Workshops / Symposia
| Sunday, March 7 8:00 AM - 9:30 AM |
Workshop 1 Room: Auditorium A Download PDF Handout
Biomechanics and Inflammation in Health and Diseases of Musculoskeletal System: Anti-Inflammatory Component of Mechanosignaling
Organizers: Christopher T Chen, PhD, New York, NY and Christopher H Evans, PhD, Boston, MA
Anti-Inflammatory Effects of Exercise and Consequences of Physical Inactivity
Bente K Pedersen, MD DMSc, Copenhagen, Denmark
Mechanical Signals Cartilage and Chondrocytes
David A Lee, PhD, London, UK
Molecular Basis of Exercise: Studies on Gene Regulation in Osteoarthritis
Sudha Agarwal, PhD, Columbus, OH
Workshop 2 Room: Auditorium B Download PDF Handout
Adaptation in Articular Cartilage - Evidence, Assessment and Interpretation
Organizers: Mark Hurtig, DVM, Guelph, ON, Canada and Stephen Waldman, PhD, Kingston, ON, Canada
The development of enhanced biomechanical and biochemical cartilage properties during development are well established; however, the evidence for a long-term adaptive response in adult articular cartilage is not as clear. Is osteoarthritis merely a winding down of a highly ordered tissue that has a limited repertoire of responses? Most reports of long-term exercise in animals show that a remodeling response is triggered but a coupled anabolic phase is more difficult to identify. This workshop will discuss the interpretation of biomechanical, biochemical and cellular changes in articular cartilage in response to mechanical stimuli and attempt to identify criteria for assessment of adaptation to changing loading histories.
Mixed Evidence for a Persistent Anabolic Response to Prolonged Exercise
Jukka Jurvelin, Kuopio, Finland
Cartilage Adaptation-Evidence from Human Imaging Studies
Felix Eckstein, MD, Salzburg, Austria
Adult Articular Cartilage-Adaptation-Lessons from Animal Modeling and Naturally Occurring Disease
Mark Hurtig, DVM, Guelph, ON, Canada
Workshop 3 Room: Auditorium C Download PDF Handout
Evaluation and Manipulation of Angiogenesis in Bone Regeneration
Organizers: Kurt D Hankenson, DVM, PhD, Philadelphia, PA and Shawn R Gilbert, MD, Birmingham, AL
Bone is unique among adult tissues in its ability to fully regenerate; however, there is a significant clinical need to accelerate healing, and to promote healing in cases of delayed or non-union. Increasingly, experimental investigations have focused on the critical nature of the robust blood supply to bone for healing. Angiogenesis provides nutrients, egress for degradation products, ingress for inflammatory cells and progenitor cells, and maintains the oxemic status of regenerating bone by delivering oxygen. The purpose of this workshop is to discuss tools for evaluating vascularity during bone healing; to show examples of how the tools are applied in models of bone regeneration; and to demonstrate genetic, pharmacologic, and surgical manipulations to alter vascularity in bone.
Angiogenesis in Normal and Impaired Fracture Healing
Ralph Marcucio, PhD, San Francisco, CA
Methods for Evaluating Vascularization within Regenerating Bone
Robert E Guldberg, PhD, Atlanta, GA
Targeting the HIF-1 Pathway for Bone Regeneration
Thomas L Clemens, PhD, Birmingham, AL
Workshop 4 Room: 291-292 Download PDF Handout Pt1 Download PDF Handout Pt2
Download PDF Handout Pt3 Download PDF Handout Pt4
Protecting and Marketing Your Ideas: Intellectual Property Considerations
Organizer: Gloria L Matthews, DVM, PhD, Framingham, MA
(Presented by the ORS Corporate Affairs Committee)
Promising concepts that begin in the laboratory or clinic depend on establishment of intellectual property for marketability, but a great deal of myth and mystery surrounds this complex topic. In this workshop, a representative of the US Patent and Trademark Office will review the patent application process, patent terminology, what can and cannot be patented, resources available for patent submission, and the decision process including who is involved, how decisions are made, how “prior art” is defined and identified, and timelines for review and notification. Legal aspects of patent filing and maintenance will also be covered by an intellectual property attorney, including types of patents, the concept of “freedom to operate”, rights and obligations conferred by patents, uses of patents (licensing, royalties) as well as average costs for filing, maintenance, and defense of intellectual property. Rounding out the session will be an overview by an academic thought leader with multiple patents of some of the practical considerations for academic based professionals initiating and being inventors on patents.
