA
The incidence of low back pain, which is thought to be associated with degenerative changes in the disc, represents a major epidemiological problem. As many as 80% of adults will experience at least one episode of low back pain during their lifetime and 5% will experience chronic problems. Unfortunately, a clear understanding of the biological and clinical factors leading to degenerative disc disease remains elusive. Recent advances in the understanding of tissue repair have served to identify and clarify the possible roles of specific regulatory and structural molecules in disc degeneration and repair. More recently, there has been a focus on the role of local environmental factors in maintaining the health of the disc cells. The workshop will explore the biological role of these factors in relationship to disc health.
Osmotic and Oxemic Regulation of Disc Cell Function
Speaker: Makarand V. Risbud, Philadelphia, PA
TNF Alpha and Intervertebral Disc Degeneration
Speaker: Rita Kandel, MD, Toronto, ON, Canada
The role of adult stem cells in degeneration and regeneration of the intervertebral disc
Speaker: Dan Gazit, PhD, Jerusalem, Israel
Workshop 3 Download Handout (PDF)
Epigenetic Regulatory Mechanisms in Musculoskeletal Development and Disease
Organizer: Matthew Stewart, PhD, Urbana, IL“Epigenetics” refers to gene regulatory processes that result in heritable phenotypic changes that do not require DNA sequence alterations (mutations). Epigenetic processes impact gene expression by physically altering the conformation and/or organization of the genome. This predominantly occurs through methylation of cytosines within the promoter and exonic regions of genes, post-translational alterations to histone proteins within nucleosomes and through chromatin compaction. Epigenetic regulation of gene expression is critical to a wide range of cellular processes including normal vertebrate development, gene imprinting, X chromosome inactivation, and the development of many cancers. The importance of epigenetics in the musculoskeletal biology has received relatively little attention until recently, but the available data indicate that epigenetic regulation is important in the differentiation of mesenchymal lineages, skeletal development and the pathophysiology of diseases such as osteoarthritis.
Epigenetic Modifications as Pharmaceutical Targets
Speaker: Peter L. Jones, Urbana, IL
Epigenetic Regulation of Cartilage Development and its Application to Joint Disease Therapy
Speaker: Hiroshi Asahara, MD, PhD, La Jolla, CA
Are Diseases of Cartilage Due to Epigenetic Events?
Speaker: David J. Hall, PhD, Bethesda, MD
Wnt Signaling in Skeletal Development and Diseases
Co-Organizers: Motomi Enomoto-Iwamoto, DDS, PhD, Philadelphia, PA and Hicham Drissi, PhD, Rochester, NY
Recent studies have firmly established that Wnt signaling is essential for skeletal development, growth and morphogenesis. Strict regulation of this signaling pathway is required for skeletal patterning and formation of initial cartilaginous structures, development of synovial joints, and completion of endochondral and intramembranous bone formation. Multiple efforts throughout the international musculoskeletal research community are currently focused on establishing the mechanisms by which the Wnt signaling pathways exert such critical effects on bone and cartilage. Most of these investigations are dedicated to understanding how Wnt signaling cooperates with, and is modulated by, other signaling pathways. There is also a growing body of evidence that dysfunction of Wnt signaling results in serious skeletal conditions including arthritis. Thus, the purpose of this workshop is to bring these timely and exciting research developments to the full attention of our Society members. It is our purpose to not only educate and publicize novel findings, but also stimulate the imagination of, and possibly recruit, young members to this emerging field of biomedical skeletal research. Established investigators will greatly benefit as well and may be stimulated to test and analyze relevance and implications of the Wnt pathway in their specific areas of biomedical and clinical skeletal and orthopaedic research.
