Coordinated by the ORS Basic Science Education CommitteeOn the Horizon presents brief articles discussing current scientific investigations that may have future orthopaedic clinical applications.

This feature is presented quarterly in the Journal of the American Academy of Orthopaedic Surgeons (January, April, July, and October).

Please read and enjoy the following articles.

Click the title to read article.

April 2018

Targeting Osteogenesis-Angiogenesis Coupling for Bone Repair

January 2018

Arthritis Gene Therapy Approved in Korea

December 2017

Mysteries Behind the Cellular Content of Tendon Tissues

July 2017

Biophysics Rules the Cell Culture but Has Yet to Reach the Clinic: Why Is That?

April 2017

Mechanical Signals as Regulators or Cartilage Degeneration and Regeneration

January 2017

The Meniscus

October 2016

Future Treatment Strategies for Delayed Bone Healing: An Osteoimmunologic Approach

July 2016

Reverse Dynamization: A Novel Approach to Bone Healing

April 2016

Role of Subchondral Bone in Articular Cartilage Degeneration and Repair

January 2016

Using Mathematical Modeling to Design Effective Regenerative Medicine Strategies for Orthopaedics

October 2015

Emerging Concepts in Gene Therapy for Osteoarthritis

Frontiers in Medical Device Design: An Approach for Making Arthroplasty Affordable Globally

July 2015

Mesenchymal Stem Cells as a Source of Repair Cytokines: Mesenchymal Stem Cells as the Conductor

April 2015

Endogenous Cell Homing for Intervertebral Disk Regeneration

January 2015

Wnt Signaling: An Emerging Target for Bone Regeneration

October 2014

Biomaterials for Cartilage Regeneration

Optimizing BMP-2-induced bone repair with FGF-2

July 2014

Mechanical Loading: Potential Preventive and Therapeutic Strategy for Osteoarthritis

Recent Progress in Osteoarthritis Research

April 2014

Musculoskeletal Modeling for Hip Replacement Outcomes Analyses and Other Applications

January 2014

Optimizing Stem Cell Engineering for Orthopaedic Applications

October 2013

Update on Biologics in the Treatment of Rotator Cuff Disease

Serum Biomarkers as Predictors of Stage of Work-related Musculoskeletal Disorders

July 2013

Using Computational Simulation for Analysis and Development of Next-generation Orthopaedic Devices

How Do Statistical Differences in Matrix-sensitive Magnetic Resonance Outcomes Translate Into Clinical Assignment Rules?

April 2013

Synovial Stem Cells in Musculoskeletal Regeneration

Annexins: Novel Therapeutics Targets for the Treatment of Osteoarthritis?

January 2013

Mesenchymal Stromal Cell Transplantation in the Regeneration of Articular Cartilage & Bone Using a Magnetic Cell Delivery System

The Role of Metabolomics in Osteoarthritis Research

October 2012

Sex Differences in Osteoarthritis of the Knee

The Roles of Osteocyte Signaling in Bone

Endothelial Progenitor Cells: A Novel Cell-based Therapy in Orthopaedic Surgery

July 2012

Evolving Strategies To Prevent Implant-associated Infections

April 2012

Osteoarthritis and Metabolic Syndrome

Autophagy: A New Therapeutic Target in Cartilage Injury and Osteoarthritis

January 2012

Wnt, Osteosarcoma, and Future Therapy

Nanotechnology in Orthopaedics