Christopher Mendias, PhD, Hospital for Special Surgery
Gretchen Meyer, PhD, Washington University
The purpose of this workshop is to introduce scientists to common techniques used to study skeletal muscle growth and regeneration. The workshop will cover mouse models of muscle hypertrophy and injury, molecular genetics tools used to study different populations of cells in muscle tissue, and in vitro techniques to study muscle stem cells. There will be a didactic portion, with ample time for an interactive discussion and questions at the end of the workshop.
In Vivo Models of Myogenesis Esther Dupont-Versteegden, PhD, University of Kentucky
Myogenesis in a Dish: Advantages and Limitations to Myogenic Cell Culture Gretchen Meyer, PhD, Washington University
ORS Industry Engagement Committee (IEC)
ORS Spine Section
Sally LiArno, PhD, Stryker Orthopaedics
Saeed Khayatzadeh, PhD, Edward Hines Jr. VA Hospital
Patient-Reported-Outcome-Measures (PROMs) or Patient-Reported-Outcomes (PRO) assess the quality of care delivered to patients from the patient perspective. PRO questionnaires can be used to assess many factors including symptoms, functioning, health status, general health perceptions, quality of life, and activity level. This workshop focuses on how PROMs calculate the health gains after orthopaedic surgical treatment using pre- and post-operative surveys.
The Last Night of the PROMs? Should We Still Be Evaluating Surgical Outcomes With Patient Level Metrics David Hamilton, PhD, BSc (hons), BSc (hons), MCSP, University of Edinburgh
Are Sensors the Holy Grail of PROs? What Digital Technology Will Mean for Quality Measures Stefano Bini, MD, University of California San Francisco
In Search of Biomarkers Predictive of PROs in Spinal Degeneration and Back Pain Nadeen Chanine, PhD, Columbia University
Nancy Pleshko, PhD, Temple University
Susan Bukata, MD, University of California Los Angeles
Dr. Adele Boskey made major contributions to the fields of bone biology and mineralization using novel in vitro systems, and she expanded on these studies throughout her career. Her research sought to understand the composition of mineral and matrix in osteoporosis, osteogenesis imperfecta, and other diseases of bone fragility, and the effect of therapeutics on bone, at multiple structural levels in preclinical models and clinical tissues. This workshop will address the molecular basis of biomineralization, followed by discussion of how factors important in skeletal mineralization affect bone biomechanics, diseases associated with poor quality mineral and matrix, and current therapeutics to improve mineral quality. Together, this workshop will facilitate an exchange of knowledge and stimulate discussion among renowned keynote speakers, scientists and clinicians at all career levels with an interest in bone mineralization and quality, while honoring the memory and contributions of one of our most important leaders in the field of orthopaedic research.
The Evolving Role of Matrix Vesicles in the Regulation of Musculoskeletal Tissues Barbara D. Boyan, PhD, Virginia Commonwealth University
Skeletal Mineralization and Bone Mechanical Properties Marjolein C.H. van der Meulen, PhD, Cornell University
Insights Into A Rare Bone Disease: Osteogenesis Imperfecta, From Bench to Bedside and Back Again Cathleen L. Raggio, MD, Hospital for Special Surgery
Canadian Orthopedic Research Society
Fackson Mwale, PhD, McGill University
Albert Yee, MD, MSc, FRCSC, Sunnybrook & Women’s College
Joint replacement remains one of the most successful interventions in orthopaedic surgery however there are still patients who do not achieve their maximum function due to instability and/or persistent pain. This symposium will review current evidence linking patient reported outcomes and functional analysis as well as current evidence on how surgical approach and prosthetic influence impacts patient function. Finally, advanced modeling combining finite element analysis and patient specific data in the understanding the pathomechanism of joint degeneration will be presented.
How to Interpret Biomechanical/Functional Analysis of the Lower Extremity? Mario Lamontagne PhD, University of Ottawa
Gait Analysis after Total Hip Replacement: What is the Influence of Surgical Approach and Implant Design? Paul E. Beaulé MD, University of Ottawa
Gait Analysis After Total Knee Replacement: Implant Design or Kinematic Reconstruction Which is More Important? Janie Wilson, PhD, Dalhousie University
Advanced Modeling/Imaging Using Patient Specific Data the Next Frontier in Arthritis Prevention David R. Wilson, PhD, University of British Columbia
Christopher P. Roche, MSE, MBA, Exactech, Inc.
