8:00 AM – 4:00 PM
Part II of our popular LearnORS Art of Grant Writing online course is the interactive portion of the course, occurring at the Annual Meeting. Participants will be paired with experienced mentors to go over their proposals and provide valuable feedback on the art of grant writing. The interactive day-long course includes a Specific Page Aims Lab providing participants with the opportunity to prepare and revise a specific aims page, the most important page of the grant application. In addition, a subset of full grants submitted by registrants will be reviewed during a LIVE Mock NIH Study Section. Additional didactics highlight important concepts to supplement the Part I LearnORS materials. The day ends with a networking reception. Don’t miss out on the networking and mentoring opportunities and the real time feedback you will receive from faculty and NIH officers.
Registration fee:
ORS Members: $110
Non-Members: $160
We encourage you to take Part I (online lectures) prior to participating in the Part II to ensure maximum success! Full grant proposals will be accepted for review only from registrants who have participated in Part I of this course.
10:00 AM – 3:00 PM
This Session is being recorded and will be available on the ORS 2023 Annual Meeting Virtual Platform following the live session.
Complete Voting on the 2023 ORS MSKI ICM Questions
Organizers: Fintan Moriarty, PhD, Edward Schwarz, PhD, Noreen Hickok, PhD, Tom Schaer, VMD, Kordo Saeed, MD, Antonia Chen, MD, MBA
There is no fee to attend this session, but registration required.
1:00 PM – 5:00 PM
Translating Orthopaedic Pain Measurements: From Preclinical Models to Clinical Patients
Session 1: Orthopaedic Pain Mechanisms in Rodent Models
Rachel Miller, PhD – Rush University
Session 2: Orthopaedic Pain Mechanisms in Human Patients: Monitoring and Treatment
Nancy Lane MD – University of California, Davis
Session 3: Behavior and Artificial Intelligence: how precision tools can be used for fast, accurate, and real-time animal monitoring
Isabella Condotta, PhD – University of Illinois at Urbana-Champaign
1:00 PM – 6:00 PM
Practical considerations for applying and interpreting AI/ML models in orthopaedics
Location: Coronado BCD, Hilton Anatole, Dallas TX
Time: 1-6 pm Friday, Feb 10th
1 – 1:10 pm: Welcome and introduction to the workshop – Josh and Cheryl
1:10 – 2 pm: Invited Talks Session 1
- Jennifer Nichols – Transfer Learning & Explainable AI: Lessons from Computational and Experimental Work in the Upper Limb
- Nathalie Willems – AI-enabled solutions for improving the pre-operative to post-operative journey
2:00 – 2:50 pm: Invited Talks Session 2
- Koren Roach – Developing advanced statistical techniques that predict osteoarthritis and characterize osteoarthritis progression
- Chris Roche – Use of ML to drive evidence based decision making with shoulder arthroplasty, evaluating the accuracy and fairness of clinical outcomes predictions
2:50 – 3:20 pm: Clinical translation of AI/ML
- Ken Urish and the panel (Jen, Nathalie, Koren, and Chris)
3:20 – 3:30 pm: Break
3:30 – 4:20 pm: Keynote – Grace Peng
- Moving towards Digital Twins in Orthopaedics
4:20 – 5:10 pm: Lightning round presentations of accepted papers
- Predictive modeling of patient function and outcome (3 min each)
- Gilmar F Santos – Predicting The Effects Of Prosthetic Alignment On Knee Moment Using Imus And Neural Networks
- R. Kyle Martin – Unsupervised Machine Learning Of The Combined Danish And Norwegian Knee Ligament Registers Identifies Five Discreet Patient Groups With Differing ACL Revision Rates
- Mallika Singh – Liganet: A Multi-modal Deep Learning Approach To Predict The Risk Of Subsequent Anterior Cruciate Ligament Injury After Surgery
- Christian Pean – Predictive Performance Of Machine Learning Algorithms For 30-day Complications After Primary Total Hip And Total Knee Arthroplasty In Racial And Ethnic Minorities
- AI/ML applications in image processing (3 min each)
- Girish Viraraghavan – Automated Vertebral Segmentation Using A Convolutional Neural Network
- William Burton – Automated Patient-Specific Simulation Of Implanted THA Mechanics From CT
- Mallika Singh – Autonoumous Autosegmentation And Landmark Detection Platform For Large Scale Analysis Of Clinically Obtained Hip CT Scans
5:10 – 5:30 pm: Kitware Demo by Beatriz Paniagua
5:30 – 6 pm: Roundtable discussions and networking
3:00 PM – 5:45 PM
Section Members joining remotely will receive access to an audio recording of the Meeting proceedings.
3:00 PM – 3:05 PM – Welcome and Introduction
Katherine Hixon, PhD, Dartmouth College, ORS ISFR Research & Education Committee Chair
3:05 PM – 4:25 pm – ISFR Plenary Session: Mechanobiology of Fracture Healing
Moderators: Katherine Hixon, PhD, Dartmouth Engineering, ORS ISFR Research & Education Committee Chair. Melanie Haffner-Luntzer, PhD, Ulm University, ORS ISFR Research and Education Chair
The basic research perspective: Joel Boerkel, PhD, University of Pennsylvania
The engineering perspective: Martin Stoddart, PhD, AO Research Institute, Davos
The translational perspective: Lukas Engelhardt, PhD, CEO OSORA – Medical Fracture Analytics
The clinical perspective: Will Lack, MD, University of Washington
4:30 PM – 4:50 PM – ISFR Business Meeting
Chelsea Bahney, PhD, The Steadman Clinic & Steadman Philippon Research Institute and University of California San Francisco, OSR ISFR Chair
Hamish Simpson, MA (Cantab), BCh (Oxon), DM (Oxon), FRCS (Eng & Ed), University of Edinburgh, ORS ISFR Chair-Elect
4:50 PM – 5:00 PM – Meeting Break
5:00 PM – 5:45 PM – Emerging Research Leaders in ISFR
ISFR Biennial Meeting Podium Award Winner
Verena Fischer, PhD. Post-Doctoral Fellow, Universitätsklinikum Ulm
ISFR Travel Award Winner
Benjamin Osipov, PhD. Post-Doctoral Fellow, University of California, Davis
ISFR 3 Minute Research Pitch Winner
Torie Duke. PhD Candidate, Oregon Health Science University (OHSU)
ISFR Diversity Award Winner
Nafisa Elghazali. PhD Candidate, University of California San Francisco
5:45 PM – 6:00 PM – ORS ISFR Lifetime Achievement Award Recognition and Lecture
6:00 PM – 7:00 PM – ISFR Networking Event
3:00 PM – 9:00 PM
This Session will Live Stream on the ORS 2023 Annual Meeting Virtual Platform.
Hilton Anatole – Chantilly East
3:00 PM – 3:15 PM
Welcome and Introduction
Lachlan Smith, PhD, Spine Section Chair
Session 1: Enhancing Spine Research through Leadership, Diversity and Mentoring
Moderators: Nadeen Chahine, PhD and Simon Tang, PhD
3:15 PM – 3:45 PM
Cultivating a Supportive Research Environment through Inclusive Leadership
Tristan McIntosh, Ph.D.