Wnt Signaling in Chondrocyte Differentiation)
Speaker: Regis J. O'Keefe, MD, PhD, Rochester, NY
Synoveal Joint Development and Wnt Signaling
Speaker: Yingzi Yang, PhD, Bethesda, MD
Wnt Signaling in Arthritis Pathogenesis: Evolving Concepts
Speaker: Malini Sen , Kolkata, India
| Monday, March 3 7:30 AM - 9:00 AM |
Workshop 5 Download Handout (PDF)
Wear Resistant Polyethylene for Joint Replacement: Current Status and Future Directions
ORS/Society for Biomaterials/Orthopaedic Device Forum Joint Workshop
Co-Organizers: Warren O. Haggard, PhD, Memphis, TN and A. Seth Greenwald, D. Phil. (Oxon), Cleveland, OH A number of more wear resistant “crosslinked” polyethylenes for use as bearing surfaces in hip and knee prostheses were introduced into clinical use during the past ten years, and the earliest of these now have clinical follow-ups exceeding five years. The purpose of this workshop will be to review the technical similarities and differences among the various versions in clinical use, to discuss the tradeoffs involved (such as the reduction in wear rate vs. the need to preserve adequate strength and toughness), the differences between formulations intended for use in hips vs. knees, the clinical performance to date (including the wear rates, the incidence of osteolysis and the incidence of fracture of the components), an evaluation of the accuracy by which the earlier joint simulator testing predicted this clinical performance, and an overview of the more recent “2nd generation” crosslinked polyethylenes. The goal will be to provide the orthopaedic surgeon and researcher with a thorough understanding of the technology underlying the new crosslinked polyethylenes and how this has (or might) effect their clinical performance, to enable the surgeon to make an informed decision regarding which, if any, of these materials would be appropriate for each patient.
Crosslinked Polyethylenes: A Convincing Laboratory Performance
Speaker: Speaker: Harry McKellop, PhD, Los Angeles, CA
In-Vivo RSA Assessment of Conventional and Highly Crosslinked Polyethylenes
Speaker: Henrik Malchau, MD, PhD, Boston, MA
Crosslinked Polyethylenes: Where the Faults May Lie
Speaker: Michael D. Ries, MD, San Francisco, CA
Clinical Performance of Crosslinked Polyethylenes: Where the Future is!
Speaker: Thomas P. Schmalzried, MD, Los Angeles, CA
Not so Fast: Clinical Performance of Conventional Polyethylenes
Speaker: Thomas P. Sculco, MD, New York, NY
Workshop 6 Download Handout (PDF)
Assessment of Fracture Healing in Clinical Trials: Methodological Challenges
Co-Organizers:Emil H. Schemitsch, MD, Toronto, ON, Canada and Theodore Miclau, MD, San Francisco, CAThe determination of fracture union is not only clinically important, but is also essential for outcomes research in fracture treatment. While there are many methods for assessing fracture healing in clinical studies, there is no consensus on what are the most valid and reliable ways to determine union, which outcomes are the most important, or what fracture models are the most relevant. This joint ORS/OTA symposium reviews the current methodological challenges in defining, measuring, and determining fracture healing, as well as addresses fundamental issues that affect the design of clinical trials in fracture repair.
Fracture Healing Defined: Is There a Consensus?
Speaker: Theodore Miclau, MD, San Francisco, CA
Measurement Error: Who Should Measure Healing in Clinical Research?
Speaker: Paul Tornetta, III MD, Boston, MA
Which Radiographic Measure Should We Use? Feasibility and Relevance
Speaker: Harry K. Genant, MD, Tiburon, CA
What Outcomes Should We Measure: Beyond the X-Ray?
Speaker: Marc F. Swiontkowski, MD, Minneapolis, MN
Clinical Trials in Fracture Healing: Methodological Challenges
Speaker: Mohit Bhandari, MD, Hamilton, ON, Canada
Workshop 7 Download Handout (PDF)
Systems Biology Approaches for Studying the Genetic Basis of Complex Conditions
Organizer: Karl J. Jepsen, PhD, New York, NY Understanding how gene variants ultimately lead to disease susceptibility is critical for the long-term goal of using genetic information for diagnostic and therapeutic purposes. The goal of this workshop is to introduce new approaches that are currently being used to understand the interactions between genetic variation and systems properties in complex traits.
