*Agenda subject to change.

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Monday, September 5, 2022

2:00 PM – 5:00 PM
ORS ISFR Section Officer Meeting

5:00 PM – 6:15 PM
Walking Tour of City & University (optional)

7:30 PM – 9:00 PM
Trainee and Mentor Networking: Scientific Team Building

Tuesday, September 6, 2022

7:00 AM – 10:00 AM
Registration      

8:00 AM – 8:15 AM
Presidential Address & Welcome
Chelsea Bahney, PhD
Steadman Philippon Research Inst.
University of California, San Fran

8:15 AM – 9:30 AM
Mechanobiology: What is Known and Barriers to Translation

Discussion Leaders:
Georg Duda, PhD
Berlin Institute of Health, Charité

Peter Augat, PhD
Paracelsus Medical University

8:20 AM – 8:30 AM
Clinical Considerations and Options for Mechanical Fixation
John Keating, MD
University of Edinburgh

8:30 AM – 8:40 AM
Towards Controlling Mechanobiology in Bone Regeneration
Georg Duda, PhD
Berlin Institute of Health, Charité

8:40 AM – 8:50 AM
Innovations in Engineering Mechanobiology
Viola Vogel, PhD
ETH Zurich

8:50 AM – 9:00 AM
Commercial Perspective: Opportunities and Challenges for Translation
Hannah Dailey, PhD
Lehigh University
OrthoXel

9:00 AM – 9:30 AM
Moderated Discussion  

10-Minute Break 

9:40 AM – 10:30 PM
ISFR Podium Session I: Novel Therapeutic Approaches

Session Moderators:
Elizabeth Rosado Balmayor, PhD
RWTH Aachen University Hospital

Matt Silva, PhD
Washington University in St. Louis

9:40 AM – 9:50 AM
Early Physical Rehabilitation Following Disuse Induced Fracture Increases Callus Bone Formation via Increased Chondrogenesis and Decreased Resorption
Evan Buettmann
Virginia Commonwealth University

9:50 AM – 10:00 AM
Dysregulated Energy Production Impact the Outcome of Scaffold-Guided Bone Regeneration in Type 2 Diabetes
Daniela Sofia Dias
Julius Wolff Institute, Berlin

10:00 AM – 10:10 AM
The Accordion Technique Does Not Improve Healing Compared to Conventional Distraction Osteogenesis
David Bertrand
McGill University

10:10 AM – 10:20 AM
Engineered Platform for Localized mRNA Delivery in Fracture Repair
Anna Laura Nelson
Steadman Philippon Research Institute
Colorado State University

10:20 AM – 10:30 AM
MicroRNAs and Their Role in Fracture Healing: Comparing Different Surgical Treatment Strategies
Rald Groven
MERLN, Maastricht University

15-Minute Break

10:45 AM – 11:40 AM
ISFR Podium Session II: Progenitor Cells and Inflammation in Murine Models of Fracture Repair

Session Moderators:
Clare Yellowley, PhD
University of California, Davis

Johnny Huard, PhD
Steadman Philippon Research Institute

10:45 AM – 10:55 AM
A Novel Mouse Model Reveals the Essential Role of Osteoblast Proliferation for Fracture Healing
Matt Silva, PhD
Washington University in St. Louis

10:55 AM – 11:05 AM
The Epigenetic Enhancer Landscape Determines the Endogenous Osteochondral Potential of Stromal Cells Depending on their Tissue Origin
Sven Geissler, PhD
Berlin Institute of Health, Charité

11:05 AM – 11:15 AM
Mast cells critically regulate trauma-induced inflammation and compromised bone repair
Verena Fisher, PhD
Ulm University

11:15 AM – 11:25 AM
Genetic Model of Accelerated Aging Induces Elevated Systemic Senescence and Delayed Fracture Repair
Victoria Duke
Steadman Philippon Research Inst.

