Workshops / Symposia
All workshops will be held at The Venetian.| Sunday, February 22 8:00 AM - 9:30 AM |
Workshop 1 Room: Titian Download Handout
Emerging Imaging Tools To Characterize Cartilage Damage
Co-Organizers: Markus A. Wimmer, PhD, Chicago, IL and Carol Muehleman, PhD, Chicago, IL
Articular cartilage exhibits limited capacity for self-repair, so that advanced stages of osteoarthritis result in progressive cartilage damage and degradation, leading causes of disability. To better understand the etiology and progression of the disease, studies that incorporate longitudinal assessments of tissues would be helpful in the laboratory, as well as in clinical practice. This workshop focuses on unique, emerging in situ imaging tools that demonstrate potential in the evaluation of cartilage damage in the laboratory from the macro- to the nano-scale.
Phase Sensitive X-ray Imaging
Speaker: Carol Muehleman, PhD, Chicago, IL
Infrared Spectral Assessment of Cartilage in Situ
Speaker: Nancy Pleshko, PhD, Philadelphia, PA
Cartilage Surface Topography Measured with Scanning White Light Interferometry
Speaker: Michel P. Laurent, PhD, Chicago, IL
Nanoscale-Assessment Of Cartilage Matrix Constituents Using Atomic Force Microscopy
Speaker: Alan J Grodzinsky, ScD, Cambridge, MA
Workshop 2 Room: Venetian GH Download Handout Part 2 Part 3
Primary Cilia: The Cell's Antenna for Sensing the External Environment?
Co-Organizers: Cornelia E. Farnum, DVM, PhD, Ithaca, NY and Christopher R. Jacobs, PhD, Stanford, CA
Although primary cilia are virtually ubiquitous in mammalian cells, their function has only recently started to be elucidated. In musculoskeletal tissues specifically, there is increasing evidence that primary cilia act as cellular sensors of biochemical and biophysical signals. The primary cilium is described as the cell’s antenna – an organelle hypothesized to receive sensory information from the cellular environment and relay it to signal transduction pathways to change gene expression. The presence of a single cilium has been established for multiple epithelial, nervous, muscle, and skeletal tissue cells. Its role as a mechanosensor is being actively investigated in multiple organ systems, and human diseases have been associated with mutations of some of the ~800 ciliary-based proteins. This workshop will begin with an overview of experimental systems used in the past decade to investigate the primary cilium, with a focus on understanding the relationship between primary cilium function and human disease. This will be followed by specifically examining current hypotheses concerning the role of primary cilia in bone cells and cells of other skeletal tissues, including articular and growth plate cartilage.
Molecular and Cellular Insights into the Ciliopathies
Speaker: Bradley K. Yoder, PhD, Birmingham, AL
Primary Cilia as Mechanosensors in Bone
Speaker: Christopher R. Jacobs, PhD, New York, NY
Primary Cilia in Chondrocytes: The Matrix-Cilium-Golgi Continuum
Speaker: Anthony Poole, PhD, Dunedin, New Zealand
Workshop 3 Room: Venetian IJ Download Handout
Preclinical Considerations for Orthopedic Product Development
Presented by the ORS Corporate Affairs Committee
Co-Organizers: Gabriele G. Niederauer, PhD, San Antonio, TX and Gloria L. Matthews, DVM, PhD, Framingham, MA
The purpose of this workshop is to provide critical information on animal study design and related preclinical testing required to bring orthopedic products to the commercial market. The topics reviewed in this workshop are significant to provide the orthopedic researcher with the necessary tools to evaluate and develop marketable products.
Comparative Animal Anatomies and How to Select the Best Model for Your Product Development
Speaker: Harold M. Aberman, DVM, MSE, West Chester, PA
Relevant Standards and How they can Help Achieve Approval for Starting Clinical Studies
Speaker: Richard D. Coutts, MD, San Diego, CA Dr. Coutt's PowerPoint Presentation
Navigating the FDA Including Premarket Approval of Medical Products, Combination Products Regulation, and Product Development
Speaker: Janice M. Hogan, JD, BSME, Philadelphia, PA
Workshop 4 Room: Veronese A Download Handout
Physical Activity Assessment- Monitoring Patients During Activities of Daily Living
Organizer: Dieter Rosenbaum, PhD, Muenster, Germany
The quantification of patients’ physical activity during their daily life is a valuable and objective measure of the functional outcome after treatment and interventions for a variety of orthopaedic problems. The workshop will provide an overview of existing methods and instrumentation, relevant areas of application, and the analysis and interpretation of activity data. Furthermore, assistance in choosing the appropriate device for specific patient populations is provided.