Assistant Professor, General Medical Sciences, School of Medicine
Washington University in St Louis, USA
3:45 PM – 4:15 PM
Leading Integration of Diversity, Equity and Inclusion
Zoe Kinias, PhD, Associate Professor of Organizational Behavior
Academic Director of the INSEAD Gender Initiative
Institut Européen d’Administration des Affaires (INSEAD), France
4:15 PM – 4:45 PM
Panel Discussion with Speakers and Moderators
4:45 PM – 5:15 PM
Mentoring Speed-Networking
5:15 PM-6:00 PM
Networking Break and Boxed Dinners
6:00 PM – 6:15 PM
Trainee Poster Teasers
Session 2: Enhancing Spine Research through Collaboration
Moderator: Dino Samartzis, PhD
6:15 PM – 6:45 PM
The iPSpine Chronicles: Where Dreams were Born and Game-Changing Ideas Become Reality
Mariana Tryfonidou, DVM, PhD, Professor of Regenerative Orthopedics
Coordinator, iPSpine Consortium
Utrecht University, Netherlands
Session 3: Leveraging Developmental Biology and Stem Cells for Disc Regeneration
Moderators: Christine Le Maitre, PhD and Nilsson Holguin, PhD
6:45 PM – 7:05 PM
Non-Viral Gene Delivery of Development Factors to Treat Discogenic Back Pain
Devina Purmessur, PhD, Assistant Professor of Biomedical Engineering
The Ohio State University, USA
7:05 PM – 7:25 PM
Lessons Learned from Single Cell Analysis of Developing, Adult and Degenerated Human IVDs for Cell Therapies
Dmitriy Sheyn, PhD, Assistant Professor of Orthopedics
Cedars-Sinai Medical Center, USA
7:25 PM – 8:00 PM
Panel Discussion with Speakers and Moderators
8:00 PM – 9:00 PM
Networking Reception
6:30 PM – 7:30 PM
Registration fee:
ORS Members: $20 ($15 for Student/Post Graduate Trainee Members)
Non-Members: $35
Join us to kick off the ORS Annual Meeting with guided conversations among fellow attendees from all over the world. After opening remarks from our guest, we will take you through group rotations and facilitate opportunities to interact with colleagues you might not otherwise meet. Start establishing connections early to enhance your meeting experience within the community.
8:00 AM – 9:00 AM
Biomaterials – Bone and Soft Tissue Regeneration
Bone – Mechanobiology
Knee Arthroplasty
Cartilage and Synovium – Omics-based Insights into Synovial Joint Biology
Clinical Research – Methods I
Knee – Growth and Development and ACL Injury
9:15 AM – 10:15 AM
This Session will Live Stream on the ORS 2023 Annual Meeting Virtual Platform.
ORS Presidential Address: Marjolein van der Meulen, PhD
ORS President, Dr. Marjolein van der Meulen, will welcome meeting attendees, introduce the ORS Board of Directors and deliver her ORS Presidential Address.
Recognition of 2023 Guest Nation: Ireland
It is our honor and privilege to invite the Royal College of Surgeons in Ireland, Trinity College Dublin, and National University of Ireland Galway to represent Ireland as our ORS 2023 Guest Nation. ORS members from Ireland have contributed significantly to field of orthopaedic research and to the ORS as an organization.
Recognition of Guest Orthopaedic Clinical Society: American Orthopaedic Society for Sports Medicine (AOSSM)
The American Orthopaedic Society for Sports Medicine has been selected to be our ORS 2023 Guest Orthopaedic Clinical Society. AOSSM members have contributed significantly to field of orthopaedic research. Bringing our organizations together in our new Guest Orthopaedic Clinical Society program will only strengthen those bonds and improve collaboration toward our common goals.
ORS 2023 Keynote Speaker: Letitia Bradford, MD, FAAOS, FACS
Lifting as You Climb: Mentorship, Equity, and Inclusion
10:15 AM – 11:15 AM
Authors will be available at EVEN numbered posters.
11:15 AM – 12:15 PM
Spotlight: Musculoskeletal Infection (featuring Edward Schwarz)
Bone – Biology
Intervertebral Disc – Biology
Hip Arthroplasty
Modulators of Inflammation in Knee PTOA
Meniscus – Development and Repair through Lifespan
12:30 PM – 1:30 PM
ORS Industry Alliance Committee
This session will provide guidance on how to present scientific results as they relate to technology and associated techniques to various audiences such as industry representatives, academic scientists, clinicians and their current and prospective patients.
Overcoming the Stigma of Mental Illness
Organizers:
Kharma Foucher, PhD, Penny Atkins, PhD
After the 2022 Annual Meeting workshop on Destigmatizing Mental Illness, participants requested additional support, resources, and community to tackle these issues. Mental health challenges affect persons of all ages, ethnicities, backgrounds, levels of education, and career stages, but can be difficult to discuss openly. Our interest group is focused on continued recognition and destigmatization of mental illness in our community and sharing strategies and resources on supporting each other. Through recognition of the experience of mental illness or mental health challenges, and the benefit of sharing our personal experiences, we hope to build a community of support.
Speakers:
Introduction
DEIC and WLF Mental Health Initiative
Kharma Foucher, PhD, University of Illinois at Chicago
Penny Atkins, PhD, University of Utah
Wendy Ingram, PhD
Founder and CEO
Dragonfly Mental Health
ORS Career Development Committee
Organizers:
Chelsea Heveran and Sarah Greising
Balancing risk in your research portfolio is challenging. Risk tolerance is not static and may change with career stage among many other factors. Furthermore, there exist systemic barriers to adopting riskier research portfolios. The purpose of this session is to (1) share strategies and considerations for identifying and pursuing your optimal level of risk in research and (2) promoting the success of others with ambitions to engage in riskier projects through awareness of attitudes and biases about ‘who can participate in risky research’. This session will target early-career through established researchers.
Speakers:
Risk as a function of time
Deva Chan, PhD
Purdue University
Who gets to Innovate?
Christopher Hernandez, PhD
University of California San Francisco
Planning for risk and innovation
Alayna Loiselle, PhD
University of Rochester
Risk, innovation, and keeping your lab open
Tony Kirilusha, PhD
National Institutes of Health
12:30 PM – 2:00 PM
Changes in the Publication Industry: Peer-review, Preprints and Publicity
Organizer: JOR Editor in Chief Linda Sandell, PhD
Speakers:
Joel Boerckel, University of Pennsylvania
Megan Killian, University of Michigan
Linda Sandell, Washington University
With the author at the center, we will discuss models of publication, the mandate for transparency in review and data, the use of preprint servers and eLife, publicizing your publication and the roll of the Orthopaedic Research Society.
12:30 PM – 3:15 PM
Section Members joining remotely will receive access to an audio recording of the Meeting proceedings.
12:30 PM – 1:45 PM
Orthopaedic Implants Members Only
Ensuring Clinical Relevance of Pre-Clinical Models
Organizers: Trey Crisco, PhD, Michael Hast, PhD, and Jeff Bischoff, PhD
Pre-clinical models are increasingly important in predicting the clinical efficacy of implants and devices in a safe and cost-effective manner. The purpose of this session is to provide an overview of animal, bench-top, and computational models, and to discuss the advantages and potential pitfalls of each approach. The session will include talks from industry, clinical, academic, and government experts with experience in pre-clinical modeling who can provide insight on how to effectively design and use models that will be relevant to clinical medicine.
Presenters:
Clinical relevance in an animal model – Is it possible?
Tom P. Schaer, VMD
University of Pennsylvania
Pre-clinical testing – Can it be clinically relevant? A perspective
Bob Hastings
Hastings and Associates, LLC
Preclinical analysis of the bone implant interface, numerical and ex vivo approaches
Heidi-Lynn Ploeg
Queen’s University
Perspective from an FDA Regulator of Orthopedic Devices and Developer of Arthroplasty Standards
John S. Goode
US FDA
1:45 PM – 2:00 pm – Meeting Break
2:00 PM – 3:15 PM
Open to all meeting attendees based on available seating capacity
Hypersensitivity and alternative bearings
Organizers: William Mihalko, MD, PhD, Alexander Christ, MD, and Jonathan Gustafson, PhD.
Adverse tissue reaction related to cobalt and chromium corrosion and wear is a well-known clinical problem. However, the relative biocompatibility of these materials and their potential to cause allergic/hypersensitivity reactions is less well understood. The purpose of this session is to discuss the clinical relevance of metal hypersensitivity, current methods of evaluation, and available technologies to avoid/treat metal allergy.
Metal hypersensitivity of orthopaedic implants: Clinical implications and unmet needs
Bill Mihalko
Campbell Clinic and the University of Tennessee Health Science Center
Hypersensitivity testing in orthopedics
Nadim Hallab
Rush University
Alternative materials in arthroplasty: What can we learn from 50 years of retrievals?
