ORS PSRS 5th International Spine Research Symposium Agenda

7:30 AM – 8:30 AM
Breakfast

8:30 AM – 10:10 PM
Discussion Leaders:
Lachlan Smith, PhD, University of Pennsylvania, Philadelphia, PA
Benjamin Walter, PhD, The Ohio State University, Columbus, OH

8:30 AM – 8:40 AM
Discussion Leader Lightning Talk

8:40 AM – 9:10 AM
Engineering Biomaterial and Cell-based Strategies for Disc Regeneration- Layers of Complexity
Conor Buckley, PhD, Trinity College Dublin, Dublin, Ireland

9:10 AM – 9:40 AM
Next Generation Treatments for Disc Degeneration
Xudong Li, MD, PhD, University of Virginia, Charlottesville, VA

9:40 AM – 10:10 AM
Short Talk Podium Presentations (3, 10-minute talks, followed by discussion)

Recapitulating the Complex Biomechanical Properties of the Intervertebral Disc Using Tunable 3D Printing 
Samantha Marshall, PhD, Columbia University 

Annulus fibrosus differentiation of human bone marrow stem cells on polycaprolactone scaffolds with 3D printed oriented ply structure
Andrea Vernengo, PhD, AO Research Institute Davos 

Bioadhesive optimization and cytocompatibility assessment of a novel two-part strategy for annular repair
Tyler DiStefano, BEng, Icahn School of Medicine at Mount Sinai

10:10 AM – 10:30 AM
Break

10:30 AM – 12:10 PM
Discussion Leaders:
Sibylle Grad, PhD, AO Research Institution, Davos, Switzerland
Danny Chan, PhD, The University of Hong Kong

10:30 AM – 10:40 AM
Discussion Leader Lightning Talk

10:40 AM – 11:10 AM
Large Animal Models, Cell Therapies
Marianna Tryfonidou, DVM, PhD, Utrecht University, Utrecht, Netherlands

11:10 AM – 11:40 AM
Dogs Get Low Back Pain from Degenerative Disc Disease?
James Cook, DVM, PhD, University of Missouri, Columbia, MO

11:40 AM – 12:10 PM
Small Animal Models, Cell Therapies
Victor Leung, PhD, University of Hong Kong 

12:10 PM – 1:00 PM
Lunch

1:00 PM – 4:00 PM
Free Time (see social program)
Optional Scientific Program: ORS Spine Section/JOR Spine Histopathology and Animal Model Workshop with breakout sessions

1:00 PM – 2:00 PM
ORS Spine Section/JOR Spine – Histopathology Initiative
10-minute introductions with 5-minute discussion for each topic

• • Rat/Rabbit
  • Mouse
  • Large Animal
  • Human

2:00 PM – 3:30 PM
Breakout Discussions

• • Rat/Rabbit
  • Mouse
  • Large Animal
  • Human

4:00 PM – 4:45 PM
Odd Number Poster Viewing 

4:45 PM – 5:30 PM
Even Number Poster Viewing

5:30 PM – 6:45 PM
Dinner

7:00 PM – 9:00 PM
Session: Animal Models Working Group Recap and Tissue Cross-Talk
Discussion Leaders & JOR Spine Editors-in-Chief: Recap & working group report
Sibylle Grad, PhD, AO Research Institution, Davos, Switzerland
Danny Chan, The University of Hong Kong
Mauro Alini, PhD, AO Research Institution, Davos, Switzerland
Robert Mauck, PhD, University of Pennsylvania, Philadelphia, PA

7:00 PM – 7:10 PM
JOR Spine Update

7:10 PM – 7:20 PM
Working Group Recap Report

7:20 PM – 7:50 PM
Phlpp1 in Intervertebral Disc Degeneration
Svenja Illien-Junger, PhD, Emory University School of Medicine, Decatur, GA

7:50 PM – 8:20 PM
Pain and Organ Culture Models
Lisbet Haglund, PhD, McGill University, Montreal, QC, Canada

8:20 PM – 9:00 PM
Short Talk Podium Presentations (7 minutes each followed by group discussion)

Development of a Translational Canine Model of Human Intervertebral Disc Degeneration
Naomi Lee, DVM, University of Missouri

Structure-Function Alterations to the Vertebral Endplate during Degeneration Reduce Small Molecule Transport into the Intervertebral Disc
Beth Ashinsky, BA, University of Pennsylvania

Voluntary Running Attenuates Behavioral Low Back Pain in SPARC-Null Mice: Different Inflammatory Regulation Between Male and Female
Seunghwan Lee, PhD, McGill University

Reduced inflammation in injured tail intervertebral disc of TIPE and TIPE2-deficient mice
Yejia Zhang, MD, PhD, University of Pennsylvania

9:00 PM – 10:00 PM
Networking Reception