New Spotlight Sessions
The ORS has invited experts in various research fields to give 25-minute talks about their latest work. Four related 10-minute talks drawn from the accepted abstract pool will complete the session.
| Saturday, March 6 1:45 PM - 3:15 PM |
Spotlight Session 16 Enzymes in Arthritis
Room: Auditorium A
1:45 PM (Please note late change in Spotlight Speaker)
Spotlight Speaker: Amanda J Fosang, PhD, Victoria, Australia
Aggrecanase, Collagenase, Hyaluronidase
2:15 PM
Paper No. 71
Mechanism of mechanosensitive transcriptional suppression of MMP-1: CITED2 competes with ETS1 for binding to the co-activator p300
Daniel Leong, Yonghui Li, Zhengzhe Li, Philip Nasser, Robert Majeska, Mary Goldring, Hui Sun
2:30 PM
Paper No. 72
Cytokine regulation of aggrecanase mRNA expression and activity in primary mouse chondrocytes
Fraser Rogerson, Yuen Chung, Michael Deutscher, Leonie Tutolo, Karena Last, Amanda Fosang
2:45 PM
Paper No. 73
Pro-inflammatory cytokine expression in synovium, synovial fluid, and articular cartilage of naturally osteoarthritic equine carpi
Jennifer Kamm, Thomas Witte, Alan Nixon
3:00 PM
Paper No. 74
Endogenous Aggrecanase-1 Activity in Synovial Fluids in Patients with Joint Disease
Helena Evans, Bruce Caterson, Annie Kerr, Sally Roberts
Spotlight Session 17 Joint Function
Room: Auditorium B
1:45 PM
Spotlight Speaker: Scott Tashman, PhD, Pittsburgh, PA
Assessing Dynamic Joint Function: New Tools for Understanding Musculoskeletal Injury, Disease and Treatment
Paperr No. 75
In Vivo Graft Deformation in Transtibial and Tibial Tunnel Independent ACL Reconstruction Techniques
Ermias Abebe, Gangadhar Utturkar, Jong Kim, Charles Spritzer, Claude Moorman, Dean Taylor, William Garrett, Louis DeFrate
2:30 PM
Paper No. 76
Cartilage Contact Characteristics in Anterior Cruciate Ligament Deficiency
Samuel Van de Velde, Thomas Gill, Guoan Li
2:45 PM
Paper No. 77
In-Vivo Joint Mechanics, Shoulder Strength, And Their Interaction After Rotator Cuff Repair: 2-Year Follow-Up
Michael Bey, Stephanie Kline, Kristin Ciarelli, Jessica Deneweth, Patricia Kolowich, Terrence Lock, Vasilios Moutzouros
3:00 PM
Paper No. 78
Bilateral below knee amputee socket-stump kinematics using Biplane Dynamic Roentgen Stereophotogrammetric Analysis
George Papaioannou, Christos Mitrogiannis, George Nianios, Goeran Fiedler
Spotlight Session 18 Osteoclastogenesis
Room: Auditorium C
1:45 PM (Please note late change in Spotlight Speaker)
Spotlight Speaker: Edward M Greenfield, PhD, Cleveland, OH
Regulation of Osteoclast Differentiation
2:15 PM
Paper No. 79
microRNA-146 inhibit osteoclast differentiation
Tomoyuki Nakasa, Hayatoshi Shibuya, Yoshihiko Nagata, Takuya Niimoto, Mitsuo Ochi
2:30 PM
Paper No. 80
Nuclear Factor of Activated T Cells (NFAT) Regulates Innate Inflammatory Response By Monocyte/Macrophage-Lineage Cells
Hiroshi Minematsu, Mike Shin, Ayse Aydemir, Francis Lee
2:45 PM
Paper No. 81
Osteoclast Development and Skeletal Remodeling Requires PTPase Shp2
Wentian Yang, Douglas Moore, Kai Zhao, Mauricio Valdes, Shigeaki Kato, Qian Wu, Peter Quesenberry, Qian Chen, Michael Ehrlich
3:00 PM
Paper No. 82
Connexin 43 in Osteocytes but not Osteoblasts Regulates Osteoclast Formation and Bone Resorption via the RANKL Pathway
Yue Zhang, Emmanuel Paul, lubov grigoryeva, Henry Donahue
Spotlight Session 19 Tendon
Room: 291-292
1:45 PM
Spotlight Speaker: Ronen Schweitzer, PhD
Between a Muscle and a Hard Bone - Regulation of Tendon Induction and Differentiation