Doug Van Citters
Thayer School at Dartmouth College
Metal hypersensitivity: Are we too sensitive?
Sophia Sangiorgio
Luskin OIC & UCLA
Section Members joining remotely will receive access to an audio recording of the Meeting proceedings.
12:30 PM – 2:00 PM
Strategies in Clinical Research Members Only
2:15 PM – 3:15 PM
Open to all meeting attendees based on available seating capacity
Strategies in Clinical Research Debate
The Solution for Post-Traumatic Arthritis following ACL injuries – Is it a Mechanical or Biological problem?
Featuring Guest Clinical Society: American Orthopaedic Society for Sports Medicine
AOSSM: The solution for post-traumatic arthritis following ACL injuries is mechanical and rehabilitation related (Dr. Drew Lansdown)
vs.
ORS: The solution for post-traumatic arthritis following ACL injuries is biological (Dr. Scott Rodeo)
Moderators: Drs. Ben Ma and Jaimo Ahn
1:45 PM – 3:15 PM
Guest Nation Workshop: Skeletal Mechanobiology: From Fundamentals to Therapeutic Opportunities
This Session will Live Stream on the ORS 2023 Annual Meeting Virtual Platform.
Organizers:
Fergal O’Brien, PhD and Laoise McNamara, PhD
Mechanical stimuli play critical roles in directing skeletal tissue development, are fundamental to skeletal health and can play a role in the aetiology of disease. Physical exercise can have a powerful regenerative effect on skeletal tissues through stimulation of anabolic mechanosensitive cell signalling pathways. However, mechanical loading can also be injurious, and in degenerative conditions such as osteoarthritis, can propagate cell dysfunction and inflammation. Advances in understanding of the roles of specific mechanosensory machinery in response to loading, have highlighted molecular processes that can be targeted to promote regeneration. Improved understanding of the impact of mechanobiology on skeletal tissue development and regulation may enable identification of therapeutic targets, development of precision therapeutics and mechanically regulated biomaterials that promote regeneration, and enable restoration of healthy mechanical environments in disease.
Speakers:
Overview and Introduction
Fergal O’Brien, PhD
Royal College of Surgeons in Ireland
Scaffold-Based Delivery of Nucleic Acid Therapeutics for Enhanced Bone & Joint Repair
Tom Hodgkinson, PhD
Royal College of Surgeons in Ireland
Mechanobiologically Mimetic Model Systems for Studies of Bone Disease
Laoise McNamara, PhD
National University of Ireland Galway
Multi-Scale Mechanobiology of Skeletal Development
Niamh Nowlan, PhD
University College Dublin
Bone-Cartilage Crosstalk; Subchondral Damage and Joint Disease
Oran Kennedy, PhD
Royal College of Surgeons in Ireland
Symposium: Current Trends in the Treatment of Tendinopathies
This Session is being recorded and will be available on the ORS 2023 Annual Meeting Virtual Platform following the live session.
Organizers:
Chad Carroll, PhD and Kathleen Derwin, PhD
Tendinopathy describes a complex multifaceted pathology of the tendon, characterized by pain, decline in function and reduced exercise tolerance. The most common overuse tendinopathies involve the rotator cuff tendon, medial and lateral elbow epicondyles, patellar tendon, gluteal tendons and the Achilles tendon. The prominent histological and molecular features of tendinopathy include disorganization of collagen fibers, an increase in the microvasculature and sensory nerve innervation, dysregulated extracellular matrix homeostasis, increased immune cells and inflammatory mediators, and enhanced cellular apoptosis. Management consists of different exercise and loading programs, therapeutic modalities and surgical interventions; however, their effectiveness remains ambiguous. This symposium brings together three key clinical experts to discuss the short-comings and opportunities of current and emerging approaches to the treatment of tendinopathies.
Speakers:
Conservative Treatment: Is It All About Loading?
Karin Silbernagel, PT, ATC, PhD
University of Delaware
Orthobiologic Treatments
Scott Rodeo, MD
Hospital for Special Surgery
Novel Therapies
Neal Millar, MD, PhD
University of Glasgow
Symposium: Sex Dimorphism and Cartilage
This Session is being recorded and will be available on the ORS 2023 Annual Meeting Virtual Platform following the live session.
Organizers:
Yasin Dhaher, PhD and Paula Hernandez, PhD
Joint injury rates differ substantially between males and females, with females more likely to experience poorer post-injury outcomes than males participating in similar sports. These injuries can cause short- and long-term morbidity and increase the probability of the development of degenerative joint pathologies, such as post-traumatic osteoarthritis. Thus, sexual dimorphism in cartilage structure, mechanics, and biological response to load may contribute to sex disparities in cartilage pathologies. In this symposium, we will seek to present the most recent development exploring sex-specific differences in the mechano-transduction of the cartilage cellular constituency, the composition of cartilage tissue, the aggregate mechanical characteristics, and stress-induced inflammatory responses. We seek to present studies explored at the different scales of synthesis – cellular to human-centric examinations.
Speakers:
Identifying Temporal Features of Stress-Induced Joint Inflammation in Humans: Sex and Endocrine-Specific Signatures
Conner Hutcherson, PhD Candidate
UT Southwestern Medical Center
Cartilage Dimorphism Before Menopause: From Tissue to Cell
Paula Hernandez, PhD
UT Southwestern Medical Center
Sex and Piezo1 Post-ACL: Details of Chondrocyte Mechanotransduction in Female and Male Mice
Whasil Lee, PhD
University of Rochester Medical Center
Workshop: The Need for Standardized Assessment of Skeletal Muscle Quality, Functional Deficit, and Fatiguability
This Session is being recorded and will be available on the ORS 2023 Annual Meeting Virtual Platform following the live session.
Organizer:
Yen-Sheng Lin, PhD and Nitin Jain, MD
Excessive myosteatosis accumulation leads to altered muscle fiber orientation and is associated with muscle inflammation, reduced muscle strength, and physical performance. The type I (slow twitch) and type II (fast twitch) muscle fibers contain oxidative and glycolytic capacity, respectively. The lipid composition and distribution express tissue-specific signatures to offer stability and protection against oxidative stress conditions to lipid membranes. The mechanisms that directly impair the force generation and fatigue followed by the irreversible loss of muscle quantity (sarcopenia) or reversible muscle type shift during myosteatosis is still unknown. Lipid species and rotator cuff myofiber type-specific composition will provide insights into the post-injury cuff muscle oxidative or glycolytic capacity that impacts the muscle function, healing, and fatigability.
Speakers:
3D Ultrasonic Shearwave Elastography in Muscle
Kathryn Nightingale, PhD
Duke University
Quantitative Assessment of Muscle Properties and Function Using Ultrasound Shear Wave Eelastography Imaging
Hugo Giambini, PhD
University of Texas San Antonio
Biomechanical Effects of Total Hip Arthroplasty on the Hip Muscles
Tsung-Yuan Tsai, PhD
Shanghai Jiao Tong University
Assessment of Myosteatosis and Integration of Skeletal Muscle Quality Exam at the Bedside
Yen-Sheng Lin, PhD
University of Texas Southwestern Medical Center
Targeted Lipidomics and Metabolomics Approaches Reveal Potential New Biomarkers of Musculoskeletal Quality and Performance
Marco Brotto, PhD
University of Texas at Arlington
3:30 PM – 4:30 PM
Spotlight: Corrosion, Toxicity and Inflammation in Arthroplasty (featuring William Mihalko)
Spine – Pathophysiology and Mechanisms
NIRA – Mechanisms, Treatment and Therapies
Preoperative and Operative Considerations in Shoulder Injuries
Knee – Mechanics and Computational Modeling
Biomaterials – Cartilage Repair and Regeneration
4:45 PM – 5:45 PM
Tendon and Ligament – ACL Injury and Reconstruction
Spotlight: Mechanical and Biological Evaluation of Spine Function (featuring Grace O’Connell)
A Focus on Translations Research
Biomechanics and Outcomes of Shoulder Arthroplasty
Cartilage and Synovium – Joint Tissue Morphogenesis
Foot and Ankle – Kinematics and Imaging
5:30 PM – 7:00 PM
Join us in the Exhibit & Poster Hall for a Poster Reception.