Dennis Janssen, PhD, Radboud University Medical Center
Total joint arthroplasty is one of the most cost-effective and clinically successful medical procedures ever devised, with highly predictable outcomes for many different indications. This workshop provides a historical overview of prosthesis designs in the hip, knee, and shoulder, describing how devices for each application have evolved to: 1) improve long-term survivorship, 2) enhance patient satisfaction, 3) reduce the occurrence and severity of complications, 4) address expanding usage, new indications and surgical techniques, and 5) utilize novel materials and manufacturing technologies. An improved understanding of each prosthesis design lineage, better informs clinicians, designers, and medical researchers of modern design requirements in order to create new innovations that optimize function and offer the potential for improved outcomes.
Historical Overview of Shoulder Arthroplasty Prosthesis Design Evan Flatow, MD, Mt. Sinai School of Medicine
Historical Overview of Hip Arthroplasty Prosthesis Design John Callaghan, MD, University of Iowa
Historical Overview of Knee Arthroplasty Prosthesis Design Michael Mont, MD, Cleveland Clinic
Participants in this workshop will gain an in-depth understanding of how regenerative medicine research focuses on the repair or replacement of tissues lost to injury, disease, or age, primarily via the enhancement of endogenous stem cell function or the transplantation of exogenous stem cells; whereas rehabilitation science emphasizes the use of mechanical and other physical stimuli to promote functional recovery. Learn how rehabilitation and regenerative medicine research are being integrated in order to create synergy for maximizing orthopaedic treatment outcomes. Identifying the underlying mechanisms of this synergy allows for improved rehabilitation protocols based on empirical data, and the use of appropriate timing and the right approaches of rehabilitation interventions will help to optimize and improve outcomes for the growing regenerative medicine patient population. Understanding and implementing findings from these two approaches will inform orthopaedic practice as these innovative technologies make their way to the clinic.
Regenerative Rehabilitation: Background and Introduction Christopher Evans, PhD, Mayo Clinic
Stimulation of Bone Healing Through Mechanical Loading Vaida Glatt, PhD, University of Texas Health Science Center at San Antonio
Chondrogenesis in Response to Mechanical Load for Cartilage Repair Martin Stoddart, PhD, FRSB, AO Research Institution
Mark Ehrensberger, PhD, University of Buffalo
Sujee Jeyapalina, PhD, University of Utah
Osseointegrated (OI) prosthetic limbs represent a promising alternative to conventional socket prostheses. The OI prostheses are directly anchored within the bone of the residual limb and utilize a percutaneous connection to the external artificial limb. Currently, there are three types of OI prostheses under clinical trial in the USA. Success of these trials will enable a wider use of this technology within the US health care system. In this workshop, experienced clinician scientists will introduce the general concepts of OI prostheses, summarize recent clinical experiences and highlight future research directions. This overview will give both orthopedic researchers and clinicians a “bench to bedside” account of these unique devices, which can perhaps revolutionize amputee care worldwide.
Experience with the OPRA System Rickard Brånemark, MD, PhD, University of California San Francisco
Transfemoral Osseointegrated Prosthesis – Utah Implant Design Principles, Translational Research and Clinical Outcomes James P. Beck, MD, University of Utah
The Department of Defense Osseointegration Program Jonathan Forsberg, MD, PhD, USU-Walter Reed
Musculoskeletal Tumor Society (MSTS)
Francis Y. Lee, MD, PhD, Yale University
Michelle Ghert, MD, McMaster University
In the era of Personalized Medicine and Post-Genome Sequencing, genetic profiling and molecular signaling data are readily available for human pathology samples. And yet, such big data are not readily utilized to treat altered bone properties and tumorigenesis. This workshop will highlight molecular signaling that distinguishes normal and neoplastic osteogenesis and stemness in order to discover new therapeutic opportunities to enhance bone health and cancer outcomes.