Monitoring Technology for the Assessment of Physical Activity in the Field
Speaker: Gregory J. Welk, PhD, Ames, IA
Applications of Activity Monitoring for Epidemiology and Public Health Research
Speaker: Soren Brage, PhD, Cambridge, United Kingdom
Applications for Ambulatory Montoring for ADL Assessment in Orthopaedic Patients
Speaker: Dieter Rosenbaum, PhD, Muenster, Germany
| Monday, February 23 8:00 AM - 9:30 AM |
Workshop 5 Room: Titian Download Handout
Orthopaedic Complications in Animal Models of Aging
Organizer: Christopher H. Evans, PhD, Boston, MA
Aging is associated with tissue degeneration as well as a reduced capacity for regeneration. For orthopaedics, age-related pathologies include disc degeneration, osteoporosis, osteoarthritis and poor healing of bone fractures. Only recently have some of the cellular changes that occur with aging been identified. These include accumulation of damage, including DNA damage, in adult stem and progenitor cells, which limits tissue repair. The purpose of this workshop is to provide a current overview of animal models of aging, including accelerated aging, and the state of analysis of age-related defects in bone healing, disc degeneration and chondrogenesis.
Mouse Models of Accelerated Aging: Orthopaedic Complications
Speaker: Laura J. Niedernhofer, MD, PhD, Pittsburgh, PA
Delayed Bone Repair in Aged Animals is Associated with Altered Cellular and Molecular Signals
Speaker: Regis J. O'Keefe, MD, PhD, Rochester, NY
Aging Changes in Animal and Human Chondrocytes
Speaker: Joseph A. Buckwalter, MD, Iowa City, IA
Lapine and Murine models of Disc Degeneration and Aging
Speaker: James D. Kang, MD, Pittsburgh, PA
Workshop 6 Room: Venetian GH Download Handout
BMPs: Current Evidence and Future Solutions
ORS/Orthopaedic Trauma Association Joint Workshop
Co-Organizers: Emil H. Schemitsch, MD, Toronto, Canada and Theodore Miclau, III, MD, San Francisco, CA
The use of an autogenous iliac crest bone graft remains the gold standard for the treatment of bone defects and non-unions, but there are significant limitations to autogenous bone grafting. Recombinant bone morphogenetic proteins (BMPs) are commercially available, and with growing clinical experience, are further emerging as viable bone graft substitutes. This symposium reviews the current clinical evidence on the use of BMPs to treat fresh open tibia fractures and non-unions, as well as addresses what work still remains to assess the effectiveness of these proteins.
Are BMPs the Same?
Speaker: Thomas A .Einhorn, MD, Boston, MA
Role of BMPs: Nonunions: “Should they be standard of care?”
Speaker: Emil H. Schemitsch, MD, Toronto, Canada
Role of BMPs: Open Tibial Fractures: “Are costs worth the benefits?”
Speaker: Marc F. Swiontkowski, MD, Minneapolis, MN
Role of BMPs: Bone Defects: “Do they work?”
Speaker: Alan L. Jones, MD, Dallas, TX
Future Directions: “Is the current evidence good enough?”
Speaker: Mohit Bhandari, MD, Hamilton, Canada
Workshop 7 Room:Venetian IJ Download Handout
The Art of Bone and Cartilage Histology and Histomorphometry
Presented by the ORS Women’s Leadership Forum
Co-Organizers: Gloria Gronowicz, PhD, Farmington, CT and Cathy S. Carlson, DVM, PhD, and Diplomate ACVP, St. Paul, MN
The purpose of this workshop is to present basic and new techniques for evaluating the morphology of bone and cartilage. Optimal methods for preservation of cartilage and bone in different experimental conditions, as well as due to artifactual changes, will be discussed. The standard nomenclature, symbols and units for bone histomorphometry devised by the American Society for Bone and Mineral Research Histomorphometry Nomenclature Committee in 1987 will be reviewed. Sampling techniques that allow objective and reproducible evaluation of different skeletal sites and tissue engineering constructs will be presented. Various animal models will be used to illustrate how to assess the quality and activity of the cartilage and bone for diseases such as osteoarthritis and osteoporosis and due to radiation damage. In addition, the similarities and differences in assessing bone remodeling rates in human skeletal tissue compared to other animals will be discussed.
Optimizing the Quality of Morphological Assessments of Cartilage
Speaker: Cathy S. Carlson, DVM, PhD, Diplomate ACVP, St. Paul, MN
Why Perform Bone Histomorphometry in the Age of microCT?