7:00 PM – 9:00 PM
Organizers:
William Ledoux, L. Daniel Latt, Amy L. Lenz, Karen Kruger
The Foot and Ankle RIG will advance the science underpinning foot and ankle care by promoting communication and fostering collaborations among individuals interested in foot and ankle science. The purpose is to serve as a network to facilitate the interaction between basic scientists, translational researchers, and clinicians interested in collaborating on studies of foot and ankle science.
This session will specifically focus on the biomechanics, outcomes and conditions of the foot and ankle is needed for four reasons: 1) the wide spectrum of pathology and related treatments; 2) the complex anatomy of the foot and ankle; 3) a paucity of biomechanical data; and 4) ongoing challenges in making adequate diagnoses. Discussion around these four topics is expected to ultimately lead to the improvement of clinical care of the foot and ankle patient population.
Speakers:
Bioengineering interventions for the treatment of injury and degeneration in the ankle joint
Claire Brockett, PhD
University of Leeds
Standardizing Terminology, 3D Spatial Orientation, and Relative Positioning of the Foot and Ankle Bones: An Expert Consensus Task Force
Karen Kruger, PhD
Marquette University
and
Amy Lenz, PhD
University of Utah
Poster Pitches
Old and New Methods to Understand Bone Cell Biology
Organizers:
Miguel Dias Castilho and Lilian Plotkin
Our understanding on the mechanisms by which peak bone mass is achieved and eventually lost with aging, on how diseases affect the skeleton, and on the mechanisms of action of bone preserving drugs depend on how well we can quantify the function of bone cells such as osteoblasts, osteoclasts, and osteocytes. While methods to evaluate bone cell number and function using histomorphometry are essential, complimentary new technologies also allow us to go deeper into cell and molecular biology, providing robust information to inform the underlying mechanism. The purpose of this session is to provide an overview of both traditional and state-of-the art methods to evaluate bone cell function, as well as a transparent discussion of the advantages and disadvantages of each method.
Speakers:
Use of histomorphometry/multiplexing/spatial transcriptomics to understand bone cell biology
Thomas Andersen, PhD
University of Southern Denmark
Structural analyses at the bone tissue and cellular levels (microCT/FIB-SEM)
Natalie Reznikov, PhD
McGill University
Spatio-temporal analyses of cortical bone remodeling in vivo using 3D and 4D evaluation of the basic multicellular unit
David Cooper, PhD
University of Saskatchewan
Registration will be required for all meeting attendees.
Registration Fee:
ORS Section Members: $40
ORS Members: $50
Non-ORS Members: $75
Registration will be required for all meeting attendees.
Registration Fee:
ORS Section Members: $40
ORS Members: $50
Non-ORS Members: $75
8:00 AM – 9:00 AM
Cartilage and Synovium – Advances in Osteoarthritis Treatment
Bone – Injury and Healing
NIRA – Bone and Microbiome
Spotlight: Tendon Injury and Therapeutics (featuring Karin Silbernagel)
Clinical Research – Clinical Outcomes and Use
Muscle Response to Injury and Repair
9:15 AM – 10:15 AM
This Session will Live Stream on the ORS 2023 Annual Meeting Virtual Platform.
Presentation of Career Achievement Awards
Women’s Leadership Forum Award
Outstanding Achievement in Mentoring Award
ORS/OREF Distinguished Investigator
Scientific Achievement Awards & Presentations
10:15 AM – 11:15 AM
Authors will be available at ODD numbered posters.
11:30 AM – 12:30 PM
ORS Career Development Committee and ORS Industry Alliance
Organizer:
Blaine Christiansen, PhD & Coen Wijdicks, PhD, MBA
Your CV is critically important for presenting yourself in a variety of professional situations. It is a complete list of your accomplishments as a scientist, leader, and colleague. This program will cover some key aspects of constructing a highly effective CV for both academia and industry. The session will begin with 3 short talks from experts with advice on (1) how to write your first CV as a trainee, (2) how to construct your CV for academia, and (3) how to construct your CV for industry. Following the talks, we will break into small groups for trainees or early-stage investigators to ask specific questions to established experts from academia and industry. Finally, we will regather to share our thoughts and ask the most common questions to the expert panel.
11:15 AM – 12:45 PM
This Session will Live Stream on the ORS 2023 Annual Meeting Virtual Platform.
Guest Clinical Society – American Orthopaedic Society for Sports Medicine (AOSSM)
Identifying novel solutions to unmet clinical needs requires cross-disciplinary expertise and creative brainstorming find targeted and feasible approaches to previously unsolved clinical problems. This Session will combine virtual and in-person scientific sessions to includes a presentation from an industry leader to explain the power and process of effective brainstorming followed by 3-4 short presentations by clinicians that specialize in Sports Medicine describing an unmet clinical need in their field. Attendees will then be divided according to their background into small groups and participate in guided brainstorming of solutions that could address one of the unmet clinical needs. The session will conclude with a report-out and discussion of the brainstorming results.
ORS Diversity, Equity, and Inclusion Committee
Organizers:
Deva Chan, Feini (Sylvia) Qu
Bullying and harassment are endemic in academia, an environment that is built on well-defined hierarchies, power differentials, and competition. Bullying victims may suffer from
stress, burnout, and depression, and many permanently leave academia. While junior trainees and faculty are the most vulnerable, academic bullying affects people from all career stages, including the senior faculty that attempt to mediate harassment cases. How do we protect students, faculty, and staff from abuse, which is often subtle but nonetheless career damaging? The purpose of this workshop is to promote awareness of this critical but
understudied topic and present intervention techniques to effectively recognize and respond to academic power abuse. It will offer insights and encourage discussion on why this is so common and what can be done by researchers from all career stages to drive change in their own communities.
11:30 AM – 12:30 PM
Orthopaedic Research: Beyond the Lab and Into the Classroom
Organizers: Sonia Bansal, PhD, Amy Loya, PhD, Jason Marvin, PhD
Pedagogical career paths are varied, and it is imperative that trainees and faculty in the MSK sciences have an opportunity to engage with best practices in teaching, communication, and outreach. As such, the goal of this session is to create a community of educators and educators-to-be to discuss pedagogical advances, inclusive teaching strategies, justice-focused curricula, and professional development.
Speakers:
Teaching Faculty Roles at R1 Institutions
Lauren Heckelman, MS
Columbia University
Synergistically Teaching and Researching as a Trainee
Christopher Panebianco, PhD
University of Pennsylvania
“Scientist Does It Because It’s Amusing” Research and Teaching Outside of an R1 Institution
John Drazan, PhD
Fairfield University
12:45 PM – 1:45 PM
ORS Career Development Committee
Organizers:
Anne Nichols, Robert Nims
Obtaining funding is critical for advancing your science. Towards this goal of supporting your scientific pursuits, Program Officers serve as a critical conduit between you as an applicant, the funding institutions, and scientific review panels. This session will target orthopedic researchers at various stages of training (trainees, early-career, mid-career, and established investigators) and offer an opportunity for one-on-one and small group networking and discussions with program officers and other officials from various funding agencies.
ORS Industry Alliance Committee and ORS Innovation Network
The purpose of this session is to discuss areas of development in the regulatory field as they relate to Orthopedics, including topics around changing regulations, FDA vs. international regulators, and specific trends being seen.
12:45 PM – 3:30 PM
Section Members joining remotely will receive access to an audio recording of the Meeting proceedings.
