(Evan Buettman, Christopher D. Kegelman, Jiun Chiun Chang, Jeffery J. Nielsen, Meghan Moran, Melanie Haffner-Luntzer, Robert L. Zondervan)
Junior Investigator 3-Minute Thesis Competition with support from Bioventis
Targeting Neuropeptides to Bone Fractures for Accelerated Healing
Jeffery J. Nielsen, Stewart A. Low, Nicholas A. Young, Neal T. Ramseier, Rahul V. Hadap, Philip S. Low
Purdue University
Podium Student/Trainee
YAP and TAZ Mediate Osteocyte Perilacunar/canalicular Remodeling
Christopher D. Kegelman, Jennifer C. Coulombe, Kelsey M. Jordan, Daniel J. Horan, Alexander G. Robling, Virginia L. Ferguson, Teresita M. Bellido, Joel D. Boerckel
University of Pennsylvania
Podium Faculty
Chronic Psychosocial Stress Disturbs the Inflammatory Response and Endochondral Ossification After Bone Fracture Via β-adrenoceptor Signaling
Melanie Haffner-Luntzer, Sandra Foertsch, Verena Fischer, Katja Prystaz, Miriam Tschaffon, Yvonne Moedinger, Anita Ignatius, Stefan O. Reber
Department of Orthopaedic Research and Biomechanics, Ulm University
Poster
Disruption of CD47 Signaling Promotes Endothelial Cell Proliferation but Inhibits Mesenchymal Stem Cell Expansion Leading to Delayed Fracture Healing
Robert L. Zondervan, John D. Reicha, Daniel R. Jenkins, Sloane A. Brazina, Jaimo Ahn, Ralph S. Marchcio, Jeffery S. Isenberg, Kurt D. Hankenson
University of Michigan
LIF Enhances Callus Formation During Fracture Healing
Jiun Chiun Chang, Diane Hu, Tiffany Shao, Brandon Gaston, Theodore Miclau, Ralph Marcucio, Chelsea S. Bahney
University of California, San Francisco
(Daniela Warnecke, Su-Jin Heo, Amy McNulty, Lutz Dürselen, Chathuraka T. Jayasuriya)
Podium
Dynamic Movements Considerably Increase Strains and Forces in the Meniscus and its Meniscal Attachments
Lutz Dürselen, Florian Schall, Steffen Hacker, Stefan van Drongelen, Andreas Seitz, Anita Ignatius
Institute of Orthopedic Research and Biomechanics
Poster
Nuclear Softening Promotes Interstitial Cell Migration to Enhance Repair of the Knee Meniscus
Su-Jin Heo, Ana Peredo, Sarah Gullbrand, Elizabeth Henning, Kwang Hoon Song, Dong Hwa Kim, Jason Burdick, Robert Mauck
University of Pennsylvania
Fiction Testing Under Gait Conditions Reduces Friction of Meniscus Against Cartilage
Daniela Warnecke, Luisa de Roy, Anita Ignatius, Lutz Dürselen
Institute of Orthopaedic Research and Biomechanics
Cartilage-derived Chondroprogenitors Require CXCR4 Activation To Successfully Bridge Meniscal Fibrocartilage Tears
Chathuraka T. Jayasuriya, Salomi Desai, John Twomey-Kozak, Jake Newberry, Brett D. Owens, Michael G. Ehrlich
Rhode Island Hospital/Brown University
(Kartik Mangudi Varadarajan, Jonathan Jeffers)
Podium
Non-invasive Diagnosis of Aseptic Implant Loosening via Electrical Impedance Tomography
Kartik Mangudi Varadarajan, Tyler N. Tallman, Anastasios John Hart
Massachusetts General Hospital
Poster
Clinical and Biomechanical Cluster Classification Before TKA Impacts Functional Outcome
Kathryn L. Young-Shand, Patrice C. Roy, Syed S. R. Abidi, Michael J. Dunbar, Janie L. Astephen Wilson
Dalhousie University
3R
Organ-on-a-chip System for the Modeling of Synovial Joint Pathologies
Zhong Li, Zixuan Lin, Monica R. Lopez, Benjamen O’Donnell, Xinyu Li, Ian J. Moran, Peter G. Alexander, Stuart B. Goodman, Bruce A. Bunnell, Hang Lin, Rocky S. Tuan
University of Pittsburgh
Podium
NELL-1-based Systemic Therapy Prevents Long-duration Spaceflight-induced Osteoporosis in Rodents
Jin Hee Kwak, Jiayu Shi, Pin Ha, Hsin Chuan Pan, Yulong Zhang, Eric Chen, Louis Stodieck, Jong Kil Kim, Xinli Zhang, Benjamin Wu, Kang Ting, Chia Soo
University of California Los Angeles
Poster
Effect of High Fat Diet on the Fracture Resistance of Bone in Non-Diabetic and Diabetic Mice
Amy Creecy, Kara Donovan, Alyssa R. Merkel, Sasidhar Uppuganti, Jeffry S. Nyman
Vanderbilt University
(Tyler J. DiStefano, Sibylle Grad, Divya Krishnamoorthy, Edward D. Bonnevie, Sarah Gullbrand, Grace Mosley)
