2023 Philadelphia Spine Research Society (PSRS) Symposium

Friday, November 3rd, 2023

At Drexel University

Mitchell Auditorium, Bossone Research Center

3140 Market Street, Philadelphia, PA 19104


7:30 – 9:00 AM    Poster Setup

8:00 – 9:00 AM    Registration and Breakfast

9:00 – 9:05 AM    Welcome Remarks:  Sriram Balasubramanian, PhD, Drexel University Meeting Chair

Session One – Development and Pediatric Disorders

Moderator: Neil Malhotra, MD

9:05 – 9:35 AM    Keynote Talk (20-minute talk + 10 minutes for Q&A)

Title: New insights on cavitation in developing synovial joints during mouse embryo skeletogenesis

Speaker: Maurizio Pacifici, PhD, The Children’s Hospital of Philadelphia, Philadelphia, PA

9:35 – 10:35 AM    Podium Presentations (10 minutes + 2 minutes for Q&A each)

Influence of Age on Immune Cell-Modulated Annulus Fibrosus Repair in a Mouse Disc Herniation Injury Model

Timothy Jacobsen, Mount Sinai School of Medicine

Transcriptomic Analysis of Murine Intervertebral Disc Reveals Anatomical Spine Level-Dependent Differences in Immune Regulatory Pathway

Mark, Min Kyu Kim, Columbia University

Hierarchical Evaluation of Mechanically Induced Growth Modulation of the Spine in a Growing Pig Model

Madeline Boyes, University of Pennsylvania

An (Increasingly) Automated Framework for Simulation of Adolescent Idiopathic Scoliosis Curve Progression and Correction with Anterior Vertebral Body Tethering

Christian D’Andrea, Drexel University

Mechanisms of Facet Degeneration Adjacent to Engineered Discs Implanted with Plate Fixation

Sarah Gullbrand, University of Pennsylvania

10:35 – 10:50 AM    Refreshment Break

Session Two – Aging, Degeneration and Injury

Moderators: Makarand Risbud, PhD & Edward Vresilovic, MD, PhD

10:50 – 11:20 AM    Keynote Talk (20-minute talk + 10 minutes for Q&A)

Title: Clinically relevant models of discogenic back pain for therapeutic intervention

Speaker: Devina Purmessur Walter, PhD, The Ohio State University, Columbus, OH

11:20 – 12:20 PM    Podium Presentations (10 minutes + 2 minutes for Q&A each)

IRT6 is critical in maintaining intervertebral disc homeostasis

Pranay Ramteke, Thomas Jefferson University

Oral K3Citrate Supplementation Mitigates Age-Associated Intervertebral Disc Mineralization in LG/J Mice

Olivia Ottone, Thomas Jefferson University

Ex Vivo Optimization and In Vivo Measurement of Nucleus Pulposus Oxygen, Glucose, and Lactate in a Goat Model of Disc Degeneration

Karthikeyan Rajagopal, University of Pennsylvania

Link N Regulates IL-1β and Inflammasome Activity in the Intervertebral Disc through Interaction with CD14

Muskan Alad, Lady Davis Institute for Medical Research, Montreal, QC, Canada, and McGill University, Montreal, QC, Canada

Acute and Chronic Changes in Spinal Cord Sensitization and Neuroinflammation After Annulus Fibrosus Injury in a Rat Discogenic Pain Model

Denise Carmen Iliff, Icahn School of Medicine at Mount Sinai

12:20 – 2:30 PM    Lunch and Poster Session (Bossone third floor atrium)

Please see the detailed Poster Presentation List

Session Three – Therapeutics, Imaging and Biomarkers

Moderators: Lachlan Smith, PhD & Thomas Schaer, VMD

2:30 – 3:00 PM    Keynote Talk (20-minute talk + 10 minutes for Q&A)

Title: Immunomodulatory Therapy in the Repair of Intervertebral Disc Degeneration

Speaker: Nadeen O. Chahine, PhD, Columbia University, New York, NY

3:00 – 4:00 PM    Podium Presentations (10 minutes + 2 minutes for Q&A each)

Therapeutic Treatment for Regulation of RhoA Pathway in Intervertebral Disc Degeneration

Gabriella Bond, Columbia University

Intervertebral Disc Repair Using Adhesive and Non-Adhesive Injectable Hydrogels in an Ovine Discectomy Model

Christopher J. Panebianco, University of Pennsylvania

Assessing the Effect of PROTAC 753b Senolytic on Intervertebral Disc Aging

Peter G Alexander, University of Pittsburgh

Examining herniated human intervertebral discs using single-cell RNA sequencing reveals a dominant role of small populations of macrophages and fibroblasts in driving the pro-inflammatory environment and fibrosis

Jennifer Gansau, Icahn School of Medicine at Mount Sinai

An Analysis of Poly-Ether Ketone Ketone Compared to Titanium Interbody Cages for Patients Undergoing Anterior Cervical Discectomy and Fusion: A Prospective Study

Philip Paschal, Hospital for Special Surgery

4:00 – 4:15 PM    Refreshment Break

Session Four – Artificial Intelligence and Machine Learning in Spine Research

Moderator: Dawn Elliott, PhD

4:15 – 4:45 PM    Keynote Talk (20-minute talk + 10 minutes for Q&A)

Title: QdMRI with AI and their applications in thoracic insufficiency syndrome (TIS)

Speaker: Yubing Tong, PhD, University of Pennsylvania, Philadelphia, PA

4:45 – 5:45 PM    Podium Presentations (10 minutes + 2 minutes for Q&A each)

Automated Vertebral landmark point identification using Deep Learning

Girish Viraraghavan, Drexel University

Automated 3D U-Net Semantic Segmentation of Lumbar Vertebrae in MR Scans for Enhanced Preoperative Spinal Assessment

David Barreto, University of Pennsylvania – Perelman School of Medicine

Assessing Disability and Functional Outcome Measurements Using Spinal-Specific Wearables and Machine Learning to Improve Spinal Patient Care

Ram Haddas, University of Rochester Medical Center

Exploring mechanisms of acute to chronic low back pain: Does sleep disturbance enhance and maintain pain in rats with either lumbar disc injuries or chronic nerve constriction injury?

Mary Barbe, Temple University

Association between Leptin plasma concentration, pain, and function in Chronic Low Back Pain subjects

Valerio Tonelli Enrico, University of Pittsburgh

5:45 – 6:15 PM    Presentation of Awards and Concluding Remarks

6:15 – 8:00 PM   Networking Reception (Bossone lobby)