The Patent Process: From Application to Decision
John Calvert, Alexandria, VA
Legal Aspects of Patent Filing and Ownership
Todd Dawson, Warsaw, IN
Practical Considerations for Academic Based Patents
Glenn Prestwich, PhD, Salt Lake City, UT
| Monday, March 8 8:00 AM - 9:30 AM |
New Horizon Workshops
As well as the established workshops that are meant to have an educational basis, providing an introduction to an established area of research, the ORS has added workshops that highlight new areas of research, new techniques or work that challenges existing dogma. Two New Horizon workshops are being offered on Monday morning.
Workshop 5 Room: Auditorium A Download PDF Handout
Chondrocyte Motility in Development and Disease
Organizer: Charles W Archer, PhD, Cardiff, Wales, UK
Cell migration is a central process in growth, development and maintenance of multicellular organisms. Whilst chondrocytes in articular cartilage appear immobile and fixed in space, this belies the degree of cellular movement required during earlier phases of growth, the subtle cellular movements that occur in mature cartilage and the gross movement of cells that are hallmarks of diseased cartilage. Understanding the nature of chondrocyte motility and application of that knowledge will be key to advancing the current paradigms in tissue engineering and repair of articular cartilage.
Cellular Movement within Cartilage
Teresa I Morales, PhD, Boston, MA
Multiphotonic Microscopy of the Surface of Articular Cartilage
Wan B Kouri, Mexico DF, Mexico
The Role of Migratory Stem Cells in Osteoarthritis
Nicolai Miosge, Goettingen, Germany
Workshop 6 Room: Auditorium B Download PDF Handout
Imaging Stem Cell Fate and Function
Organizers: Dan Gazit, PhD, DMD, Los Angeles, CA and Edward M Schwarz, PhD, Rochester, NY
Stem cells hold tremendous potential for the development of new therapeutic strategies for tissue regeneration. However much has to be learned of the fate and function of these cells in the living tissue. Advanced molecular and micro imaging methods play an increasingly important role in the rigorous evaluation of stem cell-based tissue regenerative strategies. Imaging techniques such as high-resolution micro-Computed Tomography (micro-CT), Single Photon Emission Computed Tomography (SPECT), Positron Emission Tomography (PET), Bioluminescence and Fluorescence imaging provide non-invasive, real-time, quantitative tools for cell and tissue analysis. We are now able to track implanted cells, monitor their differentiation and observe tissue development in vivo. In this workshop, we will review the aforementioned imaging techniques and their application in stem cells- based skeletal tissue regeneration.
High Performance Nuclear Imaging in Regenerative Medicine
Douglas J Wagenaar, Northridge, CA
Imaging as a Window into Stem Cell Biology
Christopher H. Contag, Stanford, CA
Functional Imaging for Skeletal Stem Cell Based Tissue engineering
Dan Gazit, PhD, DMD, Los Angeles, CA
| Tuesday, March 9 8:00 AM - 9:30 AM |
Workshop 7 Room: Auditorium A Download PDF Handout
Hypersensitivity and Biomaterials: What are the Facts, Myths and Legends?
Organizers: A Seth Greenwald, DPhil (Oxon), Cleveland, OH, Lynne C Jones, PhD, Baltimore, MD, and Warren O Haggard, PhD, Memphis, TN
The use of biomaterials in orthopaedics and for repair and regenerative purposes continues to expand with our active and aging populations. Past clinical studies have reported hypersensitivity to some forms of these implanted biomaterials and current studies regarding metal-on-metal total hip joint replacements has renewed debate on this topic. More advanced research tools are presenting improved understandings about the material, tissue, and biological interactions and effects and non-typical effects such as hypersensitivity. The aims of this workshop are to summarize the current facts and understandings and highlight unanswered questions and technical hurdles in this field of hypersensitivity and other biological responses to biomaterials.