Podium
The Spatial and Temporal Expression of Canonical and Non-Canonical Wnts in the Maturing Posterolateral Spine Fusion
Steven M. Presciutti, Thanh Doan, Mesfin Teklemariam, Sreedhara Sangadala, Scott Boden, Hicham Drissi
Emory University
Differing Effects of High-fat Diet and the Receptor for Advanced Glycation End Products on Lumbar Vertebrae and Intervertebral Discs in Growing Male and Female Mice
Divya Krishnamoorthy, Danielle N. D’Erminio, Robert C. Hoy, Devorah M. Natelson, Damien M. Laudier, Svenja Illien-Junger, James C. Iatridis
Icahn School of Medicine at Mount Sinai
Sex Differences in the Interaction Between Biomechanical Tissue Properties of Rat Intervertebral Discs and Mechanical Pain Following Annular Puncture Injury
Grace E. Mosley, Phillip Nasser, Alon Lai, Daniel Charen, Thomas W. Evashwick-Rogler, James C. Iatridis
Icahn School of Medicine at Mount Sinai
Poster
Disc Degeneration Alters Endplate Morphology and Mechanics and Reduces Disc Nutrition in a Rabbit Model
Sarah E. Gullbrand, Beth G. Ashinsky, Edward D. Bonnevie, Stephen Pickup, Chao Wang, Lin Han, Robert L. Mauck, Harvey E. Smith
University of Pennsylvania
Fibrosis and Markers of Pain are Upregulated in the Intervertebral Disc Following Prolonged Tungsten Exposure: An in vivo Study
Michael P. Grant, Hsiang Chou, Alicia Bolt, Laura M. Epure, John Antoniou, Koren K. Mann, Fackson Mwale
Lady Davis Institute for Medical Research, McGill University
In Vivo Fluid Convection in Human Intervertebral Discs Varies by Disc Region and Degeneration Grade
John T. Martin, Alexander B. Oldweiler, Adam P. Goode, Louis E. DeFrate
Duke University
Tissue Integration of Acrylate-based Hydrogels Via Multifunctional Chondroitin Sulfate for Annulus Fibrosus Repair
Tyler J. DiStefano, David Goldberg, Steven B. Nicoll, James C. Iatridis
Icahn School of Medicine at Mount Sinai
Alterations in Fibrous Network Topography Regulates Onset of Fibrotic Phenotypes in Annulus Fibrosus Cells
Edward D. Bonnevie, Sarah E. Gullbrand, Beth G. Ashinsky, Tonia K. Tsinman, Dawn M. Elliott, Harvey E. Smith, Robert L. Mauck
University of Pennsylvania
Regulating the Phenotype of Nucleus Pulposus Cells by Laminin-Mimetic Peptide-Coupled Substrates
Marcos N. Barcellona, Xiaoyun Yang, Nia Myrie, Bailey V. Fearing, Michael Talcott, Munish C. Gupta, Michael P. Kelly, Lukas P. Zebala, Jacob M. Buchowski, Lori A. Setton
Washington University in St. Louis
(Angelina D. Schönenberger, Peter Amadio, Catherine A. Bautista, Ryan J. Leiphart)
Podium
Exosome Educated Macrophages Improve Tendon Healing Compared to Exosomes
Connie S. Chamberlain, Anna E.B. Clements, John A. Kink, Ugeun Choi, Jessica D. Pederson, Peiman Hematti, Ray Vanderby
University of Wisconsin-Madison
Identification of a Latent Resident Progenitor Population in the Adult Mouse Tendon
Jenna L. Galloway, Mor Grinstein, Dan Montoro, Jayaraj Rajagopal
Massachuetts General Hospital
Unique Subpopulation of Col1a1CFP Negative Tenocytes that Exhibit MMP Activity
Catherine A. Bautista, Xi Jiang, Nathaniel A. Dyment
University of Pennsylvania
Poster
Mechanical Overload And Matrix Disorganization Cooperate To Initiate Macrophage Polarization And Predispose NfκB Pathway Activation By Paracrine Signaling To Tendon Fibroblasts
Angelina D. Schönenberger, Unai Silvan, Jasmin Egloff, Marita Mauracher, Anna Bird, Jonas Widmer, Katharina Maniura, Sandro F. Fucentese, Jess G. Snedeker
ETH Zurich
Mitochondria Dysfunction In Tenocytes From Human Tendinopathy Patients
Yusuke Nakagawa, Camila Carballo, Ying Zhang, Susumu Wada, Miguel Otero, Michelle L. Delco, Lisa Fortier, Scott Rodeo
Tokyo Medical Dental University
Collagen VI Plays an Important Role in FDL Tendon Mechanics that is Distinct from the Role of Biglycan
Ryan J. Leiphart, Snehal S. Shetye, Hai Pham, Stephanie N. Weiss, Marian F. Young, Louis J. Soslowsky
McKay Orthopedic Research Laboratory, University of Pennsylvania
