ORS Musculoskeletal Biology Workshop at Sun Valley Schedule

7:00 PM – 10:00 PM
Networking Reception

With support provided by:

7:00 AM – 8:00 AM
Breakfast

8:00 AM – 8:15 AM
Welcome

8:15 AM – 9:15 AM
Plenary Session: The Remodeling in Bone (RIB) Award and Presentation
Rib Awardee:  David Burr, PhD, Indiana University School of Medicine
How Basic Science Can Result in Clinical Insights

9:30 AM – 10:00 AM
Blue Ribbon Sun Valley Posters
Chair: Teresita Bellido, PhD, Indiana University

10:15 AM – 12:00 PM
Session: Tendon Biology and Disease
Session Chair:  Alayna Loiselle, PhD, University of Rochester Medical Center

Mechanisms of Tendon Regeneration
Alice Huang, PhD, Icahn School of Medicine at Mount Sinai

Cellular Basis of Tendon Regeneration
Alayna Loiselle, PhD, University of Rochester Medical Center

Engineering Tissue Integration
Helen H. Lu, PhD, Columbia University

2:00 PM – 4:00 PM
Volleyball

7:30 PM – 8:00 PM
Blue Ribbon Sun Valley Posters
Chair: Alexander Robling, PhD, Indiana University

8:00 PM – 10:00 PM
Poster Session 

7:00 AM – 8:00 AM
Breakfast

7:30 AM – 8:00 AM
Regeneron Breakfast Session
Cracking the Code of Rare Diseases:  Understanding Mechanisms and Developing Therapies
Presenter: Aris Economides, PhD

8:00 AM – 9:00 AM
ASBMR/Harold M. Frost Young Investigator Awards Presentations
Chair: Teresita Bellido, PhD, Indiana University

9:15 AM – 12:00 PM
Session: Major Methodologies: Material Properties and Tissue Quality – State of the Art 
Chair:  David Burr, PhD, Indiana University

Introduction – What are the Physical Attributes of Bone Tissue Properties?
David Burr, PhD, Indiana University

Measuring Bone’s Structure and Mechanical Behavior at Multiple Length Scales
Elizabeth Zimmerman, PhD Shriner’s Hospital for Children

Measuring Multi-Scale Relationships Between Bone Structure, Chemistry and Function and Their Importance to Skeletal Fragility
Virginia Ferguson, PhD, University of Colorado

Does Loss and Modification of Collagenous and Non-Collagenous Proteins Affect Fracture Risk? Tools, Assays and Disease Models
Deepak Vashishth, PhD, Rensselaer Polytechnic Institute:

Reducing Fracture Risk by Acellular Manipulation of Bone Tissue Properties
David Burr, PhD, Indiana University

1:00 PM – 2:30 PM

Career Development Workshop
Career Transitions:  Planning and Negotiating for Career Advancement
Marjolein van der Meulen, PhD, Cornell University, Chair 

• Mentoring: including transition from mentee to mentor
• Resources: start up and facilities, budgets, personnel
• Personnel: staffing a lab including recruiting graduate students, technicians & staff, postdocs
• PI vs team science: maintaining your own projects and collaborating successfully
• Transition considerations and concerns: intangibles and other considerations.
• Transitions within industry

6:00 PM – 8:00 PM
Awards & Recognition Banquet

7:00 AM – 8:00 AM
Breakfast

7:30 AM – 8:00 AM
Ultragenyx Breakfast Session
Understanding Bone Remodeling in XLH:  Insight into Restoring Phosphate Homeostasis
Presenter: Javier San Martin. MD

8:00 AM – 9:00 AM
ASBMR/Harold M. Frost Young Investigator Awards Presentations
Chair: Alexander Robling, PhD, Indiana University

9:15 AM – 12:00 PM
Session: Epigenetics and Musculoskeletal Disease
Session Chair:  Regis J. O’Keefe, MD, PhD, Washington University

Brief Overview of Epigenetics
Regis J. O’Keefe, MD, PhD, Washington University

Histone Deacetylase 3 in Cartilage Development and Osteoarthritis
Jennifer J. Westendorf, PhD, Mayo Clinic:

Defining DNMT3b and Downstream Targets in the Pathogenesis of Osteoarthritis
Regis J. O’Keefe, MD, PhD, Washington University

Genome-wide DNA Methylation Changes in Mice Under Simulated Microgravity Conditions
Mario Fraga, University of Oviedo

1:00 PM – 2:30 PM
Career Development Workshop:  Bringing Discoveries to Market: Navigating the FDA
Chair: Jose Moreno, PhD, FDA

The workshop will provide the audience with an overview of the various mechanisms available to obtain FDA feedback regarding the potential regulatory pathway ahead for any products resulting from their research efforts. This information is of special interest for researches applying to the Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) funding programs, where such regulatory information can have a larger impact in the funding process.  Attendees will gain key knowledge regarding the current regulatory pathways for device, drug, biological and combination products, and the mechanisms available to present the results of their research efforts to FDA.

7:30 PM – 9:30 PM
Session: Rare Diseases of Phosphate Handling and Tissue Mineralization: Too Much or Too Little
Chair:  Javier San Martin, MD, Ultragenyx, Inc.

Introduction to Phosphate Metabolism
Javier San Martin, MD, Ultragenyx, Inc.

From Therapeutics Target Identification to Drug Development, with an Anti-FGF23 Antibody, Burosumab
Javier San Martin, Ultragenyx, Inc.

Targeting a Unique Pathophysiology for Improved Outcomes in X-linked Hypophosphatemia
Thomas Carpenter; MD, Yale University

Multiple Osteochondroma and Fibrodysplasia Ossificans Progressiva: Two Distinct Pediatric Disorders, One Common Therapeutic Target
Maurizio Pacifici, PhD Children’s Hospital of Philadelphia

7:00 AM – 8:00 AM
Breakfast

7:50 AM – 8:00 AM
ORS Membership Presentation
Presenter: Chris Hernandez, PhD

8:00 AM – 9:00 AM
ASBMR/Harold M. Frost Young Investigator Awards Presentations
Chair: Teresita Bellido, PhD, Indiana University

9:15 AM – 12:00 PM
Session: Musculoskeletal Regenerative Medicine Meets the Clinic
Chair:  Lisa Larkin, PhD, University of Michigan

Bridge Enhanced ACL Repair: from Concept to Clinical Trial
Braden Fleming, PhD, Rhode Island Hospital/Warren Alpert Medical School of Brown University

Rotator Cuff Healing: Gaps in Knowledge, Progress and Opportunities
Kathleen Derwin, PhD, Cleveland Clinic

A Tissue Engineering Approach to Repair Volumetric Muscle Loss
Lisa Larkin, PhD, University of Michigan

12:30 PM – 5:00 PM
Guided Hikes

7:30 PM – 9:30 PM
Session: Targeting Musculoskeletal Tissues
Chair:  Brendan Boyce, MD, University of Rochester Medical Center

Introduction to Targeting Strategies
Brendan Boyce, MD, University of Rochester Medical Center

Targeting Chloroquine and Hydroxychloroquine to Bone to Increase Bone Mass
Brendan Boyce, MD, University of Rochester Medical Center

Genome Engineering of New Stem Cell Therapies for Arthritis
Farshid Guilak, PhD, Washington University:

Bone-targeting Bortezomib in Pre-clinical Myeloma Studies
Lianping Xing, PhD, University of Rochester Medical Center