2:15 PM
Paper No. 83
Mouse Treadmill Running Stimulates Tendon Stem Cell Division and Collagen Production
Jianying Zhang, Tiffany Pan, James Wang
2:30 PM
Paper No. 84
Bone marrow-derived mesenchymal cells transduced with scleraxis improve rotator cuff healing in a rat model
Lawrence Gulotta, David Kovacevic, Jonathan Packer, Xiang Deng, Scott Rodeo
2:45 PM
Paper No. 85
Characterization of embryonic tendon elasticity and morphology using atomic force microscopy
Joseph Marturano, Jeffrey Arena, Catherine Kuo
3:00 PM
Paper No. 86
Embryonic Stem Cells Improve Tendinitis Repair in a Large Animal Model
Ashlee Watts, Amy Yeager, Oleg Kopyov, Alan Nixon
Spotlight Session 20 Stem Cell Differentiation
Room: 293-296
1:45 PM
Spotlight Speaker: Henry J Donahue, PhD, Hershey, PA
Optimizing Adult Stem Cells for Musculoskeletal Regeneration
2:15 PM
Paper No. 87
Long-term cultivation maintains age-related differences in functional behaviour and protein expression but negatively affects the differentiation potential of MSCs
Sven Geissler, Georg Duda, Lei Mao, Jessica Trippens, Olga Sheshukova, Liliya Schumann, Cameron Wilson, Madeleine Diedrich, Joachim Klose, Grit Kasper
2:30 PM
Paper No. 88
Conversion of Transformed Stem Cells to Osteogenic Cells Using SIRNA
Denise Barry, Arvydas Usas, Uchenna Nwosu, Jin Jen, Johnny Huard, Jonathan Pollett
2:45 PM
Paper No. 89
Synergistic Effect of rhBMP-2 and osteopontin Derived Peptides Grafted to a Hydrogel Substrate on Osteogenesis of Marrow Stromal Cells
Junyu Ma, Xuezhong He, Esmaiel Jabbari
3:00 PM
Paper No. 90
Acceleration of Bone Formation in Large Bony Defect using Magnetically labeled Mesenchymal Stem Cells with a Magnetic Targeting System
Seigo Oshima, Masakazu Ishikawa, Yu Mochizuki, Takaaki Kobayashi, Yuji Yasunaga, Mitsuo Ochi
| Sunday, March 7 2:45 PM - 4:15 PM |
Spotlight Session 26 Tissue Engineering
Room # Auditorium A
2:45 PM
Spotlight Speaker: Prof. Anthony Peter Hollander, PhD, Bristol, UK
Cartilage Tissue Engineering From Stem Cells: Turning Science Into Medicine
3:15 PM
Paper No. 121
Functional Maturation of Engineered Composites that Mimic the Hierarchical Organization of the Intervertebral Disc
Nandan Nerurkar, Sounok Sen, Alice Huang, Dawn Elliott, Robert Mauck
3:30 PM
Paper No. 122
Comparison of Stem Cells Isolated from Human Anterior Cruciate Ligament and Bone Marrow
Ming-Te Cheng, Tain-Shung Chen, Oscar Kuang-Sheng Lee
3:45 PM
Paper No. 123
Reducing Expression of P65 Improved Success of Muscle stem Cells Transplantation by attenuating inflammation
Aiping Lu, Ying Tang, Jonathan Proto, Paul Robbins, Johnny Huard
4:00 PM
Paper No. 124
The Clinical Use of Human Autologous Bone Marrow Derived Mesenchymal Stem Cells Transplanted on Platelet-Rich Fibrin Glue in the Treatment of Articular Cartilage Defects
Amgad Haleem, Constance Chu, Abdel Aziz El Singergy, Dina Sabry, Hazem Atta, Laila Rashed, Mohammed El Sewy, Akram Azzam, Mohammed Abdel Aziz
Spotlight Session 27 Development and Disease
Room: Auditorium B
2:45 PM
Spotlight Speaker: Benjamin Alman, MD, Toronto, Canada
From Development to Disease: Hedgehog in Tumors and Arthritis
3:15PM
Paper No. 125
Primary Cilia are Required for IHH Signal Transduction in Response to Hydrostatic Loading of Growth Plate Chondrocytes
Yvonne Shao, Lai Wang, Jean Welter, Tracy Ballock
3:30 PM
Paper No. 126
Activation of Indian Hedgehog Promotes Chondrocyte Hypertrophy and Upregulation of MMP-13 in Osteoarthritic Cartilage