12:45 PM – 2:15 PM
Preclinical Models Section Members Only
12:45 – 12:55 – Section business meeting
12:55 – 1:15 – Section Member only Scientific Meeting
- Preclinical Models Around the World
- Poster Pitch Session Featuring Award Finalists
1:15 – 2:15 – Section Member only Scientific Meeting
- Novel Preclinical Models in Orthopaedic Research:
- i-GONAD and other emerging transgenic mouse technologies
- Megan Michalski, DDS, PhD., Van Andel Research Institute, Grand Rapids, MI
- Novel Flexor Tendon Model in Turkeys
- Chunfeng Zhao, M.D., Mayo Clinic, Rochester, MN.
- The trials and tribulations of developing a large animal model of osteochondritis dissecans (OCD)
- Ferenc Toth DVM, PhD, DACVS-LA, University of Minnesota, St. Paul, MN.
- i-GONAD and other emerging transgenic mouse technologies
2:15 PM – 2:30 pm – Meeting Break
2:30 PM – 3:30 PM
All meeting attendees invited to attend based on available seating capacity
- The Importance of Communicating the Value of Preclinical Animal Research to the Public:
- Naomi Charalambakis, PhD., Associate Director of Scientific Policy, FASEB
- Preclinical research with animals plays an essential role in advancing basic understanding of the natural world, promoting the development of treatments for debilitating diseases, and informing public health policy. Frequently, nonscientists misunderstand the use of animals in scientific research, resulting in poor policy and federal funding decisions that negatively impact research productivity and inhibit future trainees from pursuing scientific research. To continue advancing clinical breakthroughs and bolster U.S. scientific competitiveness on the global stage, the scientific community must strengthen its advocacy message with the public about the value of animal research. This talk seeks to share policy insights, best practices, and advocacy resources to facilitate communication with members of the public about this important topic.
Section Members joining remotely will receive access to an audio recording of the Meeting proceedings.
12:45 PM – 2:15 PM
Tendon Section Members Only
12:45 PM – 12:50 PM – Welcome and Introduction
Neal Millar, PhD FRCSEd (Tr&Ortho), University of Glasgow
Nathaniel Dyment, PhD, University of Pennsylvania
12:50 PM – 2:10 PM – Clinical and Research Challenges in Tendon Research
Moderators:
Neal Millar, PhD FRCSEd(Tr&Ortho), University of Glasgow
Nathaniel Dyment, PhD, University of Pennsylvania
12:50 PM – 1:10 PM
Talk 1: Unmet clinical needs in the treatment of tendon disease
Speaker: Scott Rodeo, MD, Hospital for Special Surgery
1:10 PM – 1:30 PM
Talk 2: Current landscape of drug/device research and development for tendon disease
Speaker: Benjamin Freedman, PhD, Harvard University
1:30 PM – 1:50 PM
Talk 3: Challenges with translation of treatments for tendon disease into human patients
Speaker: Kathleen Derwin, PhD, Cleveland Clinic
1:50 PM – 2:10 PM – Panel Discussion
Panelists:
Scott Rodeo, MD, Hospital for Special Surgery
Benjamin Freedman, PhD, Harvard University
Kathleen Derwin, PhD, Cleveland Clinic
Anne Gingery, PhD, Mayo Clinic
Dianne Little, BVSc, MSpVM, PhD, Purdue University
Jennifer Zellers, PT, DPT, PhD, Washington University in St. Louis
2:10 PM – 2:20 PM – Annual State of the Tendon Section
Kathleen Derwin, PhD, Cleveland Clinic, ORS Tendon Research Section Chair
2:20 PM – 2:30 PM – Meeting Break
2:30 PM – 3:30 PM
All meeting attendees invited to attend based on available seating capacity
ORS Tendon Research Section 3-Minute Elevator Pitch Competition
Selected student and post-graduate trainee members will give a short presentation (think “elevator pitch” or short TED talk) to pitch an innovative idea and/or compelling concept related to their past, present, or future research. This competition is designed for participants to communicate your science effectively and sell their ideas to the audience!
Moderators:
Nathaniel Dyment, PhD, University of Pennsylvania
Neal Millar, PhD FRCSEd (Tr&Ortho), University of Glasgow
Section Members joining remotely will receive access to an audio recording of the Meeting proceedings.
12:45 PM – 2:15 PM
Meniscus Section Members Only
Controversies in Meniscal Repair
Prof. Dr. Romain Seil
Orthopaedic Surgeon
Head Division of Neurosciences and Musculoskeletal Diseases, Centre Hospitalier Luxembourg
Dr. Aaron Krych
Consultant, Department of Orthopedic Surgery
Co-Chair, Division of Sports Medicine, Department of Orthopedic Surgery
Professor of Orthopedics, Mayo Clinic, Rochester, MN
2:30 PM – 3:30 PM
All meeting attendees invited to attend based on available seating capacity
Knee and Meniscus FEM: Overview From the Past, of the Present, to the Future
Jason Halloran PhD
Applied Sciences Laboratory
Institute for Shock Physics, Washington State University
Petri Tanska PhD
Senior Researcher | Adjunct Professor (Docent)
Computational Mechanobiology Laboratory
Biophysics Research Group | Department of Applied Physics
University of Eastern Finland, Kuopio, Finland
2:00 PM – 3:30 PM
Symposium: Temporal Implants in Orthopaedics: Current Concepts, Limitations, and Future Directions
This Session will Live Stream on the ORS 2023 Annual Meeting Virtual Platform.
Organizers:
Michael Hast, PhD and Markus Wimmer, PhD
Orthopaedic implants are currently undergoing a transformation from permanent, life-long devices, towards transient, biodegradable tools that are engineered to disappear over time. Applications of biodegradable implants are diverse, ranging from cartilage and soft tissue repair to bone substitution and fracture reconstruction. Over the last 30 years, the development and implementation of biodegradable implants has led to an influx of in vitro experiments, animal models, and clinical trials. Resorbable implants have shown their capacity to avoid some pitfalls that afflict permanent devices (e.g. eventual failure due to fatigue; need for removal in pediatric applications); however, they also introduce a host of new issues. Temporal parameters regarding degradation, biocompatibility, cytotoxicity, and biomechanical strength for a given application must be carefully addressed as part of the design cycle. The breadth and depth of these questions becomes apparent when one considers the different types of implants, the large number of viable materials, and the spectrum of manufacturing techniques that may be used for fabrication. In the end, biodegradable implants are still not a standard in orthopaedics, especially when it comes to commonly performed procedures, such as joint replacements. So where are we with this technology, and will it ever become ubiquitous? The purpose of this symposium is threefold: 1) to provide an update on state-of-the-art biodegradable implants, 2) to identify the shortcomings of current technologies, and 3) to predict the short- and long-term future for implants in this realm. This symposium will consist of three speakers that all have extensive research expertise in the area of biodegradable implant design and application. They will each speak for 20 minutes about their work. This will allow for 30 minutes of robust conversation/Q&A with the audience.
Speakers:
Increasing the Resolution Limits of 3D Printing for Complex, Biodegradable Implants
Paul Dalton, PhD
University of Oregon
Scaffoldless Tissue Engineering Strategies for Rotator Cuff Repair in an Ovine Model
Lisa Larkin, PhD
University of Michigan
Regenerative Engineering and Rehabilitation of the Musculoskeletal Niche
Karina Nakayama, PhD
Oregon Health and Science University
Workshop: New Biomaterials and Technologies in Spine Surgery
This Session is being recorded and will be available on the ORS 2023 Annual Meeting Virtual Platform following the live session.
Organizer:
Gabriela Graziani, PhD
In the treatment of spine conditions, many challenges remain unmet. In particular, from an educational point of view, there is a need to bridge the gap between clinicians, material scientists and researchers, to fully understand the clinical needs and how to address them, as well as the potentiality and range of application of newly developed materials and technologies.