Bearing Surfaces for Joint Replacement: New Materials or New Problems!
Stuart B Goodman, MD, PhD, Stanford, CA
David W Murray, MD, FRCS, Oxford, UK
What the heck is ALVAL?
Patricia A Campbell, PhD, Los Angeles, CA
Benign Responses to Orthopaedic Implants: Really?
Joshua J Jacobs, MD, Chicago, IL
Workshop 8 Room: Auditorium B Download PDF Handout
The Armed Forces Institute of Regenerative Medicine: Its Structure, Operations, and Goals
Organizers: Michael J. Yaszemski, MD, PhD, Rochester, MN and George F Muschler, MD, Cleveland, OH
The Armed Forces Institute of Regenerative Medicine (AFIRM) is a translational research consortium whose charge is to bring novel treatments for our injured service men and women to first human use. There are over 100 principal investigators at more than thirty institutions who focus on five areas of investigation: composite tissue transplantation, burn treatment, the treatment of compartment syndrome and its sequelae, scarless healing, and craniofacial reconstruction. The AFIRM is a Department of Defense funded program that encourages collaboration among its members. This emphasis on teamwork, with a common goal of improving trauma and reconstructive care to our war wounded, has fostered synergy, collaborative projects, and convergence to best practices among the AFIRM members. This enthusiasm will hopefully result in better care for not only our injured service members, but also our civilian population.
AFIRM History and Organization: Nerve Regeneration Strategies
Michael J. Yaszemski, MD, PhD, Rochester, MN
Translational Bone Regeneration Strategies
George F Muschler, MD, Cleveland, OH
The Center for the Intrepid: Rehabilitation of our War Wounded and Transition Back to Either Active Duty or Civilian Life
Col James R Ficke, MD, Sam Houston, TX
Workshop 9 Room: Auditorium C Download PDF Handout
Functional Attachment of Soft Tissues to Bone: Development, Healing, and Tissue Engineering
Organizers: Stavros Thomopoulos, PhD, St. Louis, MO and Louis J Soslowsky, PhD, Philadelphia, PA
The attachment of distinct tissue types is a major challenge because of the high levels of localized stress that develop at such interfaces. An effective biologic solution to this problem can be seen at the enthesis, i.e., at the attachment of tendon or ligament (compliant, structural “soft tissues”) to bone (a stiff, structural “hard tissue”). The unique transitional tissue that exists between uninjured tendon/ligament and bone is not recreated during healing, so surgical reattachment of these two dissimilar biologic materials often fails (e.g., the incidence of recurrent tears after rotator cuff repair may be as high as 94%). Recent work has shown that: 1) the enthesis is a functionally graded material with regard to its composition, structure, and mechanical properties, 2) mechanical loading is necessary for the maturation of the enthesis and for tendon/ligament-to-bone healing, 3) inflammation plays a critical role in tendon/ligament-to-bone healing, and 4) tissue engineering solutions will require multi-phased scaffolds as well as controlled cellular interactions to enhance interface healing. Taken together, these results provide guidance and a theoretical framework for ongoing efforts to apply tissue engineering strategies to improve healing and surgical repair of tendon/ligament-to-bone insertions, as well as the formation of complex musculoskeletal tissues and organ systems.