Lei Wei, Fangyuan Wei, Jingming Zhou, xiaochun wei, Wesley Wu, Qian Chen
3:45 PM
Paper No. 127
Smoothened as a New Therapeutic Target for Human Osteosarcoma
Osamu Kunigou, Takao Setoguchi, Masataka Hirotsu, Yukihiro Matsunoshita, Setsuro Komiya
4:00 PM
Paper No. 128
Microarray Analysis of Upstream Hedgehog Genes Provide Potential Radiorecovery Targets
Jason Horton, Meredith Pritchard, Timothy Damron, Frank Middleton, Joseph Spadaro
Spotlight Session 28 Clinical Trials
Room: Auditorium C
2:45 PM
Spotlight Speaker: Mohit Bhandari, MD, Ontario, Canada
Moving from the Bench to the Bedside: Designing Modern Day Clinical Trials in Fracture Healing
3:15 PM
Paper No. 129
A Randomized, Double-Blind, Placebo-Controlled Trial of Local Application of Recombinant Human Fibroblast Growth Factor-2 for Tibial Shaft Fractures
Hiroshi Kawaguchi, Takashi Matsushita, Hiroyuki Oka, Seiya Jingushi, Toshihiro Izumi, Masao Fukunaga, Katsumi Sato, Kozo Nakamura
3:30 PM
Paper No. 130
The Efficacy of a Locally Injectable Prostaglandin EP-2 Receptor Agonist on Fracture Healing
Mohit Bhandari, David Thompson, Irina Kaplan, Vishwas Paralkar, Gojko Buljat, David Sanders, John Schwappach, Slobodan Vukicevic
3:45 PM
Paper No. 131
Battle Casualty Survival With Emergency Tourniquet Use
John Kragh, Michelle Littrell, John Jones, Thomas Walters, David Baer, Charles Wade
4:00 PM
Paper No. 132
TGFb3 Expression as a Predictor of Heterotopic Ossification Following Musculoskeletal Trauma
Youngmi Ji, Wesley Jackson, Amber Aragon, Jared Vogler, Rocky Tuan, Leon Nesti
Spotlight Session 29 Implants
Room # 291-292
Moderators: Victor Goldberg, MD and Stuart Barry Goodman, MD, PhD
Spotlight Session 29 Implants
Room: 291-292
2:45 PM
Spotlight Speaker: Kenneth A Mann, PhD, East Syracuse, NY
Micromechanics of Cemented Implant Fixation: How Fixed is Well-Fixed?
3:15 PM
Paper No. 133
Effects of the Mixture of Hydroxyapatite Granules into Bone Chips on the Dynamic Migration of Cemented Acetabular Cups Fixed with Impaction Bone-grafting
Shunji Kishida, Satoshi Iida, Hirotsugu Ohashi, Tomoyuki Yamazawa, Yuji Tanabe
3:30 PM
Paper No. 134
How a mechanobiological model can help to predict the periprosthetic healing of an unstable implant
Pascal Swider, Gaëtan Guérin, Dominique Ambard
3:45 PM
Paper No. 135
Influence of Statins Locally Applied from Orthopaedic Bone Implants on Osseous Integration
Stephan Pauly, David Back, Kathrin Kaeppler, Norbert Haas, Gerhard Schmidmaier, Britt Wildemann
4:00 PM
Paper No. 136
Preoperative Muscle Activation Patterns Affect Implant Migration
David Wilson, Cheryl Hubley-Kozey, Michael Dunbar, Janie Astephen Wilson
Spotlight Spotlight Session 30 Bone Adiposity
Room: 293-296
2:45 PM
Spotlight Speaker: Clifford Rosen, MD, Bangor, ME
Bone Marrow Adiposity; Structural and Functional Correlates
3:15 PM
Paper No. 137
Bone Marrow Adiposity Increases in Caloric Restricted Mice
Douglas Adams, Elizabeth Gardner, Vilmaris Diaz-Doran, Renata Rydzik, Jenifer Fenton
3:30 PM
Paper No. 138
Survival and functionality of MSCs depend on an appropriate supply of glucose to overcome an episode of long-term severe continuous hypoxia
Mickael Deschepper, Hervé Petite, Morad Bensidhoum, Katim Oudina, Bertrand David
3:45 PM
Paper No. 139
The transcriptional Regulation of STAT5A and STAT5B in Adipogenesis
Ho Sun Jung, Jae Woo Kim, Jin Woo Lee
4:00 PM
Paper No. 140
Adiponectin increases BMP-2 expression in osteoblasts via AdipoR receptor signaling pathway
Chun-Yin Huang, Hsiao-Chi Tsai