ORS Musculoskeletal Biology Workshop Agenda

*Scientific Agenda subject to change.

3:00 PM – 5:30 PM
Registration Open
Primrose Lobby

7:00 PM – 10:00 PM
Networking Reception
Magpie Terrace

7:00 AM – 8:00 AM
Breakfast (provided)

8:00 AM – 8:10 AM
Welcome from the Workshop Co-Directors
Teresita Bellido (University of Arkansas for Medical Sciences) & Alex Robling (Indiana University)

8:10 AM – 9:10 AM
Welcome & Plenary Session: (RIB) Award and Presentation

The Power of 1 g:disuse bone and muscle loss
Rib Awardee: Susan Bloomfield (Texas A&M)

9:15 AM – 10:00 AM
Blue Ribbon Posters
Chair: Teresita Bellido (University of Arkansas for Medical Sciences)

10:00 AM – 10:15 AM
Break

10:15 AM – 12:00 PM
Session: Osteocytes: from Biology to Pathophysiology
Chair: Natalie Sims (University of Melbourne)

Hezekiah’s Tunnels: Development and Remodeling of the Canalicular System
Joel Boerckel (University of Pennsylvania)

Osteocytic Pericellular Tethers in Mechanosensing
Liyun Wang  (University of Delaware)

Osteocytic Control of Bone Mineralisation
Natalie Sims (University of Melbourne)

12:00 PM – 2:00 PM
Lunch (on your own)

2:00 PM – 4:00 PM
Recreation

4:00 PM – 7:00 PM
Dinner (on your own)

7:00 PM – 10:00 PM
Poster Session/Poster Reception

7:00 AM – 8:00 AM
Breakfast (provided) 

Targeted-ERT for Lysosomal Disorders of the Musculoskeletal System
Aris Economides (Regeneron) 

8:00 AM – 9:00 AM
ASBMR/Harold M. Frost Young Investigator Award Presentations
Chair: Teresita Bellido (University of Arkansas for Medical Sciences)

9:00 AM – 9:15 AM
Break

9:15 AM – 12:00 PM
Session: Autologous-Autogenous Treatments for Musculoskeletal Disease
Chair: Steven Charlebois (MED Institute)

Using Orthobiologic Tools to Treat Diseases and Injuries of the Knee
Neven Steinmetz (Regenexx)

Platelet Rich Plasma and Mesenchymal Stem Cells: Harnessing Synergistic Effects to Improve Fracture Healing
Chelsea Bahney (Steadman-Philippon Institute)

Development and Approval of Autologous Cell-Based Therapies
Lara Silverman (LIS BioConsulting, LLC)

Alice L. Jee Award Winners

12:00 PM – 1:00 PM
Lunch (on your own)

1:00 PM – 2:30 PM
Career Development Workshop: The Pandemic: Impacts, Silver Linings, and Recovery
Chairs: Marjolein van der Meulen (Cornell University) and Sherry Liu (University of Pennsylvania)

2:30 PM – 4:00 PM
Recreation

4:00 PM – 7:00 PM
Dinner (on your own)

7:30 PM – 9:30 PM
Session: Advances in Optical Imaging of Musculoskeletal Tissues
Chair: Sarah Calve (University of Colorado)

Intravital Imaging of Live Bone Cells In Vivo
Masaru Ishii (Osaka University)

Neurovascular Imaging in the Murine Calvarium
Warren Grayson (Johns Hopkins University)

Visualization of the Extracellular Matrix at Developing Tissue Interfaces
Sarah Calve (University of Colorado)

7:00 AM – 8:00 AM
Breakfast (provided)

8:00 AM – 9:00 AM
ASBMR/Harold M. Frost Young Investigator Award Presentations
Chair: Alexander Robling (Indiana University)

9:00 AM – 9:15 AM
Break

9:15 AM – 12:00 PM
Session: Novel Pathways in Immune Regulation of Bone Remodeling
Chair: Iannis E. Adamopoulos (Harvard University)

Role of the STING Pathway in Bone Homeostasis
Ellen Gravallese (Brigham and Women’s, Harvard University) 

Studies of Osteoclast Precursors in Health and Disease
Joseph Lorenzo (UConn Health)

Identification of a Vertebral Stem Cell
Matthew Greenblatt (Cornell Weill)  

The IL-23/IL-17 Axis in Bone Remodeling
Iannis Adamopoulos (Harvard University)

12:00 PM – 1:00 PM
Lunch (on your own)

1:00 PM – 2:30 PM
Career Development Workshop by and to Early-career Investigators: First Job After Training: How to Get the Job, What Works and What Does Not?
Chairs: Annemarie Lange (University of Pennsylvania) and Neha Dole (University of Arkansas for Medical Sciences)

2:30 PM – 4:00 PM
Recreation

6:00 PM – 8:00 PM
Awards and Recognition Banquet (dinner provided)

7:00 AM – 8:00 AM
Breakfast (provided)

8:00 AM – 9:00 AM
ASBMR/Harold M. Frost Young Investigator Award Presentations
Chair: Teresita Bellido, PhD (University of Arkansas for Medical Sciences)

9:00 AM – 9:15 AM
Break

9:15 AM – 12:00 PM
Session: Skeletal Aging and the Development of Senolytic Therapies
Chair: Richard F. Loeser, Jr., MD (University of North Carolina, Chapel Hill)

Joint Tissue Senescence in Osteoarthritis
Jin Han (John Hopkins) 

Targeting Cellular Senescence to Treat Age-Related Bone Loss and Frailty
Sundeep Khosla (Mayo Clinic)

NAD+ Metabolism in Bone: Crosstalk with the Wnt Pathway and Senescence
Maria Schuller Almeida (University of Arkansas for Medical Sciences)

12:00 PM – 1:00 PM
Lunch (on your own)

1:00 PM – 5:00 PM
Recreation and Dinner (on your own)

7:30 PM – 9:30 PM
Session: Mechanobiology of Musculoskeletal Tissues
Chair:  Alice Huang, PhD (Mount Sinai Hospital)

Mechanobiology in the Microbiome and Infection
Christopher Hernandez (Columbia University)

Multiscale Mechanobiology of TGF-beta Signaling in the Skeleton
Tamara Alliston (University of California, San Francisco)

Mechanobiology of Tendon Differentiation
Alice Huang (Columbia University)

Departures