Normal Osteogenic Differentiation and Stemness Hicham Drissi, PhD, Emory University
Aberrant Signaling in Neoplastic Osteoprogenitors and Therapeutic Targets Bang Hoang, MD, Albert Einstein School of Medicine
Aberrant Stemness of Neoplastic Osteoprogenitors and Therpaeutic Targets Parker Gibbs, MD, PhD, University of Florida
Orthopedic patients with limb injuries secondary to trauma or disease can benefit from novel therapeutic approaches to address tissue injury or amputation. While humans have negligible innate composite tissue regeneration in limbs following injury, some non-human vertebrates have highly regenerative limbs/appendages. Basic research focused on regeneration in these species will lead to a molecular understanding of innate tissue renewal in vertebrates, and can ultimately be leveraged into translational research efforts. This workshop will introduce three model organisms currently used to gain a mechanistic understanding of limb/appendage regeneration in vertebrates.
Blastema Physiology and Induced Skeletal Regeneration in Mammals Ken Muneoka, PhD, Texas A&M University
Lizard Tail Regeneration as an Instructive Model of Enhanced Healing Capabilities in an Adult Amniote Thomas Lozito, PhD, University of Pittsburgh
Identifying Transcriptional Networks Associated with Appendage Regeneration Randal Voss, PhD, University of Kentucky
Karen L. Troy, PhD, Worcester Polytechnic Institute
Darryl D. D’Lima, PhD, Scripps Clinic
It is not possible to directly and non-invasively measure the actual forces, stresses, and strains that are transmitted through bones and joints. Yet, design of orthopaedic implants, engineered tissue constructs, and interventions to promote healthy tissue adaptation all depend upon this knowledge. This workshop will feature three presenters who have made significant advances in measuring joint and tissue loading in healthy and clinical populations. Experimental techniques, limitations, and areas of opportunity will be identified and discussed.
Computational Modeling Approaches to Estimate In Vivo Bone Strain Karen L. Troy, PhD, Worcester Polytechnic Institute
In Vivo Measurement of Knee Joint Contact Forces Darryl D. D’Lima, PhD, Scripps Clinic
In Vivo Computational Prediction of Knee Joint Contact Forces
BJ Fregly, PhD, Rice University
A Practical Guide for Performing Human In Vivo Bone Strain Measurements
Pediatric Orthopaedic Society of North America (POSNA)
Roger Cornwall, MD, Cincinnati Children’s Hospital
Brian Snyder, MD, PhD, Boston Children’s Hospital
Pediatric neuromuscular disorders include a heterogeneous array of severely disabling conditions for which multiple opportunities exist for truly game-changing innovation. Historically, virtually all pediatric neuromuscular disorders have been approached with similar simplistic orthopedic strategies: stretch or cut muscles that are tight, cut the bones if cutting the muscles doesn’t work, brace muscles that are weak, and resort to a wheelchair when braces don’t work. However, recent research, is leading to new disorder-specific therapies which address underlying biological and biomechanical mechanisms and proactively mitigate deforming forces on the developing skeleton. This workshop will highlight these advances and opportunities in presentations and discussions led by clinician-scientists and clinician-engineers who both actively research and actively treat pediatric neuromuscular disorders. Participants from diverse backgrounds (science, engineering, medicine, surgery, industry) will be able to identify novel collaborations, hypotheses, and development opportunities in this wide-open field of musculoskeletal research.
Pediatric Neuromuscular Disorders: How Can Biology and Engineering Help Alleviate the Burden of Disease? Brian Snyder, MD, PhD, Boston Children’s Hospital
Success Stories: Game Changers in Spinal Muscular Atrophy and Duchenne’s Muscular Dystrophy Benjamin Alman, MD, Duke University
Shifting the Paradigm of Neuromuscular Contractures: Lessons from Neonatal Brachial Plexus Injury Roger Cornwall, MD, Cincinnati Children’s Hospital
Cerebral Palsy: incorporating new techniques and technology into a physiological paradigm James McCarthy, MD, Cincinnati Children’s Hospital
Douglas E. Padgett, MD, Hospital for Special Surgery
Timothy M. Wright, PhD, Hospital for Special Surgery
While the success and longevity of joint replacement is well documented, implant failure can and does occur. The introduction of some newer designs and bearings over the past decade have unfortunately resulted in the need for early revision. Many of these failures were biologically driven and were not recognized clinically. This workshop will focus on the clinical presentations of some of these failures, the role of enhanced imaging techniques such as MRI to assess the array biologic responses observed and finally discuss the role that implant retrieval analysis can play in understanding some of the mechanisms by which these phenomena occur.