11:25 AM – 11:35 AM
Altered local and systemic expression of inflammatory and neuro-endocrine markers in fracture patients with high psychosocial stress scores
Melanie Haffner-Luntzer, PhD
Ulm University

11:40 PM – 1:00 PM
Poster Competition & Diversity Session

Poster Chairs:
Melanie Haffner-Luntzer,
Elizabeth Rosado Balmayor

1:00 PM – 2:15 PM
Personalized Regenerative Therapy: Unmet Needs & Future Directions

Discussion Leaders:
Melanie Haffner-Luntzer, PhD
Ulm University

Kurt Hankenson, PhD
University of Michigan

1:05 PM – 1:15 PM
Clinical State of the Art: Targeting Personalized Immune Competence
Sven Geissler, PhD
Berlin Institute of Health, Charité

1:15 PM – 1:25 PM
Good vibrations: Fracture treatment in osteoporotic mice
Anita Ignatius, PhD
Ulm University

1:25 PM – 1:35 PM
Innovation: Bone-on-a-Chip
Daniel Kelly, PhD
Trinity College Dublin

1:35 PM – 1:45 PM
Clinical Trials in Personalized Orthobiologics
Johnny Huard, PhD
Steadman Philippon Research Institute

1:45 PM – 2:15 PM
Moderated Discussion  

15-Minute Break 

2:30 PM – 3:45 PM
ISFR Podium Session III: Clinical Studies in Bone Repair

Session Moderators:
Francis Lee, MD
Yale

Ines Reichert, FRCS MD, PhD
King’s College Hospital London

2:35 PM – 2:45 PM
Advancing the Quest for Validated Biomarkers of Fracture Repair
Zachary Working, MD
Oregon Health Science University

2:45 PM – 2:55 PM
High rates of Imminent Subsequent Fracture after Femoral Neck Fracture: A global review documenting infrequent intervention to prevent a subsequent fracture in high-risk hip fracture patients
Emil Schemitsch, MD
London Health Sciences Centre

2:55 PM – 3:05 PM
The value of sonication in the differential diagnosis of septic and aseptic non-union in comparison to tissue culture and histopathology
Katharina Trenkwalder, MD
Paracelsus Medical University

3:05 PM – 3:15 PM
Assessing the Effect of Lateral Locking Plate Working Length on Strain for Distal Femur Fractures
Gregory Roytman, DC
Yale

3:15 PM – 3:45 PM
Clinical Trial: Sliding-Docking Ilizarov Apparatus in Treatment of Infected Critical-Sized Bone Defect of Tibia
Zixiang Li, MD
Shanghai Jiaotong University

15-Minute Break

4:00 PM – 4:30 PM
Invited Keynote:
Side Effects of the Pandemic: How COVID Spurred Innovation and Brought Scientists Together

Melanie Ott, PhD
Gladstone Institute, UCSF
Chan Zuckerberg BioHub

4:30 PM – 5:30 PM*
Innovation Toolbox: Concept to Commercialization

Session Moderators:
Roland Herzog, Dr. sc. Nat
AO Innovation Translation Center

Hannah Daily, PhD
OrthoXel & Lehigh University

4:30 PM – 4:45 PM
Clinician Innovators: Designing Solutions to Address Clinical Need and Evaluating Commercial Opportunity
Marc Philippon, MD
The Steadman Clinic & SPRI

4:45 PM – 5:00 PM
EU and UK medical device regulations: What’s changing?
Joseph Langley
EU Medical Device Regulation

5:00 PM – 5:15 PM
From the Idea Stage to Commercial Launch: How to Finance Your adVenture (VIRTUAL)
Emanuele Chisari, MD
Rothman Orthopaedic Institute Chief Medical Officer, Parvizi

5:15 PM – 5:30 PM
How to Craft the Perfect Pitch
Roland Herzog, Dr. sc. Nat
AO Innovation Translation Center

5:20 PM – 5:30 PM
How to Craft the Perfect Pitch
Suzanne Tabbaa
SimplexBio

*Unmet needs will be built into a survey for prior to the meeting and include the ORS/OTA Symposium on Unmet Needs in Orthopaedic Trauma. Coordinated by Chelsea Bahney, Meghan Moran, and Dan Youngstrom