Speakers:
New Technologies in the Regeneration of the Intervertebral Disk: A Clinical Perspective
Gianluca Vadala, MD, PhD
University of Rome
Biomaterial Carriers for Intradiscal Cell Delivery – Evaluation In Vitro and in Organ Models
Sibylle Grad, PhD
AO Research Institute
Spine Fusion by Biomaterials… A Still Open Challenge
Giovanni Brodano, MD
Rizzoli Orthopaedic Institute
Functionalisation of Custom-Made Spinal Implants by Antibacterial, Anti-Tumor Metal-Based Coatings
Gabriela Graziani, PhD
Rizzoli Orthopaedic Institute
New Solutions for Surgical Site Infection in the Spine: Known Complications, Present Concerns and Industrial Perspectives
Zak Kemp, PhD
Arthrex
3:45 PM – 4:45 PM
Spotlight: Multi-Tissue Crosstalk (featuring Rachel Miller)
Spotlight: Bone Cell Heterogeneity (featuring Ling Qin)
NIRA – Clinical Outcomes and Muscle
Challenges in Musculoskeletal Research and Education
Biomaterials – Soft Tissue Regeneration
Resident and Fellow Research Session
5:00 PM – 6:00 PM
This Session will Live Stream on the ORS 2023 Annual Meeting Virtual Platform.
Kappa Delta Elizabeth Winston Lanier Award
Kappa Delta Ann Doner Vaughan Award
Kappa Delta Young Investigator Award
OREF Clinical Research Award
6:00 PM – 7:30 PM
This Session is being recorded and will be available on the ORS 2023 Annual Meeting Virtual Platform following the live session.
ORS Women’s Leadership Forum
Organizers:
Megan Killian, Sarah Greising, Ani Ural
Flexing is a skill that empowers individuals to embrace any challenge and adapt to any change, yielding practical, valuable takeaways that ensure growth. Flexing also helps individuals move ahead when they are confronted with new challenges, or simply want to develop a vital skill. It is a journey that begins with setting a flex goal—stating explicitly what you want to learn and how you want to grow. Once that flex goal is set, you then begin to run experiments, solicit feedback from peers or colleagues, and monitor and tweak your progress on the way to achieving your goal. Flexing can be tailored to each person, allowing you to reflect on your own experiences and incorporate the lessons you learn in the next project you tackle. It’s a growth mindset that will help you become the best version of yourself. Flexing also works with teams and organizations.
In this session, you will hear from Dr. Susan Ashford, Leadership Expert and author of the book The Power of Flexing: Using Small Daily Experiments to Create Big Life-Changing Growth.
There is no fee to attend this session, but registration required.
7:30 PM – 9:00 PM
Registration fee: $40
This networking event immediately follows the Session, The Power of Flexing: Using Small Daily Experiments to Create Big Life-Changing Growth, presented by the ORS’ Women’s Leadership Forum.
All are welcome to continue or join the conversation.
8:00 AM – 9:00 AM
Bone – Treatment and Therapeutics
Hip – Modeling and Image Analysis
NIRA – Biomechanics
Cartilage and Synovium – Chondrocyte Metabolism and Osteoarthritis
Spotlight: Disc Cell Metabolism and Homeostasis (featuring Lisbet Haglund)
Biomaterials – Osseointegration and Bone Healing
9:15 AM – 10:15 AM
This Session will Live Stream on the ORS 2023 Annual Meeting Virtual Platform.
JOR Excellence and Early Career Awards
JOR Spine Early Career Award
Stryker/ORS Women’s Research Fellowship
ON Foundation Keynote Speaker
Prof. Marcy Zenobi-Wong
Architected ! Novel structured scaffolds to instruct regeneration of articular cartilage
10:15 AM – 11:15 AM
Authors will be available at EVEN numbered Posters.
11:15 AM – 12:15 PM
Clinical Research – Omics/Biomarkers
Spotlight: Bone Mechanoregulation (featuring David Hoey)
NIRA – Biomaterials
Basic Science Imaging
Hip – Injury and Functional Analysis
Foot and Ankle – Surgical and Non-surgical Interventions
12:00 PM – 1:30 PM
The top 10 semi-finalists of the Business Innovation Competition will compete during this poster session. Expert judges will score their 1-min elevator pitch and poster content based on ORS BIC scoring system. In addition to the pitch events, the Innovation
Following the competition, the ORS Innovation Network Group will host a networking event to provide an opportunity for participants and ORS members to network with experienced academics, clinical partners, and leading industry judges and supporters. During the ORS Closing Session, the top finalists will be announced and awarded.
12:15 PM – 1:15 PM
ORS Women’s Leadership Forum
Burnout has become a major problem in academia and also industry and many still young people are affected and victims of the consequences. While certainly the condensed and high requirements for an academic and industrial performance are part of this phenomenon, another, probably as important factor is the problem of reduced resilience in many people of the younger generation.
12:15 PM – 1:45 PM
From Genetics to Mechanics: Expanding Our Outlook on OA Target Discovery
Organizers:
Rachel Miller, PhD, Arin K. Oestreich, PhD
Osteoarthritis (OA) as a complex heterogeneous disease involving multiple connective tissues and organ systems. This complexity requires an interdisciplinary approach to address the substantial challenges for developing new solutions to treat and prevent OA. The goal of this program is to leverage interdisciplinary strengths to stimulate and propose new strategic scientific approaches that exist at the interface between disciplines. The discussion theme will focus on the molecular and mechanical signatures of OA and integrate knowledge of genetic, cellular, and gait mechanics to devise targeted preclinical treatment strategies. This interdisciplinary consortium will bring together experts from different fields to discuss critical molecular and mechanical drivers of disease. Finally, this group will provide an opportunity for basic and clinical researchers to discuss innovative approaches to treating OA.
Speakers:
Deciphering pathways governing susceptibility to osteoarthritis
Mick Jurynec, PhD
University of Utah
Pivotal roles of pericellular matrix in cell-matrix cross-talk and disease initiation
Lin Han, PhD
Drexel University
A machine learning approach to investigate the role of gait and physical activity in knee osteoarthritis progression
Kerry Costello, PhD
University of Florida
1:30 PM – 2:30 PM
ORS Industry Alliance Committee and ORS Innovation Network
This session provides practical advice on skills needed to pitch to industry which is an important step in successful translation.
1:30 PM – 3:00 PM
Symposium-Cell, Tissue, and Systemic Crosstalk in Joint Disease
This Session will Live Stream on the ORS 2023 Annual Meeting Virtual Platform.
Organizers:
Tristan Maerz, PhD and Jillian Beveridge, PhD
The concept of crosstalk between tissues within the joint grew from the realization that diarthrodial joints function as an organ, with the health of the organ being dependent on its component tissues. Advances in our scientific knowledge of joint health and disease now acknowledges that the health of tissues are co-dependent: a failure in one tissue leads to failure in another. Thus, the crosstalk between joint tissues plays a central role in modulating joint health and response to trauma. Today, emerging evidence suggests that crosstalk should be considered even more broadly across scales and larger body systems, including cellular communication via systemic routes. The complexity of these multi-tissue, multi-joint and multi-system interactions necessitates new collaborations amongst investigators with once seemingly disparate interests to make meaningful progress towards improving joint health.
The purpose of this symposium is to highlight scientific programs of early-stage investigators that target crosstalk themes from different joints, scales, and systems, followed by an interactive panel discussion of new avenues of collaborative crosstalk research that should be pursued. We will split the program into two parts: First, two presentations will focus on crosstalk within the joint; then, three presentations will cover diverse crosstalk themes between a joint and distant/systemic organ systems. The studies encompass highly original investigations involving cutting edge methodology and diverse animal models of disease. One or two discussion sessions, led by our expert moderators (Karl Lewis, PhD, Cornell University and Tamara Alliston, PhD, University of California San Francisco), will promote an exchange between the audience and our panelists.