The Clinical Evaluation and Workup of the Failed Implant Mathias P.G. Bostrom, MD, Hospital for Special Surgery
The Use of MR in Evaluating the Failed Implant Hollis G. Potter, MD, Hospital for Special Surgery
The Role of Implant Retrieval in Evaluating Failed Implants Timothy M. Wright, PhD, Hospital for Special Surgery
Bettina M. Willie, PhD, McGill University and Shriners Hospital for Children
X. Sherry Liu, PhD, University of Pennsylvania
Micro computed tomography imaging enables unprecedented 3D visualization of tissue microstructure non-destructively, and has thereby emerged as a gold standard method to assess bone structure, geometry, and microarchitecture. An important advance in MicroCT technology in recent years is in vivo imaging of small animals. This imaging strategy not only minimizes the number of animals required while enhancing statistical power, but also provides new insight into musculoskeletal disease, injury, and repair processes through an added temporal dimension. Moreover, a recent implementation of MicroCT technology in clinical applications, namely high-resolution peripheral quantitative CT (HR-pQCT), enables longitudinal assessment of skeletal alterations at microscale of humans. The aim of the workshop is to bring together scientists and clinicians to discuss current imaging protocols and image processing methodology related to longitudinal MicroCT imaging in preclinical and clinical studies.
Preclinical Longitudinal MicroCT Imaging Ralph Müller, PhD, ETH Zurich
Clinical In Vivo MicroCT Imaging Steven Boyd, PhD, University of Calgary
Biomechanical In Vivo MicroCT Imaging Enrico Dall’Ara, PhD, University of Sheffield
Johnny Huard, PhD, The University of Texas Health Science Center at Houston
Aging is arguably the most important, yet poorly understood aspect of biology. There is compelling evidence to support the hypothesis that the underlying cause of aging is the cell autonomous, time-dependent accumulation of stochastic damage to cells, organelles, and macromolecules. It is also clear from parabiosis, serum transfer, and cell ablation studies that cell non-autonomous mechanisms play important roles in driving degenerative changes that arise as the consequence of spontaneous, stochastic damage. However, the relative contribution of cell autonomous and non-autonomous mechanisms to systemic aging in different organisms is unclear. The goal of this workshop is to educate and inform participants that the process of aging specific cell and/or tissue types has effects on not only neighboring cells, but also on the rate of systemic aging. The major goal will be to identify drugs or agents to target critical pathways that drive aging in these specific types of cells or tissues, which may result in therapeutic approaches to extend healthy aging as well as delay aging-related disorders, such as osteoathritis (OA).
Identification and Characterization of Key Cell and Tissue Types That Contribute to Driving Systemic Aging Laura Niedernhofer, MD, PhD, The Scripps Research Institute
Identification of Key Cell Autonomous and Non-Autonomous Signaling Mechanisms Involved in Driving Systemic and Local Aging Paul Robbins, PhD, The Scripps Research Institute
Effect of Tissue and Cell Type-Specific Aging on Stem Cell and Stem Cell Niche Function Johnny Huard, PhD, The University of Texas Health Science Center at Houston
Dominik Haudenschild, PhD University of California Davis
Blaine Christiansen, PhD, University of California Davis
Joint injuries initiate changes in joint tissue homeostasis that often culminate in osteoarthritis. A focus of current research is to mechanistically connect the initial injury event, and the eventual osteoarthritis. This workshop will highlight advances in identifying the acute injury-responses in different joint tissues, with a focus on the early responses that determine the trajectory of disease progression. This workshop will bring together the unique perspectives of the presenters who have each approached the identification of early OA differently in their research. The goal is to establish a more comprehensive understanding of the interplay between early post-injury changes in gene expression, cartilage repair and remodeling, and the generation of biomarker “profiles” in the injured joint. An additional focus will be how the early responses can vary across different genetic backgrounds.
Injury-Induced Changes in Transcription During the Acute Phase Gabriela Loots, PhD, Lawrence Livermore National Laboratories
Genetic Variation Affects Transcriptional Responses to Joint Injury Farooq M. Rai, PhD, Washington University
Mechanical Interplay Across the Osteochondral Junction Andrew Pitsillides, BSc(Hons) PhD, Royal Veterinary College University of London
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