Modifier Genes: Simple Traits and Complex Systems, In Sickness and In Health
Speaker: Joseph H. Nadeau, PhD, Cleveland, OH
Bone Mechanics, Muscle Mass, and Activity-Related Behavior: Structural Equation Modeling of their Relationships and Genetic Influence
Speaker: Dean H. Lang, PhD, University Park, PA
Genetic Randomization Reveals Co-adapted Traits that Contribute the Functionality and Fragility of Long Bone
Speaker: Karl J Jepsen, PhD, New York, NY
Workshop 8 Download Handout (PDF) Download TMJ Association's TMJ Science Handout (PDF)
Pain as a Critical Component to Understanding Musculoskeletal Disorders - TMJDs as a Model
Organizer: Stephen L. Gordon, PhD, Bethesda, MD Pain is the leading symptom on presentation for treatment of musculoskeletal conditions. The total economic impact of pain for all medical conditions exceeds $100B. Scientists have uncovered new mechanistic understanding of pain receptors, signal modification, and brain interpretation of the pain sensation. Additionally, there is emerging information on the population and protein level influence of genetic predisposition for stronger than normal perceptions of pain. This workshop will provide a review of key aspects of the status of pain research and possibly stimulate interdisciplinary research related to pain. Temporomandibular joint and muscle disorders (TMJDs) serve as a well-studied model system that is broadly representative of many joint structures in the body.
Joint Innervation by Nociceptors
Speaker: Peter Grigg, PhD, Worcester, MA
Spinal Cord and Brain Processing of Pain Signals
Speaker: Ronald Dubner, Baltimore, MD
Genetic Basis for Differences in Pain Perception
Speaker: William Maixner, Chapel Hill, NC
The TMJ Association's TMJ Science publication summarizes the meeting proceedings and recommendations from our May 2002 meeting, "Joint and Muscle Dysfunction of the Temporomandibular Joint", held in Bethesda MD.
| Wednesday, March 5 |
The ORS/AAOS Combined Symposia will be held at the Moscone West Convention Center.
Please note the correct listing below for the combined symposia. The two have been switched since the printing of the meeting announcement.
8:00 AM - 10:00 AM
ORS/AAOS Combined Symposium I
Biologic Strategies to Grow Bone in Difficult Clinical Situations
Faculty:
Moderator: Stuart B. Goodman, MD, Stanford, CA
Steve Goldstein, PhD, Ann Arbor, MI
Scott Boden, MD, Atlanta, GA
George F. Muschler, MD, Cleveland, OH
Jay Lieberman, MD, Los Angeles, CA
Harvinder S. Sandhu, MD, New York, NY
J. Tracy Watson, MD, St. Louis, MO
Alan W. Yasko, MD, Chicago, IL
Clinicians are gaining increased access to biologic strategies to grow bone in difficult clinical situations. These primary strategies include the use of stem cells and osteoprogenitors, and bone morphogenetic proteins. Unfortunately, these technologies are not formally tested initially in some of the tougher, clinically challenging situations or during "off-label" use. The primary goals of this symposium are to educate clinicians about the use of these technologies in tough clinical situations, highlight some of the local side effects of these technologies, and consider strategies to avoid complications. In addition, this symposium will identify areas that need further basic science research to facilitate the successful use of these biologic strategies.
10:30 AM - 12:30 PM
ORS/AAOS Combined Symposium II
Hip Resurfacing: Art and Science as of 2008
Faculty:
Moderator: William A. Jiranek, MD, Richmond, VA
Organizer: Paul E. Beaulé, MD, Ottawa, Canada
Organizer: Patricia A. Campbell, PhD, Los Angeles, CA
Joshua J. Jacobs, MD, Chicago, IL
Paul F. Lachiewicz, MD, Chapel Hill, NC
John B. Medley, PhD, Waterloo, Canada
Kevin Ong, Ph.D. Philadelphia, PA
Metal on metal hip resurfacing is now being offered to patients who are relatively young and want to maintain a high activity level. There is early clinical experience in Europe and Australia. However, there are questions regarding patient selection, optimal implant positioning and surgical technique, and there are controversies relating to the importance of femoral head vascularity, implant design, metallurgy and cement technique. This symposium will address these questions, controversies, and concerns. Current clinical results will be reviewed as they relate to patient selection, anatomy and vascularity of the femoral head. The issues of component wear and wear products will be examined from the tribological and biological perspectives. Failure mechanisms will be examined. Bone remodeling after resurfacing will be addressed using finite element models and measurements of remodeling using microQ-CT and histology. Together, this symposium will provide surgeons and researchers with an up-to-date review of the art and science of hip resurfacing.