Research Interest Groups (RIGs) facilitate the thoughtful exchange of ideas within the global, multi-disciplinary community of the ORS. They provide opportunities for engaging in informative, transformative, and live discussions with colleagues in specific areas of musculoskeletal research, whether it be basic, applied, clinical, and/or orthopaedic. To explore content that complements or differs from the ORS Annual Meeting, RIGs are encouraged to focus on unique approaches, methodologies, diseases, or connections that inspire brainstorming across our multi-disciplinary groups

Saturday, February 3

7:00 pm – 8:30 pm

Organizers: Sonia Bansal, PhD, John Drazan, PhD, Lauren Heckleman, PhD, Amy Loya, PhD, Jason Marvin, PhD, Christopher Panebianco, PhD

Academic career paths are more than research. To advance in the field of orthopaedics, researchers must also complete scholarly activities like teaching, mentorship, and outreach. The goal of this RIG is to teach members of the ORS community how they can re-envision their teaching activities as forms of scholarship. Specifically, we will discuss how to conduct and publish educational research, and how to write about teaching activities for academic promotion.

The ORS Education RIG – Current Goals and the Path Forward
Sonia Bansal, PhD, Duke University

Aligning Interests and Expectations: Undergraduate Research at an R1 Institution
Spencer Szczesny, PhD, Penn State University

Teaching and Outreach in a Biomedical Engineering Department
Ed Guo, PhD, Columbia University

7:00 pm – 8:30 pm

Organizers: Woojin Han, PhD, Young C. Jang, PhD

Skeletal muscle plays a crucial role in musculoskeletal health and regeneration. With age, skeletal muscles undergo significant changes, including a decrease in mass, strength, and regenerative capacity, all of which can have substantial implications for mobility and overall quality of life. These alterations are often linked to common orthopaedic conditions such as osteoporosis, osteoarthritis, and tendon, ligament disorders, making them a central focus in therapeutic interventions. The RIG (Research Interest Group) session’s specific emphasis on aging skeletal muscle stem cell biology and niche will help to deepen the understanding of these changes and potentially lead to the development of treatments that can mitigate or reverse the negative impacts of muscle aging. This knowledge is vital for improving patient care and outcomes in an aging population, where musculoskeletal disorders are increasingly prevalent.

Programming and reprogramming stem cells in aging biology
Amy Wagers, PhD, Harvard University

The changing mechanical niche of muscle stem cells during aging
Chen-Ming Fan, PhD, Carnegie Institution for Science & Johns Hopkins University

7:00 pm – 8:30 pm

Organizers: Arin Oestreich, PhD and Rachel Miller, PhD

Osteoarthritis (OA) is a heterogeneous disease involving multiple organ systems which influence disease development and progression. This complexity requires an interdisciplinary approach to address the substantial challenges for developing new solutions to treat and prevent OA. The goal of this program is to leverage interdisciplinary strengths to stimulate and propose new strategic scientific approaches that exist at the interface between disciplines. The discussion theme will focus on the cumulative effect of adverse events throughout the lifespan that increase the risk for OA to devise targeted preclinical treatment strategies to slow or prevent disease progression. This interdisciplinary consortium will bring together experts from different training backgrounds to discuss critical molecular and mechanical drivers of disease. Finally, this group will provide an opportunity for basic and clinical researchers to discuss innovative approaches to treating OA progression.

The Developmental Origins of Osteoarthritis: The Role of Maternal Diet
Arin Oestreich, PhD, Washington University

Telehealth Interventions to Promote Physical Activity in Adults with Osteoarthritis
Daniel White, PT, ScD, University of Delaware

DNA Damage and Cellular Senescence in Osteoarthritis Pathophysiology
Brian Diekman, PhD, University of North Carolina

7:00 pm – 8:30 pm

Organizers: Ling Qin, PhD and Jaimo Ahn, MD, PhD

Stem cells have long been proposed to hold great promise as a fracture healing therapeutic. However, the exact identities of those stem and progenitor cells and their regulatory pathways are still under great debate and controversy. Their interactions with the fractured environment are also not clear. This RIG invites renowned basic and clinician scientists to share the most current knowledge and state-of-the-art approaches in studying fracture healing process and stem cells contributing to this process. Our purpose is to foster a fruitful discussion among all participants to achieve consensus on the current studies, to identify the discrepancy, and to seek future research directions in bone regeneration.

