8:15 AM – 9:15 AM Plenary Session: The Remodeling in Bone (RIB) Award and Presentation Rib Awardee: David Burr, PhD, Indiana University School of Medicine How Basic Science Can Result in Clinical Insights
9:30 AM – 10:00 AM Blue Ribbon Sun Valley Posters Chair: Teresita Bellido, PhD, Indiana University
10:15 AM – 12:00 PM Session: Tendon Biology and Disease Session Chair: Alayna Loiselle, PhD, University of Rochester Medical Center
Mechanisms of Tendon Regeneration Alice Huang, PhD, Icahn School of Medicine at Mount Sinai
Cellular Basis of Tendon Regeneration Alayna Loiselle, PhD, University of Rochester Medical Center
Engineering Tissue Integration Helen H. Lu, PhD, Columbia University
2:00 PM – 4:00 PM Volleyball
7:30 PM – 8:00 PM Blue Ribbon Sun Valley Posters Chair: Alexander Robling, PhD, Indiana University
7:30 AM – 8:00 AM Ultragenyx Breakfast Session Understanding Bone Remodeling in XLH: Insight into Restoring Phosphate Homeostasis Presenter: Javier San Martin. MD
8:00 AM – 9:00 AM ASBMR/Harold M. Frost Young Investigator Awards Presentations Chair: Alexander Robling, PhD, Indiana University
9:15 AM – 12:00 PM Session: Epigenetics and Musculoskeletal Disease Session Chair: Regis J. O’Keefe, MD, PhD, Washington University
Brief Overview of Epigenetics Regis J. O’Keefe, MD, PhD, Washington University
Histone Deacetylase 3 in Cartilage Development and Osteoarthritis Jennifer J. Westendorf, PhD, Mayo Clinic:
Defining DNMT3b and Downstream Targets in the Pathogenesis of Osteoarthritis Regis J. O’Keefe, MD, PhD, Washington University
Genome-wide DNA Methylation Changes in Mice Under Simulated Microgravity Conditions Mario Fraga, University of Oviedo
1:00 PM – 2:30 PM Career Development Workshop: Bringing Discoveries to Market: Navigating the FDA Chair: Jose Moreno, PhD, FDA
The workshop will provide the audience with an overview of the various mechanisms available to obtain FDA feedback regarding the potential regulatory pathway ahead for any products resulting from their research efforts. This information is of special interest for researches applying to the Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) funding programs, where such regulatory information can have a larger impact in the funding process. Attendees will gain key knowledge regarding the current regulatory pathways for device, drug, biological and combination products, and the mechanisms available to present the results of their research efforts to FDA.
7:30 PM – 9:30 PM Session: Rare Diseases of Phosphate Handling and Tissue Mineralization: Too Much or Too Little Chair: Javier San Martin, MD, Ultragenyx, Inc.
Introduction to Phosphate Metabolism Javier San Martin, MD, Ultragenyx, Inc.
From Therapeutics Target Identification to Drug Development, with an Anti-FGF23 Antibody, Burosumab Javier San Martin, Ultragenyx, Inc.
Targeting a Unique Pathophysiology for Improved Outcomes in X-linked Hypophosphatemia Thomas Carpenter; MD, Yale University
Multiple Osteochondroma and Fibrodysplasia Ossificans Progressiva: Two Distinct Pediatric Disorders, One Common Therapeutic Target Maurizio Pacifici, PhD Children’s Hospital of Philadelphia
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