The ORS is thrilled to announce that the South Korea has been selected as the 2021 Guest Nation. The Guest Nation Program honors our colleagues in South Korea and recognizes their contributions to the field of musculoskeletal research and orthopaedic care.
Organized by: South Korea (Guest Nation)
Organizers: Jung Ho Park, MD and Tae Joon Cho, MD, PhD
The speakers will discuss Bone, Cartilage and Tendon and Ligament.
Shin Yoon Kim, MD, PhD, Kyungpook National University
Chul Won Ha, MD, PhD, Samsung Medical Center
Tendon and Ligament
Chris Jo, MD, PhD, Seoul National University
How Close Are We to an Ideal Cartilage Repair?
Byoung-Hyun Min, MD, PhD
Ajou University Medical Center
Guest Nation: South Korea
The successful clinical report of ACI in 1994 has paved way for tremendous advances in cell therapy for cartilage repair.
What started from autologous chondrocytes, we can now utilize allogenic stem cells thanks to the advances in stem cell biology. Technological advances in biomaterials has also led to utilization of various natural material scaffolds.
Despite these progresses, it is still difficult to say that cell therapy is an ideal treatment modality for cartilage defects. Many questions remain unanswered, such as the survivorship of implanted cells. Furthermore, there is little evidence that scaffolds provide the ideal environment for cells to differentiate and secrete appropriate extracellular matrices, and some evidence even suggest that scaffolds interfere with the repair process overall. Not surprisingly, recent research reveals that cartilage repair depends more on the migration of host cells rather than the differentiation of implanted cells.
The ideal mode of action of cell therapy would involve the survival and subsequent production of extracellular matrix of implanted cells. Ideal scaffolds would be of cartilage extracellular matrix material that would serve as vehicles of cell delivery and participate in cartilage repair and host remodeling without degradation.
Scaffold free cartilage engineering has recently proved to improve many limitations of previous cartilage repair strategies and preserve the intended mode of action of cartilage repair.
Tae Joon Cho, MD
President, Korean Orthopaedic Research Society