Notching the Fracture
Ivo Kalajzic, MD, PhD, UConn Health

Targeting COX-2/PGE2 to Enhance Fracture Repair: EP1 Receptor Inhibition Regulates Progenitor Cells and Accelerates Bone Regeneration in Delayed Healing Models
Regis O’Keefe, MD, PhD, Washington University in St Louis

Muscle Fibroadipogenic Progenitors in Fracture Healing
Ugur Ayturk, PhD, Hospital for Special Surgery

Sunday, February 4

7:00 pm – 8:30 pm

Organizers: Sibylle Grad, Mauro Alini, Martin Stoddart, Ilse Jonkers, Rik Lories and Dr. Rocío Castro-Viñuelas

Mechanical signals are important homeostatic factors of the different musculoskeletal tissues. Furthermore, the role of mechanical signaling crosstalk between tissues is often suggested, but not well documented to contribute to disease development. Hence, this is an often-missed opportunity for identifying future therapeutic targets. In vitro set-ups that allow controlled and independent modulation of the mechanical and biological environment seem to be excellent systems to unravel the interaction between different MSK tissues. A fundamental understanding on how mechanical factors drive biological responses of the different tissues is needed e.g., for interpreting the cascade of events inducing degenerative changes to the whole joint complex, as a basis for future innovative and integrated disease modifying approaches. This RIG will focus on musculoskeletal tissue crosstalk in joint and bone mechanobiology and its role in regenerative therapies, also in the context of osteoarthritis. The RIG will feature renowned invited speakers aiming to foster the interchange of knowledge and to discuss the insights gained from new and cutting-edge in vitro bioreactor and joint-on-a chip approaches that help to understand how mechanical stimulation impacts multi-tissue signaling that underlies bone, spine and joint homeostasis and disease at cell and tissue level. At the end of the meeting, there will be time for interactive interdisciplinary discussion, brainstorming and questions. We expect participants of this RIG will work together and to define pathways to move multi-scale bone and joint mechanobiology research forward.

Omics-Based Mouse Models to Study Mechanobiology and Tissue Crosstalk During Bone Healing
Esther Wehrle, DVM, PhD, AO Research Institute Davos

Role of Multi-Tissue Crosstalk in Understanding Chronic Back Pain
Junxuan Ma, PhD, AO Research Institute Davos

Joint-on-Chip Models for Studying Mechanobiology in Joint Tissues
Marcel Karperien, University of Twente

The Role of the Synovium in Multi-Tissue Crosstalk of the Joint
Clark Hung, PhD, Columbia University

7:00 pm – 8:30 pm

Organizers: Wan-Ju Li, PhD, Naoki Nakayama, PhD, Johnny Huard, PhD

Stem cells play a crucial role in tissue development and regenerative medicine, making it essential for members of the ORS to come together and share their latest insights on stem cell research in the field of orthopedics. This symposium aims to achieve three main goals: 1. Bringing researchers together to form a research interest group focused on stem cells and musculoskeletal regenerative medicine. 2. Creating a platform for stem cell scientists within ORS to collaborate, share their research findings, and work on joint projects. 3. Providing an educational opportunity for ORS members to learn about the latest developments in stem cell research and their applications in orthopedics.

Directed Differentiation to Next Generation Orthopedic Deliverables
April Craft, PhD, Boston Children’s Hospital

Enhanced Bone Healing Using Genetically Modified MSCs
Stuart Goodman, MD, PhD, Stanford University

Novel GMP-Grade Pluripotent Stem Cell-Derived Implant for Articular Cartilage Repair. Hope and Challenges
Denis Evseenko, MD, PhD, University of Southern California

SMART Stem Cells for Orthopedic Applications
Johnny Huard, PhD, Steadman Philippon Research Institute

7:00 pm – 8:30 pm

Organizers: William Ledoux, PhD, L Daniel Latt, MD, PhD, Amy Lenz, PhD, and Karen Kruger, PhD

The Foot and Ankle RIG will advance the science underpinning foot and ankle care by promoting communication and fostering collaborations among individuals interested in foot and ankle science. The purpose is to serve as a network to facilitate the interaction between basic scientists, translational researchers, and clinicians interested in collaborating on studies of foot and ankle science. An RIG session specifically focusing on the biomechanics, outcomes and conditions of the foot and ankle is needed for four reasons: 1) the wide spectrum of pathology and related treatments; 2) the complex anatomy of the foot and ankle; 3) a paucity of biomechanical data; and 4) ongoing challenges in making adequate diagnoses. Discussion around these four topics is expected to ultimately lead to the improvement of clinical care of the foot and ankle patient population.

