RIGs foster the thoughtful exchange of ideas within the global multi-disciplinary community of the ORS by providing the opportunity to engage in informative, transformative, and live discussion with colleagues in a specific area of musculoskeletal research, whether basic, applied, clinical, and/or orthopaedic. To explore content that is complementary or different to the ORS Annual Meeting, RIGs are encouraged to focus on unique approaches, methodologies, diseases, or connections that inspire brainstorming across our multi-disciplinary groups.

*RIG schedule subject to change. 

Saturday, February 8

12:30 PM – 1:15 PM

Organizers:
Yang Xia, PhD, Oakland University
Xiaojuan Li, PhD Lerner Research Institute, Cleveland Clinic

Imaging in the 21st century goes far beyond simple visualizations. Modern imaging uses a wide range of physical principles and technical approaches to probe different aspects of the biological systems at different resolutions. These tools include atomic/electronic/optical microscopes that can identify specific molecules and cells, optical/MRI/CT microscopes that can map tissue characteristics in animal models and ex vivo specimens, and clinical MRI/CT scanners that can detect diseases in humans.

This RIG will feature three speakers to briefly summarize the salient nature of the imaging technologies that can benefit orthopaedic research. Second, a large portion of the session time will be used as the group discussion, among the speakers and the audience, for ways to incorporate novel imaging tools and approaches into orthopaedic research.

Invited Speakers:

Multidisciplinary imaging at microscopic resolutions
Yang Xia, PhD, Oakland University

Advanced methods in ex vivo and in vivo imaging of OA
Xiaojuan Li, PhD Lerner Research Institute, Cleveland Clinic

Values and latest findings in clinical imaging of OA
Hollis Potter, MD, Hospital for Special Surgery

Sunday, February 9

12:15 PM – 1:15 PM

Organizers:
Brian Johnstone, PhD, Oregon Health & Science University
Heather Pidcoke, MD, PhD, Colorado State University

Adaptive designs have been used by major pharmaceutical and device companies to improve the efficiency and ethical balance of randomized clinical trials. Increasingly, academic clinical trialists are also adopting these study design methods for the same purpose, and furthermore, these methods can be adapted for preclinical studies. This RIG will highlight how adaptive designs can be used in preclinical, clinical veterinary, and translational human studies to improve efficiency, minimize cost, reduce patient exposure to risk, and maximize the potential to correctly answer the research question. The RIG will discuss the creation of a musculoskeletal translational research network to promote coordinated preclinical, clinical veterinary and translational human studies using adaptive design techniques.

The first 100 attendees will enjoy a complimentary bagged lunch and beverage! 

Overview of Adaptive Design
Roger Lewis, MD, PhD, Harbor-UCLA

Musculoskeletal Adaptive Design Network
Heather Pidcoke, MD, PhD, Colorado State University

Musculoskeletal Infection RIG 2020

11:15 AM – 12:30 PM

Organizers:
Jacobus J.C. (Chris) Arts, PhD, Maastricht UMC
Edward Schwarz, University of Rochester Medical Center
Josh Wenke, PhD, US Army Institute of Surgical Research

Orthopaedic infections are a common and devastating condition to patients.  Despite constant modifications in practice, infection rates for many conditions and surgeries remained relatively unchanged for decades.  This RIG will be a forum where clinicians, engineers, and biologists disseminate and discuss the issues, approaches, and discoveries. The topic will be broken into prevention, diagnosis, and treatment. The 2020 meeting will focus on prevention with future RIGs covering diagnostics and treatment.  Clinicians will describe the problems, challenges and current practices.  More importantly, their perspective on what is needed to reduce and effectively treat infections will be shared so the audience gains the insight required to target their innovations. Findings from recent consensus panels on the topic of infection will also be shared and discussed to include a list of “hot topics.”  We aim to build a dedicated infection research community presence during future ORS meetings.

Intro and What is a Research Interest Group (RIG)?
Chris Arts, PhD, Maastricht UMC
Josh Wenke, PhD, US Army Institute of Surgical Research

Scope and intentions with Musculoskeletal Infection (MSKI) RIG 2020-2023
Chris Arts, PhD, Maastricht UMC
Josh Wenke, PhD, US Army Institute of Surgical Research

The Gap Areas for prosthetic joint infection (PJI) and Fracture Related Infection (RFI)   
Hamish Simpson, MD, PhD, University of Edinburgh

Prevention: The microbiome and periprosthetic joint infection
Chris Hernandez, PhD, Cornell University

What is protective host immunity?          
Gowri Muthukrishnan, PhD, University of Rochester Medical Center

Clinical experience and health economic assessment of S53P4 Bioactive glas in one-stage osteomyelitis treatment
Jan Geurts, MD, PhD, Maastricht University Medical Center

Panel Discussion

View the Recording                               

 

12:15 PM – 1:45 PM

The role of senescent cells in muscle aging and disease as well as their implication in the cross talk between skeletal muscle and bone

Organizers:
Rick Lieber, PhD, Shirley Ryan AbilityLab
Sudheer Ravuri, PhD, Steadman Philippon Research Institute 

The goal of this RIG is to enhance the collaboration between clinics and laboratories, and to discuss new and cutting-edge muscle research. The RIG will also describe the current knowledge or technical gaps and barriers to solving the muscle research problem. The RIG will focus on muscle aging and cross talk between muscle and bone. There will be a didactic portion, with ample time for an interactive discussion and questions at the end of the meeting.