Speaker: Urszula T. Iwaniec, PhD, Corvallis, OR
Lessons from Histology/Histomorphometry of Mouse Transgenic Models for Human Diseases
Speaker: Gloria A. Gronowicz, PhD, Farmington, CT
Workshop 8 Room: Veronese A Download Handout
Biomaterials for Tendon and Ligament Repair: Current Status and Future Directions
ORS/Society for Biomaterials/Orthopaedic Device Forum Joint Workshop
Co-Organizers: Lynne C Jones, PhD, Baltimore, MD and Jack E Lemons, PhD, Birmingham, AL
Surgical repair with biomaterials of musculoskeletal soft tissues, especially tendons and ligaments, is rapidly increasing and expanding with our active and aging populations. The past clinical results using biomaterial scaffolds and replacements have been promising, but were not clinically effective long-term. Advances in biology and material understandings that are being coupled with the novel biological active scaffolds are transforming research & development approaches for these soft tissue repairs. The aims of this workshop are to summarize the current technologies and clinical uses and highlight unanswered questions and technical hurdles for future directions.
Scaffolds as Biomechanical Adjuncts for Tendon and Ligament Repair
Speaker: Kathleen Derwin, PhD, Cleveland, OH
Ligament and Tendon Scaffold Lessons from the Past and Impacts on the Future
Speaker: Warren O. Haggard, PhD, Memphis, TN
Clinical Applications of Biologic Grafts in Orthopaedics
Speaker: Scott Steinmann, MD, Rochester, MN
Panel Discussion: Next Steps for Enhancing Soft Tissue Repair of Tendons and Ligaments
Paperless Workshop Handouts ORS will have a limited number of stations to print handouts on-site. To avoid lines, we encourage you to make your selections in advance before arriving in Las Vegas. |
| Wednesday, February 25 |
8:00 AM - 10:00 AM
ORS/AAOS Combined Symposium I Room: Venetian Ballroom IJ
Current Controversies in Bearing Surface Science
Moderator: Joshua J. Jacobs, MD, Chicago, IL
The US orthopaedic surgical community is now approaching a decade of clinical experience with the so-called alternative bearing surfaces for joint replacement applications. This symposium will present the state-of-the-science as it relates to arthroplasty of the hip, knee and intervertebral disc with a focus on challenges and opportunities regarding clinical performance, material performance, and tribology.
Speakers:
Clinical Performance of Modern Bearing Couples
Speaker: Stuart Goodman, MD, PhD, Stanford, CA
Highly Cross-linked Polyethylene: Challenges and Opportunities
Speaker: Clare Rimnac, PhD, Cleveland, OH
Tribology of Ceramic Bearings: Challenges and Opportunities
Speaker: William Walter, MD, PhD, Waverton, Australia
Tribology of Metal on Metal Bearings: Challenges and Opportunities
Speaker: Markus Wimmer, PhD, Chicago, IL
Performance of Artificial Disc Bearings
Speaker: Steven Kurtz, PhD, Philadelphia, PA
10:30 AM - 12:30 PM
ORS/AAOS Combined Symposium II Room: Venetian Ballroom IJ
Hyaline Cartilage Biological Joint Repair, Restoration and Resurfacing
Moderator: Dennis Crawford, MD, Portland, OR
Efforts to address the clinical entity of chondral and osteochondral injury hold the promise to “cure” pre-arthritic conditions and ameliorate arthritic conditions. However, which therapy to use, and under what circumstances, remain significant challenges for both scientist and clinician. In this symposium, a series of discussions will consider the nature of joint injury involving hyaline cartilage and address strategies to resolve pathology in the complex diarthrodial joint tissue environment. A focus on evidence based approaches will be used to guide two separate panel discussions on emerging therapies and the best guidelines for current techniques.
Hyaline Cartilage Health: Risks Factors Associated with Cartilage Injury and Progression to “Degenerative” Osteoarthritis.
Speaker: Joseph A. Buckwalter, MD, Iowa City, IA
Factors Influencing Chondrocyte Function and Cartilage Homeostasis in the Joint
Speaker: Hubert Kim, MD, San Francisco, CA
Historical Overview of Cartilage Repair Therapies, Approaches and Emerging, Strategies.
Speaker: Bert Mandelbaum, MD, Santa Monica, CA
Panel Discussion I: Translating Basic Science to Curative Therapuetics for Cartilage Biology and Pathology: Can we cure Arthritis?
Panel: Joseph A. Buckwalter, MD, Hubert Kim, MD and Bert Mandelbaum, MD
Clinical Considerations for Assessing the Potential of Cartilage Restoration Surgery
Speaker: William Bugbee, MD, La Jolla, CA
Osteochondral Replacement Strategies: Autogenous and Allogeneic
Speaker: Riley Williams, MD, New York, NY
1st & 2nd Generation Cartilage Repair: Debridement to Cloned Cell Implantation
Speaker: Kai Mithoefer, MD, Boston, MA
3rd & Next Generation Cartilage Repair: Matrix, Scaffolds and Tissue Systems
Speaerk: Marc Safran MD, Stanford, CA
Panel Discussion II: Surgical Care Algorithms for Cartilage Injury: Treatment Approaches, Indications and Staging
Panel: William Bugbee, MD, Riley Williams, MD Kai Mithoefer, MD and Marc Safran