Structure, Function, and Development of Soft Tissue-to-Bone Attachments
Stavros Thomopoulos, PhD, St. Louis, MO
Healing of Soft Tissue to Bone: Lessons from the Knee and the Shoulder
Scott A Rodeo, MD, New York, NY
Interface Tissue Engineering for Integrative Soft Tissue Healing
Helen Lu, PhD, New York, NY
Post-Traumatic Osteoarthritis: Improved Understanding and Opportunities for Early Intervention
Organizers: Donald D. Anderson, PhD, Iowa City, IA and Joseph A. Buckwalter, MS, MD, Iowa City, IA
Osteoarthritis (OA) is the most common joint disease, and it is among the most important causes of pain, disability and economic loss in all populations. The physical impairment caused by OA of a single lower extremity joint is equivalent to that reported for major life-altering disorders such as end-stage kidney disease and heart failure. The causes of OA are not well understood, but a substantial fraction (~12%) of the overall burden of disease of OA arises secondary to joint trauma. With the best current care of significant joint injuries, the risk of post-traumatic OA ranges from about 20% to more than 50%; and despite the evolution of surgical interventions for the treatment of joint injuries, this risk has not decreased appreciably in the last 20 years. Thus, there is compelling need for more effective approaches to treating patients with joint injuries, ideally with methods that have minimal risk of complications. The central theme of this workshop is that acute-impact joint injuries initiate a sequence of events that cause the progressive joint degeneration that leads to post-traumatic OA, and that new treatments of acute joint injury can mitigate or arrest these adverse events, and thus promote joint healing.
Incidence, Impact, and Potential for Prevention of Post-Traumatic OA
Joseph A. Buckwalter, MS, MD, Iowa City, IA
Joint Trauma and its Acute and Chronic Sequelae
Farshid Guilak, PhD, Durham, NC
Early Biologic Intervention Targets for Preventing Post-Traumatic Joint Degeneration
Susanna G Chubinskaya, PhD, Chicago, IL
Paperless Workshop Handouts ORS will have a limited number of stations to print handouts on-site. To avoid lines, we encourage you to make your selections in advance before arriving in New Orleans. |
| Tuesday, March 9 1:00 PM - 2:30 PM |
ORS/AAOS Symposium I Room: Auditorium B
Intramuscular Fatty Atrophy: Physiology, Imaging, and Treatment
Moderator: Richard L Lieber, PhD, La Jolla, CA
Intramuscular fatty deposition represents a severe clinical problem. This symposium will review the clinical approach to treating fatty deposition, the physiology fat deposition, and methods for imaging fat.
Objectives of the symposium:
- Review basic fat metabolic pathways in skeletal muscle
- Learn presentation of fatty atrophy in rotator cuff tears and lumbar spine pathology
- Learn three different methods for noninvasive imaging of fat in human skeletal muscle
Welcome and Introduction
Richard L Lieber, PhD, La Jolla, CA
Biology of Intramuscular Fat Deposition
Simon Schenk, Ph.D, La Jolla, CA
Discussion
Noninvasive Imaging of Fat in Human Skeletal Muscle
Samuel R. Ward, PhD, La Jolla, CA
Discussion
Clinical Approach to Treating Muscle Fatty Atrophy
Christian Gerber, MD, Zurich, Switzerland
Discussion
| 2:45 PM - 4:15 PM |
ORS/AAOS Symposium II Room: Auditorium B
Applied Biomechanical Engineering – Joint Injuries from Benchtop to Bedside
Moderators: Thomas D Brown, PhD, Iowa City, IA and Steven A Olson, MD, Durham, NC
The Symposium seeks to bridge the spectrum of biomechanics from basic science to clinical application by focusing on the topic of articular injury, with emphasis on the response to injury and the development of post traumatic arthritis. Dr. Brown will focus on macromechanics of articular injury with emphasis on the role of computational modeling of both living and cadaveric materials. Dr. Athanasiou will discuss applied mechanics at a tissue level to live constructs with emphasis on biologic response to mechanical loading. Dr. Olson will discuss applied mechanics in the context of an in-vivo model in which loading is applied to create an articular fracture in a survival animal model. The emphasis will focus on the translation of mechanics into biologic response to injury. Finally Dr. Dirschl will discuss aspects of mechanics for the clinician to consider for incorporation into practice now, as well as gaps that remain to allow further translation of science of articular injuries into clinical practice.
Computational Modeling in Joint Injury
Thomas D Brown, PhD, Iowa City, IA
Micromechanics of Injury
Kyriacos A Athanasiou, PhD, Houston, TX
Articular Mechanics and Biology
Steven A Olson, MD, Durham, NC
Incorporation of Data into Clinical Practice: What is Useful Now and What Gaps Remain?
Douglas R Dirschl, MD, Chapel Hill, NC