The RIG will begin with a 60-minute didactic portion taught by one of the leading pioneers of muscle cell therapy and muscle aging, Johnny Huard, PhD, Stedman Philippon Research Institute. For the final 30 minutes, there will be an interactive question and answer session between the audience and presenters. At the completion of the RIG, attendees will have a greater understanding and appreciation of mechanism of muscle aging and its cross talk with bone that can help us to develop innovative approaches for muscle regeneration and disease treatment.

6:30 PM – 8:30 PM

Organizers:
L. Daniel Latt, MD, PhD, University of Arizona
William Ledoux, PhD, VA Puget Sound
Bart Lubberts, MD, PhD, Massachusetts General Hospital
E. Meade Spratley, PhD, University of Virginia

Foot and ankle surgery is one of the newest and fastest growing areas of orthopaedic surgery. Relatively little is known about the foot in comparison to anatomic regions that have long been the subject of orthopedic research. Foundational (basic science) research in foot and ankle surgery will need to expand rapidly to keep pace with the clinical practice and applied research.

The Foot and Ankle RIG will advance the science underpinning foot and ankle care by promoting communication and fostering collaborations among individuals interested in foot and ankle science.

Invited Speaker:

Evolution of foot and ankle modeling and clinical applications
Gerald Harris, PhD, PE
Marquette University
Medical College of Wisconsin
Shriners Hospital, Chicago

Poster Pitch Session

6:30 PM – 8:30 PM

Organizers:
Ahmet Erdemir, PhD, Cleveland Clinic
Carl Imhauser, PhD, Hospital for Special Surgery

Simulation is a highly effective tool in orthopaedic research and naturally it has been adapted increasingly in the biomechanics community. There is a large variety of resources (data, software, models, and workflows) to leverage computational modeling in scientific studies. However, the need to ensure these resources are F.A.I.R. (findable, accessible, interoperable, reproducible) is pressing. Similarly, procedures to establish and communicate credibility of computational models and simulations are fragmented. The goal is to establish a platform where computational biomechanics enthusiast can organize, communicate, share resources and experiences, and promote effective and appropriate use of simulation for scientific discovery and healthcare. A brief presentation will summarize the main concepts and current landscape followed by a panel discussion with panelists across the spectrum of academic generations, from students to established investigators.

Invited Speaker:

The Landscape to Build Computational Models and Make them F.A.I.R. and Credible
Ahmet Erdemir, PhD, Cleveland Clinic

Poster Pitch Session

6:30 PM – 8:00 PM

Organizers:
Tim M. Griffin, PhD, Oklahoma Medical Research Foundation
Tom Andriacchi, PhD, Stanford University
Richard Loeser, MD, University of North Carolina
Rachel Miller, PhD, Rush University

The goal of this RIG is to leverage the interdisciplinary strengths of the ORS and OARSI to stimulate and propose new strategic scientific approaches and patient-centric recommendations that exist at the interface between disciplines to address OA. The discussion theme this year will focus on OA pain mechanisms, phenotypes, and treatments under an interdisciplinary format that integrates elements of mechanics, biology and tissue structure. The presentations and discussion will focus on translation of basic science research to clinically relevant patient-focused outcomes.

Molecular therapies for chronic OA pain: Models and mechanisms
Tonia Vincent, MD, PhD, Professor, Kennedy Institute of Rheumatology

Peripheral modulation of OA pain: Integrating mechanics and inflammation
Rachel Miller, PhD, Assistant Professor, Rush University

Joint remodeling and gait adaptations: The intersection of pain and biomechanics
Kyle Allen, PhD, Associate Professor, University of Florida

Pain susceptibility phenotyping in OA patients: A path for personalized treatments?
Lisa Carlesso, PT, PhD, Assistant Professor, McMaster University

Panel Discussion

Monday, February 10

7:15 PM – 9:00 PM

Organizers:
Alessandra Carriero, PhD, The City College of New York
Victor Huayamave, PhD, Embry-Riddle Aeronautical University
Megan Killian, PhD, University of Delaware
Chad Price, MD, International Hip Dysplasia Institute (IHDI)

This inaugural RIG will bring together basic scientists, translational researchers and clinicians interested in studying hip dysplasia and other structural hip disorders with opportunities to discuss scientific and clinical approaches to improve outcomes in patients. The first part of the RIG will feature invited speakers with open discussion to follow. The RIG will work together to define pathways to move research and clinical practice forward. Guidelines and future research directions will be discussed. Plans for sharing knowledge and resources will be considered.

Part 1

Invited Speakers:

Hip dysplasia: Clinical perspective
Chad Price, MD, International Hip Dysplasia Institute (IHDI)

Neonatal modeling of hip dysplasia and Pavlik harness method
Victor Huayamave, PhD, Embry-Riddle Aeronautical University 

Shaping our hips: The role of mechanical forces on joint morphogenesis and bone growth
Alessandra Carriero, PhD, The City College of New York

Morphology and mechanics of structural hip disease
Andrew Anderson, PhD, University of Utah Orthopaedics

Animal models for hip dysplasia
Megan Killian, PhD, University of Delaware

Part II   Open Discussion

The RIG will work together to define pathways to move research and clinical practice forward. Guidelines and future research directions will be discussed. Plans for sharing knowledge and resources will be considered.