How Imaging, Analyzing, and Modeling in 3D is Changing Diagnosis and Treatment of Alignment Disorders of the Foot
Cesar de Cesar Netto, MD, PhD, Duke University

Standardizing Terminology, 3D Spatial Orientation, and Relative Positioning of the Foot and Ankle Bones: An Expert Consensus Task Force
Karen Kruger, PhD, Marquette University and Amy Lenz, PhD, University of Utah

Monday, February 5

7:00 pm – 8:00 pm

Organizers: Daniel Grande, PhD and Shane Shapiro, MD

The field of regenerative medicine is a rapidly evolving area of research with many unknowns that need to be resolved. Our goal is to educate the ORS community and apply evidence based medicine standards to this new and emerging field closely allied with the interests of the ORS.

Overview of Orthobiologics
Dmitriy Sheyn, PhD, Cedars-Sinai Medical Center

The BARB and its Goals for Defining the Efficacy of Orthobiologic Therapies
Daniel Grande, PhD, Northwell Health

Clinical Stem Cell Use: Fact or Fiction
Constance Chu, MD, Stanford University

PRP and its Potential /Use in Sports Medicine Injuries
Scott Rodeo, MD, Hospital for Special Surgery

7:00 pm – 8:30 pm

Organizers: Jeffry Nyman, PhD, Christopher Hernandez, PhD and Rachel Surowiec PhD

Current effective interventions to enhance bone health focus on increasing bone mass or bone mineral density (BMD) in people clinically diagnosed with osteoporosis. However, up to half of fragility fractures occur in individuals with a BMD that does not qualify as osteoporosis. Age- and disease-related increases in the risk of these fragility fractures are often unexplained by low BMD. As new research identifies biological and material mechanisms responsible for fragility fractures, we must accelerate translation of this research to develop urgently needed diagnostics and therapeutics to fill the fragility gap in aging and obesity. The purpose of this RIG is to identify biological and physicochemical drivers of bone fragility that can be clinically assessed AND targeted to improve bone health. Doing so recognizes the importance of the extracellular matrix and its hierarchical organization to the fracture resistance of bone.

Targeting Biological Pathways to Protect or Improve Bone Quality
Tamara Alliston, PhD, University of California San Francisco

Quantifying Bone Fracture at the Nanoscale: Mineralized Collagen Fibrils and Their Interactions
Ottman Tertuliano, PhD, University of Pennsylvania

Raman Spectroscopy for Bone Quality Assessment – Are We There Yet?
Hani Awad, PhD, University of Rochester

MRI Measurements of Bound Water and Pore Water as Clinical Markers of Bone Quality
Mark Does, PhD, Vanderbilt University

7:00 pm – 8:30 pm

Organizers: Alberto Carli, MD and Dustin Williams, PhD

Musculoskeletal infections present multifaceted challenges in orthopedics, requiring integration of clinical expertise, cutting-edge research, and innovative solutions. This session aims to highlight critical clinical concerns, reveal the forefront of research, and discuss the avenues of funding. This session will also bridge this gap by uniting clinicians, researchers, and potential investment strategies for an interdisciplinary dialogue through three unique panel title discussions.

A Non-Invasive Approach for Biofilm Reduction on Metallic Implants: How to Move New Technologies into the Clinic
Dave Greenberg, MD, UT Southwestern/Solenic Medical

DoD Funding Mechanisms and Considerations (e.g., differentiation from NIH) with Emphasis on MTEC Process and Focus
Dave Hood, Medical Technology Enterprise Consortium (MTEC)

An Industry Perspective on Anti-Infection Product Development: Challenges and Opportunities
Dave Armbruster, MS, DePuy Synthes

Current State of Open Fracture-Related Infection and Purgo Pouch Technology—A Breakthrough Device
Dave Rothberg, MD, University of Utah/Purgo Scientific