Speakers:
Pathogenic Stromal – Immune Crosstalk in Synovium
Tristan Maerz, PhD
University of Michigan
Mechanobiology Crosstalk in the Knee
Jillian Beveridge, PhD
Rhode Island Hospital/Warren Alpert Medical School of Brown University
Muscle-fat Crosstalk: The Intersection of Adipose Phenotype and Disease
Gretchen Meyer, PhD
Washington University
Calming the Inflammatory Noise Following Joint Instability to Reduce Pain and Restore Function
Jarred Kaiser, PhD
Emory University
Intervertebral Disc and Facet Joint Crosstalk During Spinal Degeneration
Sarah Gullbrand, PhD
University of Pennsylvania
Workshop: The Role of The Immune System in Tendon Disease
This Session is being recorded and will be available on the ORS 2023 Annual Meeting Virtual Platform following the live session.
Organizers:
Anne Gingery, PhD and Neal Millar, MD, PhD
The immune system, both systemic and locally, has been increasingly found to play an important role in tendon disorders. However there remains much debate in the musculoskeletal community of the relevant hierarchy of the immune system in tendon pathogenesis. The workshop aims to bridge the current knowledge gaps in the MSK and tendon communities and highlight the key molecular/immunological techniques that have been used over the past decade to dissect a key role of the immune system in tendon diseases that is currently being translated into novel immune mediated therapeutics in tendon pathologies.
Speakers:
Immune Environment in Normal Tendon
Sarah Snelling, DPhil
University of Oxford
The Role of Inflammatory Mediators in Tendon Healing
Stephanie Dakin, PhD
University of Oxford
The Immunology of Tendon Repair
Alayna Loiselle, PhD
University of Rochester Medical Center
The Immunobiology of Tendinopathy and Lessons From the Enthesis
Moeed Akbar, PhD
University of Glasgow
Workshop: The Utility of Quantitative MRI in ACL Surgery Postoperative Management
This Session is being recorded and will be available on the ORS 2023 Annual Meeting Virtual Platform following the live session.
Organizers:
Ata Kiapour, PhD and Braden Fleming, PhD
Quantitative magnetic resonance imaging (qMRI) has shown promises in direct non-invasive assessment of surgically treated ACL structural properties. However, there is significant knowledge gap in technical challenges and clinical benefits of incorporating qMRI as part of postoperative management of patients with ACL injury. The current workshop will discuss the current state of the art in qMRI assessment of healing ACL/graft structure as well as promises and challenges in using qMRI as a return-to-sports criteria. We hope to stimulate multidisciplinary discussion and brainstorming focused on establishing a roadmap to translate qMRI into clinic to assist with postoperative management of patients with ACL injuries.
Speakers:
qMRI Evaluation of Healing ACL: Promises and Challenges
Ata Kiapour, PhD
Boston Children’s Hospital and Harvard Medical School
qMRI as a Clinical Tool to Track ACL Healing After Surgery
Kurt Spindler, MD
Cleveland Clinic
qMRI Application in ACL Injury Risk Prediction and Return to Sports Clearance
Sandra Shultz, PhD, ATC
North Carolina Greensboro
Workshop: Advanced Techniques to Image Musculoskeletal Tissue and its Microenvironment via Multiphoton Microscopy
This Session is being recorded and will be available on the ORS 2023 Annual Meeting Virtual Platform following the live session.
Organizers:
Xinping Zhang, PhD and Edward Brown, PhD
In vivo imaging is essential due to the fact that the dynamic behavior of cells is influenced by a complex in vivo microenvironment that consists of diverse cellular components, biological factors, cytokines and growth factor gradients. In vitro or ex vivo settings cannot fully replicate what happens in vivo. Multiphoton microscopy as a superior in vivo imaging modality has been underutilized in orthopaedic research. Through this workshop, we expect to raise the interests and awareness of this technology and further promote its use in orthopaedic research. Through this workshop we expect to achieve the following learning objectives: 1. Acquire a better understanding of the technology by which stem/progenitor cells and their surrounding microenvironment can be visualized and analyzed under both physiological and pathological conditions. 2. Acquire an understanding of experimental models for study of skeletal tissue during homeostasis and regeneration. 3. Learn about the available advanced optical techniques as a means to stimulate new research avenues and develop new collaborative studies.
Speakers:
Overview of Multiphoton Excited Fluorescence, Second Harmonic Generation, and Lifetime Methods
Edward Brown, PhD
University of Rochester
Imaging Bone Tissue Vascularization and Bone Healing Microenvironment via Multiphoton Microscopy
Xinping Zhang, PhD
University of Rochester
In Vivo Imaging, Sensing, and Micromanipulation of Bone Tissue
Charles Lin, PhD
Harvard University
Workshop: Implementing the 3R Principles in Fracture Healing Research: in vitro, in silico and Refined in vivo Models
This Session is being recorded and will be available on the ORS 2023 Annual Meeting Virtual Platform following the live session.
ORS International Section for Fracture Repair
Organizers:
Melanie Haffner-Luntzer, PhD and, Katherine Hixon, PhD
Bone fracture healing is a tightly regulated process involving many cell types, mediators, and signaling pathways and is still not well understood. For successful bone regeneration, biological but also biomechanical factors play an important role. Because of this complexity, bone healing was mainly studied in animal models for decades. However, there is a strong ethical need to implement the 3R principles (replacement, reduction, refinement) into animal experiments. Therefore, this workshop will focus on existing ex vivo and in silico models to study bone regeneration. Further, strategies to refine in vivo animal models will be discussed.
Speakers:
Ex Vivo Chorioallantoic Membrane Assay and the Ex Vivo Organotypic Culture for Bone Regeneration
Richard Oreffo, DPhil DSc
University of Southampton
In Silico Models for Outcome Assessment in Bone Healing Research
Hannah Dailey, PhD
Lehigh University
Refining Animal Experiments: Pain Assessment and Management in Mouse Femoral Fracture Models
Annemarie Lang, DVM, PhD
University of Pennsylvania
Workshop: Leveraging Multidisciplinary Expertise to Identify Patients at Risk for OA after Meniscal Surgery
This Session is being recorded and will be available on the ORS 2023 Annual Meeting Virtual Platform following the live session.
Organizers:
Scott Rodeo, MD and Suzanne Maher, PhD
Our workshop will review multidisciplinary advances in in vitro, in silico, cadaveric and clinical studies, which are being used to identify mechanobiological factors related to OA development, with a specific focus on how the joint changes after meniscal surgery.
Speakers:
Biological Aspects of the Pathogenesis of OA
Robert Brophy, MD
Washington University
Imaging Joint Changes
Matthew Koff, PhD
Hospital for Special Surgery
Statistically Augmented Computational Models
Amy Lerner, PhD
University of Rochester
Mechanical Aspects of the Pathogenesis of OA
Suzanne Maher, PhD
Hospital for Special Surgery
Surgical/Anatomical Considerations, Innovations and Dilemmas – How We Are Leveraging This Data
Scott Rodeo, MD
Hospital for Special Surgery
3:15 PM – 4:15 PM
Spotlight: Tendon Development, Differentiation and Healing (featuring Alice Huang)
Spotlight: Drug Delivery to Joints (featuring Ambika Bajpayee)
Clinical Outcomes in Hip and Knee Arthroplasty
Hand and Wrist – Biomechanics
Translational and Clinical Imaging
Orthopaedic Infection and Management
4:30 PM – 5: 30 PM
ORS Career Development Committee and ORS Women’s Leadership Forum
Organizers:
Megan Killian, Ani Ural, Sarah Greising, Andrew Kuntz, Karen Troy, Meghan McGee Lawrence
The feeling of inclusion is critical for retention and success, especially for women. Inclusion can be fostered with shared habits, such as writing productivity and accountability, through
programs that offer peer mentoring. This session will include perspectives from a panel of ORS members who have experience in accountability groups, such as formal peer mentoring programs (i.e., Faculty Success Program via National Center for Faculty Development and Diversity) and informal groups (i.e., based on “Every Other Thursday”).
ORS Industry Alliance Committee and ORS Innovation Network
Over the past decade, the postgraduate-training career landscape has been dramatically changing with unique opportunities in industry, ranging from R&D in mainstream biotech sector, to consulting, startup and VC firms. This workshop brings together a diverse panel of speakers with successful non-academic careers discussing career opportunities from different perspectives.
