RIGs foster the thoughtful exchange of ideas within the global multi-disciplinary community of the ORS by providing the opportunity to engage in informative, transformative, and live discussion with colleagues in a specific area of musculoskeletal research, whether basic, applied, clinical, and/or orthopaedic. To explore content that is complementary or different to the ORS Annual Meeting, RIGs are encouraged to focus on unique approaches, methodologies, diseases, or connections that inspire brainstorming across our multi-disciplinary groups.
Friday, February 12, 2021
1:00 PM – 2:00 PM
Support provided by:
Organizers:
Daniel Latt, MD, University of Arizona
William Ledoux, PhD, VA Puget Sound
Meade Spratley, PhD, University of Virginia
Bart Lubberts, MD, PhD, Massachusetts General Hospital
The foot and ankle is one of the newest and fastest growing areas of orthopaedic research. Relatively little is known about the foot in comparison to anatomic regions, such as the hip and knee, that have long been the subject of orthopaedic studies. Foundational (basic science) research in the foot and ankle will need to expand rapidly to keep pace with the clinical practice and applied research. The Foot and Ankle RIG will advance the science underpinning foot and ankle care by promoting communication and fostering collaborations among individuals interested in foot and ankle research. It’s goal is to serve as a network to facilitate the interaction between basic scientists, translational researchers, and clinicians interested in collaborating on foot and ankle orthopaedic science.
How our Understanding of 3D Kinematics of the Foot and Ankle Gained from Weight Bearing CT is Changing Clinical Practice and Research
Scott Ellis, MD, Hospital for Special Surgery
Assignment of Local Coordinate Systems and Methods to Calculate Tibiotalar and Subtalar Kinematics
Karen Kruger, PhD, Marquette University and Amy Lenz, PhD, University of Utah
Poster Teaser Presentations
Saturday, February 13
1:30 PM – 3:00 PM
Organizers:
Antonia F. Chen, MD, MBA, Brigham and Women’s Hospital
Noreen Hickok, PhD, Thomas Jefferson University
Amber Jennings, PhD, University of Memphis
Musculoskeletal infections are a common and a devastating complication in orthopaedics, particularly when implants are required to restore function. The challenge of preventing or eliminating infection in bone has been met with several new advances in therapeutic approaches and clinical practice; however, infection rates remain at an unacceptable level. This RIG will be a forum where clinicians, engineers, and biologists discuss the challenges and highlight new approaches and discoveries. The topic of infection will be broken into the 3B’s of orthopaedic infection: biofilm, bone, and biomaterials; the focus of this RIG 2021 meeting will be on understanding the interaction between biofilm-associated bacteria with immune and bone tissues, as well as opportunities for designing more effective biomaterial therapies for infection. We aim to continue building a dedicated infection research community presence during future ORS meetings.
Clinically Reliable Anti-infection Biomaterials for Bone Repair: Do they Exist?
David Grainger
New Biomaterials on the Horizon for Orthopaedic Infection
Bingyun Li
A Bug’s Eye View of Biofilm-associated Orthopaedic Infection
Mark Smeltzer
Staphylococcus Aureus Biofilm Promotes Leukocyte Dysfunction during Orthopaedic Infection
Tammy Kielian
The Role of the Immune System in a Mouse Model of Periprosthetic Joint Infection
Matthias Bostrom
Hide and Seek: Are We Reaching Biofilm in Bone?
Amber Jennings
Monday, February 15, 2021
3:00 PM – 4:30 PM
Organizers:
Rachel E. Miller, PhD, Rush University Medical Center
Tim M. Griffin, PhD, Oklahoma Medical Research Foundation
Interdisciplinary approaches are needed to address OA as a complex heterogeneous disease involving multiple organ systems and connective tissues. This complexity poses substantial challenges for developing new solutions to treat and prevent OA, which is now considered a serious disease. The goal of this program is to leverage the interdisciplinary strengths of ORS and OARSI to stimulate and propose new strategic scientific approaches and patient-centric recommendations that exist at the interface between disciplines to address OA. The discussion theme this year will focus on innovative approaches to study OA pain under an interdisciplinary format that integrates elements of inflammation, pain biology and mechanics. The presentations and discussion will focus on translation of research to clinically relevant patient-focused outcomes. Overall, we hope that this group will provide an opportunity for OA researchers to interact during this virtual meeting.
Relationship Between Inflammation and Pain in Osteoarthritis
Carla R. Scanzello, MD PhD, University of Pennsylvania
Translational Considerations – Preclinical Assessments of Pain
Tamara King, PhD, University of New England
In Vivo Imaging, Muscle Neuromechanics, and Rehabilitation for OA Prevention
Jason Franz, PhD, University of North Carolina at Chapel Hill
Monday, February 15
3:00 PM – 4:30 PM
Organizers:
Hannah Dailey, PhD, Lehigh University
Carl Imhauser, PhD, Hospital for Special Surgery
Ahmet Erdemir, PhD, Cleveland Clinic
Computational models have been used for decades in musculoskeletal biomechanics, but their direct impact on patient care remains limited. To impact practice, models need to add value by offering patient-level insights unattainable any other way. This emerging frontier for modeling as a tool for diagnosis, prognosis, or surgical planning shows clear potential, but barriers to clinical translation remain. This RIG will address questions including: What are the opportunities to improve outcomes through model-informed decision-making across an episode of care? What are the keys to gaining clinical acceptance for a model? How should modelers balance the competing demands of fidelity, complexity, interpretability, reproducibility, and cost? Can physics-based modeling and machine learning be leveraged synergistically? The session will include case studies of models that address unmet needs in orthopaedic practice and a panel of speakers will engage participants in a collaborative discussion.
Biomechanics Visualization Software for Surgeons: Education vs. Preoperative Planning
Greg Lewis, PhD, Penn State
Challenges to Clinical Implementation of Analytic Models in Orthopaedic Surgery
Nicholas Giori, MD, PhD, Stanford University
FEA and DEA Models in the Hip and Knee: A Surgeon’s Perspective
Robert Westermann, MD, University of Iowa
Good Simulation Practice: Current Regulatory Requirement and Future Opportunities
Marc Horner, PhD, ANSYS, Inc.
Tuesday, February 16
9:30 AM – 11:00 AM
Organizers:
Gretchen A. Meyer, PhD, Washington University
Lucas R. Smith, PhD, University of California, Davis
This RIG will highlight recent insights into skeletal muscle regeneration provided by cutting-edge cell-targeted tools such as single-cell transcriptomics and epigenetic profiling. The traditional view of the satellite cell as the lone ranger of muscle regeneration is eroding as single-cell sequencing identifies subpopulations of macrophages, fibro/adipogenic progenitors and satellite cells whose cross-talk is essential for muscle homeostasis and repair. Disrupted population dynamics and intercellular signaling drive pathology. Identifying critical cell-cell interactions will uncover novel therapeutic targets in sarcopenia, dystrophies and metabolic disorders; improving surgical and rehabilitative outcomes. This RIG will feature two speakers who are leaders in uncovering the cellular complexities of muscle regeneration. An interactive session will follow fostering discussion of the translational potential of these cell-targeted tools in muscle and orthopaedic research in general.
Dissecting Stem Cell Regulation in Skeletal Muscle Regeneration and Aging Through Single-cell Transcriptomics
Benjamin Cosgrove, PhD, Cornell University
Functional Interactions Between Specific Muscle-Resident Cell Types in Response to Different Homeostatic Perturbations of Skeletal Muscles
Pier Lorenzo Puri, MD, Sanford Burnham Prebys Medical Discovery Institute
*RIG schedule subject to change.
