2023 Philadelphia Spine Research Society (PSRS) Symposium
Friday, November 3rd, 2023
At Drexel University
Mitchell Auditorium, Bossone Research Center
3140 Market Street, Philadelphia, PA 19104
PROGRAM AGENDA
7:30 – 9:00 AM Poster Setup
8:00 – 9:00 AM Registration and Breakfast
9:00 – 9:05 AM Welcome Remarks: Sriram Balasubramanian, PhD, Drexel University Meeting Chair
Session One – Development and Pediatric Disorders
Moderator: Neil Malhotra, MD
9:05 – 9:35 AM Keynote Talk (20-minute talk + 10 minutes for Q&A)
Title: New insights on cavitation in developing synovial joints during mouse embryo skeletogenesis
Speaker: Maurizio Pacifici, PhD, The Children’s Hospital of Philadelphia, Philadelphia, PA
9:35 – 10:35 AM Podium Presentations (10 minutes + 2 minutes for Q&A each)
Influence of Age on Immune Cell-Modulated Annulus Fibrosus Repair in a Mouse Disc Herniation Injury Model
Timothy Jacobsen, Mount Sinai School of Medicine
Transcriptomic Analysis of Murine Intervertebral Disc Reveals Anatomical Spine Level-Dependent Differences in Immune Regulatory Pathway
Mark, Min Kyu Kim, Columbia University
Hierarchical Evaluation of Mechanically Induced Growth Modulation of the Spine in a Growing Pig Model
Madeline Boyes, University of Pennsylvania
An (Increasingly) Automated Framework for Simulation of Adolescent Idiopathic Scoliosis Curve Progression and Correction with Anterior Vertebral Body Tethering
Christian D’Andrea, Drexel University
Mechanisms of Facet Degeneration Adjacent to Engineered Discs Implanted with Plate Fixation
Sarah Gullbrand, University of Pennsylvania
10:35 – 10:50 AM Refreshment Break
Session Two – Aging, Degeneration and Injury
Moderators: Makarand Risbud, PhD & Edward Vresilovic, MD, PhD
10:50 – 11:20 AM Keynote Talk (20-minute talk + 10 minutes for Q&A)
Title: Clinically relevant models of discogenic back pain for therapeutic intervention
Speaker: Devina Purmessur Walter, PhD, The Ohio State University, Columbus, OH
11:20 – 12:20 PM Podium Presentations (10 minutes + 2 minutes for Q&A each)
IRT6 is critical in maintaining intervertebral disc homeostasis
Pranay Ramteke, Thomas Jefferson University
Oral K3Citrate Supplementation Mitigates Age-Associated Intervertebral Disc Mineralization in LG/J Mice
Olivia Ottone, Thomas Jefferson University
Ex Vivo Optimization and In Vivo Measurement of Nucleus Pulposus Oxygen, Glucose, and Lactate in a Goat Model of Disc Degeneration
Karthikeyan Rajagopal, University of Pennsylvania
Link N Regulates IL-1β and Inflammasome Activity in the Intervertebral Disc through Interaction with CD14
Muskan Alad, Lady Davis Institute for Medical Research, Montreal, QC, Canada, and McGill University, Montreal, QC, Canada
Acute and Chronic Changes in Spinal Cord Sensitization and Neuroinflammation After Annulus Fibrosus Injury in a Rat Discogenic Pain Model
Denise Carmen Iliff, Icahn School of Medicine at Mount Sinai
12:20 – 2:30 PM Lunch and Poster Session (Bossone third floor atrium)
Please see the detailed Poster Presentation List
Session Three – Therapeutics, Imaging and Biomarkers
Moderators: Lachlan Smith, PhD & Thomas Schaer, VMD
2:30 – 3:00 PM Keynote Talk (20-minute talk + 10 minutes for Q&A)
Title: Immunomodulatory Therapy in the Repair of Intervertebral Disc Degeneration
Speaker: Nadeen O. Chahine, PhD, Columbia University, New York, NY
3:00 – 4:00 PM Podium Presentations (10 minutes + 2 minutes for Q&A each)
Therapeutic Treatment for Regulation of RhoA Pathway in Intervertebral Disc Degeneration
Gabriella Bond, Columbia University
Intervertebral Disc Repair Using Adhesive and Non-Adhesive Injectable Hydrogels in an Ovine Discectomy Model
Christopher J. Panebianco, University of Pennsylvania
Assessing the Effect of PROTAC 753b Senolytic on Intervertebral Disc Aging
Peter G Alexander, University of Pittsburgh
Examining herniated human intervertebral discs using single-cell RNA sequencing reveals a dominant role of small populations of macrophages and fibroblasts in driving the pro-inflammatory environment and fibrosis
Jennifer Gansau, Icahn School of Medicine at Mount Sinai
An Analysis of Poly-Ether Ketone Ketone Compared to Titanium Interbody Cages for Patients Undergoing Anterior Cervical Discectomy and Fusion: A Prospective Study
Philip Paschal, Hospital for Special Surgery
4:00 – 4:15 PM Refreshment Break
Session Four – Artificial Intelligence and Machine Learning in Spine Research
Moderator: Dawn Elliott, PhD
4:15 – 4:45 PM Keynote Talk (20-minute talk + 10 minutes for Q&A)
Title: QdMRI with AI and their applications in thoracic insufficiency syndrome (TIS)
Speaker: Yubing Tong, PhD, University of Pennsylvania, Philadelphia, PA
4:45 – 5:45 PM Podium Presentations (10 minutes + 2 minutes for Q&A each)
Automated Vertebral landmark point identification using Deep Learning
Girish Viraraghavan, Drexel University
Automated 3D U-Net Semantic Segmentation of Lumbar Vertebrae in MR Scans for Enhanced Preoperative Spinal Assessment
David Barreto, University of Pennsylvania – Perelman School of Medicine
Assessing Disability and Functional Outcome Measurements Using Spinal-Specific Wearables and Machine Learning to Improve Spinal Patient Care
Ram Haddas, University of Rochester Medical Center
Exploring mechanisms of acute to chronic low back pain: Does sleep disturbance enhance and maintain pain in rats with either lumbar disc injuries or chronic nerve constriction injury?
Mary Barbe, Temple University
Association between Leptin plasma concentration, pain, and function in Chronic Low Back Pain subjects
Valerio Tonelli Enrico, University of Pittsburgh
5:45 – 6:15 PM Presentation of Awards and Concluding Remarks
6:15 – 8:00 PM Networking Reception (Bossone lobby)