ORS Public Outreach Committee
Organizers:
Michael Friedman, Donna Pacicca
Science advocacy can have a huge impact on government policies that affect the scientific community and the public at large. The government makes many policy decisions that impact funding for scientific research and healthcare options for patients. These decisions are often made with little or no input from the scientific community. By becoming advocates for science, we the scientific community can have a greater impact on government decisions that affect researchers and patients. This session will introduce science advocacy, inform attendees about what policy decisions governments make that impact research funding and healthcare, and identify ways for attendees to get more involved as advocates for science.
4:30 PM – 6:00 PM
Moving the Concept of Bone Tissue Quality to the Clinic
Organizers:
Jeff Nyman, PhD, Chris Hernandez, PhD
The goal of this RIG is to discuss how the quality of a person’s bone tissue can be clinically assessed in a way that adds value to the current diagnosis of osteoporosis. Participants will learn about the determinants of bone’s ability to resist fracture, how current clinical practice (DXA and FRAX) fall short in accurately predicting a patient’s fracture risk, the difference between bone toughness and bone strength, recent advances in the translation of laboratory-based measurements of bone quality to the clinic, and the importance of the organic matrix to whether an individual is at risk of a fragility fracture. The speakers have a background in mechanics of materials and will be encouraged to convey concepts for a general audience that includes biologists and clinicians.
Speakers:
Determinants of Bone’s Resistance to Fracture
Chelsea Heveran, PhD
Montana State University
Contribution of Collagen Impairment to a Loss in Bone Toughness
Claire Acevedo, PhD
University of Utah
Mechanisms of Bone Fracture Toughness in Brittle Bone Disease
Alessandra Carriero, PhD
The City College of New York
Translatable Methods to Measure Bound and Pore Water in Bone
Rachel Suowiec, PhD
Indiana University
From Basic Stem Cell Biology to Regenerative Therapies in Orthopedics
Organizers:
Wan-Ju Li, PhD, Naoki Nakayama, PhD, Johnny Huard, PhD
Stem cells are a key player in tissue development and regenerative medicine applications; therefore, to understand musculoskeletal development and diseases and harness the potential of stem cells for orthopedic therapies, it is crucial for ORS members to share their latest findings and knowledge of stem cell research in the community of orthopedics. The purposes of this symposium are 1) to bring researchers together to form the research interest group of stem cells and musculoskeletal regenerative medicine, 2) to create a platform for stem cell scientists in ORS to share their research findings and collaborate on projects, and 3) to serve as an educational occasion for ORS members learning the latest knowledge and development of stem cell research and their applications in orthopedics.
In vitro embryology using pluripotent stem cells for cartilage tissue engineering
Naoki Nakayama, PhD
Steadman Philippon Research Institute
Epigenetic regulation of stem cell renewal and differentiation
Nidhi Bhutani, PhD
Stanford University
Cell therapy for augmentation of rotator cuff tendon healing
Scott Rodeo, MD
Hospital for Special Surgery
Understanding the Role of Multi-organ Crosstalk in Knee Joint Health, Disease and Repair
Organizers:
Isabel Amado, Thomas Hodgkinson, PhD, Farshid Guilak, PhD
The Multi-Organ System Crosstalk RIG will advance the science underpinning knee joint care by promoting communication and fostering collaborations among individuals interested in knee joint science. The purpose is to serve as a network to facilitate the interaction between basic scientists, translational researchers, and clinicians interested in collaborating on studies of multi-organ system crosstalk science.
This session will specifically focus on the multi-organ crosstalk in knee joint health, disease and repair from the molecular and biomechanics point of view, in order to understand better the mechanisms of disease and the development of new treatments for joint repair is needed for the following reasons: 1) the wide spectrum of pathology and related treatments; 2) the complex multi-organ nature of the joints; 3) ongoing challenges in the treatment of multifactorial joint conditions.
Discussion around these four topics is expected to ultimately lead to the improvement of clinical treatment of the knee joints.
Speakers:
Leveraging tendon developmental mechanisms for treatment strategies
Catherine Kuo, PhD
University of Maryland
Role in fat in Osteoarthritis
Kelsey Collins, PhD
Washington University in St. Louis
A role for osteocytes in post-traumatic and age-associated osteoarthritis
Tamara Alliston, PhD
University of California San Francisco
Workshop: Ankle Osteoarthritis: Toward New Understanding and Opportunities for Intervention
This Session is being recorded and will be available on the ORS 2023 Annual Meeting Virtual Platform following the live session.
Organizer:
Cesar de Cesar Netto, MD, PhD and William Ledoux, PhD
It is commonly understood that the ankle infrequently develops primary osteoarthritis (OA), especially when compared to the hip and the knee. While this is true, the consequences of end-stage ankle OA can nonetheless be extremely debilitating, with associated impairment comparable to that associated with end-stage kidney disease or congestive heart failure. Ankle OA generally develops following trauma. Recent evidence suggests that ankle OA can develop more often than previously appreciated after “simple” rotational ankle fractures and chronic instability associated with recurrent ankle sprains. The mechanisms whereby post-traumatic ankle OA develops are not entirely understood, but mechanical factors are implicated. A better understanding of the prevalence and mechanical etiology of ankle OA will lead to better prevention and mitigation of post-traumatic ankle OA. New technologies, including weight bearing CT, dual video fluoroscopy and needle arthroscopy offer fresh opportunities to better understand the relationships between trauma, residual ankle instability, OA development and foot/ankle function. New conservative and surgical interventions, including custom carbon fiber bracing, improved fracture fixation, and ligamentous repair, hold promise for improving treatment that may prevent residual ankle instability and the development of post-traumatic ankle OA, but studies are needed to fill in key knowledge gaps here related to etiology so that the interventions can target key factors. (ORS Foot and Ankle RIG & American Orthopedic Foot and Ankle Society (AOFAS) & International Weight Bearing CT Society (IWBCTS).
Speakers:
Enabling Technologies for Measuring Deformity to Inform New Interventions to Treat Ankle OA
Amy Lenz, PhD
University of Utah
A Role for Custom Carbon Fiber Bracing in the Prevention of Post-Traumatic Ankle OA
Jason Wilken, PT, PhD
University of Iowa
Operatively Treating Ankle Instability to Prevent Post-Traumatic OA
Mark Easley, MD
Duke University
5:30 PM – 7:00 PM
Join us in the Exhibit & Poster Hall for a Poster Reception.
8:00 AM – 9:00 AM
Cartilage and Synovium – Mechanotransduction
Clinical Research – Methods II
Spotlight: Tendon and Ligament Mechanobiology (featuring Michael Kjaer)
Tumors – Genetics, Primary and Metastatic
Computational Modeling in Arthroplasty
Spine – Therapies and Diagnostics
9:15 AM – 10:15 AM
Authors will be available at ODD numbered posters.
10:30 AM – 12:00 PM
This Session will Live Stream on the ORS 2023 Annual Meeting Virtual Platform.
Incoming Presidential Address
Kurt D. Hankenson, DVM, PhD, Incoming President
ORS Presidential Inauguration & Address
ORS Debate: Orthopaedic Research Needs More Discovery v Hypothesis Driven Science
Moderator
Anne-Marie Malfait, MD, PhD, Rush University
For the Motion
Chris Hernandez, PhD, Cornell University
Against the Motion
Frank Beier, PhD, University of Western Ontario
12:15 PM – 1:15 PM
Biomaterials – Disc and Osteoarthritis
Knee – Imaging, Traumatic Joint Injury and OA Assessment
Late Breaking Session
Bone – Diseases and Disorders
Biology of Shoulder Injury and Regeneration
Robotics and Technology in Arthroplasty
1:30 PM – 2:15 PM
This Session will Live Stream on the ORS 2023 Annual Meeting Virtual Platform.