5:45 PM – 7:00 PM
Awards & Networking Reception
University of Edinburgh

7:30 PM – 10:00 PM
ISFR Banquet Dinner
New Club

Wednesday, September 7, 2022

7:30 AM – 10:00 AM
Registration   

8:15 AM – 8:30 AM
Welcome to ISFR-OTS Clinical Bridge Sessions
Andrew Duckworth, PhD
University of Edinburgh

8:30AM – 9:00 AM
ORS ISFR Presidential Guest 
Collaborative Musculoskeletal Research Networks: Creating an Impact on Patient Care Worldwide
Ted Miclau, MD
Zuckerberg San Francisco General
University of California, San Fran

9:10 AM – 10:15 AM
ISFR/OTS Clinical Bridge Session – Managing Bone Loss

Discussion Leaders:
Andrew Duckworth, PhD
University of Edinburgh

Prism Schneider, MD
University of Calgary

9:10 AM – 9:20 AM
Invited Speaker 1 – Novel Approaches
Mike Kelly, MD
North Bristol Trust

9:20 AM – 9:30 AM
Invited Speaker 2 – Frames
Ben Ollivere, MD
University of Nottingham

9:30 AM – 9:40 AM
Invited Speaker 3 – Biomaterials Revisited: New Insights
Chris Arts, PhD
Maastricht University

9:40 AM – 9:50 AM
Invited Speaker 4 – Next Generation Tissue Engineering
Kent Leach, PhD
University of California, Davis

9:50 AM – 10:15 AM
Moderated Discussion  

15-Minute Break

10:30 AM – 12:00 PM
ISFR/OTS Bridge Session – Open Fractures & Infection

Discussion Leaders:
Francis Lee, MD
Yale

Jerry Tsang, MD
University of Edinburgh

10:30 AM – 10:40 AM
Invited Speaker 1 – Current Guidance
Mike Kelly, MD
North Bristol Trust

10:40 AM – 10:50 AM
Invited Speaker 2 – How Do I Do It?
Ben Ollivere, MD
University of Nottingham

10:50 AM – 11:10 AM
Invited Speaker 3 – Impaired fracture healing by Staphylococcus aurues
Francis Lee, MD
Yale

11:20 AM – 11:30 AM
Invited Speaker 4 – Translational Therapies
Fintan Moriarty, MD
AO Research Institute

11:30 PM – 12:00 PM
Moderated Discussion  

12:00 PM – 1:30 PM**
Poster Walking Tour

Poster Chairs:
Melanie Haffner-Luntzer
Elizabeth Rosado Balmayor

1:30 PM – 3:00 PM
ISFR/OTS – Clinical Bridge Session Osteoporotic Fractures

Discussion Leaders:
Chloe Scott, MD
Edinburgh Orthopaedics

Anita Ignatius, PhD
Ulm University

1:30 PM – 1:40 PM
Invited Speaker 1 – Role of Non-Operative
Andrew Duckworth, MD
University of Edinburgh

1:40 PM – 1:50 PM
Invited Speaker 2 – Role of Surgery
Tim White, MD
Edinburgh Orthopaedics

1:50 PM – 2:00 PM
Invited Speaker 3 – Biomechanics
Pankaj Pankaj, MD
University of Edinburgh

2:00 PM – 2:10 PM
Invited Speaker 4 – Osteoanabolic Therapies
Prism Schneider, MD
University of Calgary

2:10 PM – 3:00 PM
Moderated Discussion  

3:00 PM – 4:00 PM
Recognitions, Closing Remarks, Past-President Lectures and ISFR Presidential Handover
Hamish Simpson, MD
University of Edinburgh

As a reminder, the Biennial ORS ISFR Meeting will be held prior to the International Combined Orthopaedic Research Societies (ICORS) 30th Anniversary World Congress, September 7th has been designed as a clinical bridge day where both ISFR and ICORS members can attend so click here to register now to attend the (ICORS) 30th Anniversary World Congress!