ORS PSRS 5th International Spine Research Symposium Agenda

2:00 PM – 9:00 PM
Arrival and Check-In

5:30 PM – 7:00 PM
Dinner

7:00 PM – 7:10 PM
Welcome/Introductory Comments by Chair
James Iatridis, PhD, Icahn School of Medicine at Mount Sinai, New York, NY

7:10 PM – 9:05 PM
Session: Diagnosis, Biomarkers & Clinical Treatment
Discussion Leaders:
Harvey Smith, MD, University of Pennsylvania, Philadelphia, PA            
James Iatridis, PhD, Icahn School of Medicine at Mount Sinai, New York, NY

7:10 PM – 7:20 PM
Discussion Leaders Lighting Talk

7:20 PM – 7:50 PM
GWAS in Low Back Pain: Phenotyping Matters
Frances Williams, MBBS, PhD, King’s College London, London, UK

7:50 PM – 8:20 PM
Clinical Pain Diagnosis
Gwen Sowa, MD, PhD, University of Pittsburgh, Pittsburgh, P

8:20 PM – 9:00 PM
Short Talk Podium Presentations (7 minutes each followed by group discussion)

Comparison of MRI Techniques as Tools to Evaluate Spinal Pathology
Morgan Giers PhD, Oregon State University

The Lasting Effects from Prolonged Microgravity on Multifidus Muscle Quality and Implications for Rehabilitation of Multifidus for Low Back Pain
Jeannie F. Bailey, PhD, University of California, San Francisco

Downregulation of Circulating miR-155 Predicts Progression of Disc Degeneration and also Correlates with Increased Leg Pain
Srikanth N. Divi, MD, Rothman Institute, Thomas Jefferson University Hospital

9:00 PM – 10:00 PM
NYC Organizing Committee Welcome Reception

7:30 AM – 8:30 AM
Breakfast

8:30 AM – 10:00 AM
Discussion Leaders:
Nadeen Chahine, PhD, Columbia University, New York, NY
Yejia Zhang, MD, PhD, University of Pennsylvania, Philadelphia, PA

8:30 AM – 8:40 AM
Discussion Leader Lighting Talk

8:40 AM – 9:10 AM
Biomarkers to Advance Clinical Phenotypes of Low Back Pain
Adam Goode, PT, DPT, PhD, Duke University, Durham, NC                                                  

9:10 AM – 9:40 AM
Phenotyping/Phenomics of Spine Imaging and Pain
Dino Samartzis, DSc, Rush University, Chicago, IL

9:40 AM – 10:00 AM
Short Talk Podium Presentations (7 minutes each followed by group discussion)

In vivo fluid Transport in Human Intervertebral Discs Varies by Spinal Level, Disc Region, and Degeneration Grade
Benjamin R. Wesorick, Duke University

Associations Between Disc Degeneration and the Mechanical and Microstructural Properties of the Vertebral Endplate (VEP)
Yuanqiao Wu, MS, Boston University

10:00 AM – 10:30 AM
Break

10:30 AM – 12:05 PM
Session: Pain Mechanisms
Discussion Leaders:
Devina Purmessur, PhD, The Ohio State University, Columbus, OH
Laura Stone, PhD, McGill University, Montreal, QC, Canada

10:30 AM – 10:40 AM
Discussion Leader Lightning Talk

10:40 AM – 11:10 AM
Mechanomodulation & Pain Mechanisms
Beth Winkelstein, PhD, University of Pennsylvania, Durham, NC

11:10 AM – 11:40 AM
Steroids and Steroid Receptors in Pain
Jun-Ming Zhang, MD, MSc, University of Cincinnati, Cincinnati, OH

11:40 AM – 12:05 PM
Short Talk Podium Presentations (7 minutes each followed by group discussion)

Peripheral Nervous System Gene Expression in Two Pain Transduction Pathways After Intervertebral Disc Injury
Grace Mosley, BS, Icahn School of Medicine at Mount Sinai 

Molecular Correlates of Pain with Disc Degeneration in Aging Mice
Kathleen Vincent, PhD, Hospital for Special Surgery

12:00 PM – 1:00 PM
Lunch

1:00 PM – 4:00 PM
Free Time (see social program)

4:00 PM – 5:30 PM
Odd Number Poster Viewing

5:30 PM – 6:30 PM
Dinner

6:30 PM – 7:00 PM
Lifetime Achievement Recipient Lecture
Michele Crites Battié, PhD, University of Western Ontario

7:00 PM – 9:00 PM
Session: Next Generation Treatments

7:00 PM – 7:10 PM
Discussion Leaders:
Lori Setton, PhD, Washington University, St. Louis, MO
Christine LeMaitre, BSc, PGCert HE, PhD, FHEA, Sheffield Hallam University, Sheffield, UK

7:10 PM – 7:40 PM
iPSCs/Stem Cells
Zulma Gazit, PhD, Cedars-Sinai Medical Center, Los Angeles, CA

7:40 PM – 8:10 PM
Disc Degeneration and Regeneration: Role of Cartilage Endplate Transport Properties
Aaron Fields, PhD, University of California San Francisco, San Francisco, CA

8:10 PM – 9:00 PM
Short Talk Podium Presentations (7 minutes each followed by group discussion)

Harmonization and Standardization of Intervertebral Disc Cell Culture Methods
Abbie Binch, PhD, Sheffield Hallam University 

Non-Viral Transfection of Human Nucleus Pulposus Cells with FOXF1 Induces Reprogramming to a Healthy Pro-anabolic Phenotype
Nina Tang, BS, The Ohio State University 

Optimized strategy for the differentiation of human induced pluripotent stem cells into notochordal-like cells: application to intervertebral disc regenerative medicine
Nicolas Vedrenne, PhD, Inserm 

Role of Cell Shape in Regulating NP Cell Phenotype
Bailey Fearing, PhD, Washington University in St. Louis

9:00 PM – 10:00 PM
Networking Reception

7:30 AM – 8:30 AM
Breakfast

8:30 AM – 10:10 PM
Discussion Leaders:
Lachlan Smith, PhD, University of Pennsylvania, Philadelphia, PA
Benjamin Walter, PhD, The Ohio State University, Columbus, OH

8:30 AM – 8:40 AM
Discussion Leader Lightning Talk

8:40 AM – 9:10 AM
Engineering Biomaterial and Cell-based Strategies for Disc Regeneration- Layers of Complexity
Conor Buckley, PhD, Trinity College Dublin, Dublin, Ireland

9:10 AM – 9:40 AM
Next Generation Treatments for Disc Degeneration
Xudong Li, MD, PhD, University of Virginia, Charlottesville, VA

9:40 AM – 10:10 AM
Short Talk Podium Presentations (3, 10-minute talks, followed by discussion)

Recapitulating the Complex Biomechanical Properties of the Intervertebral Disc Using Tunable 3D Printing 
Samantha Marshall, PhD, Columbia University 

Annulus fibrosus differentiation of human bone marrow stem cells on polycaprolactone scaffolds with 3D printed oriented ply structure
Andrea Vernengo, PhD, AO Research Institute Davos 

Bioadhesive optimization and cytocompatibility assessment of a novel two-part strategy for annular repair
Tyler DiStefano, BEng, Icahn School of Medicine at Mount Sinai

10:10 AM – 10:30 AM
Break

10:30 AM – 12:10 PM
Discussion Leaders:
Sibylle Grad, PhD, AO Research Institution, Davos, Switzerland
Danny Chan, PhD, The University of Hong Kong

10:30 AM – 10:40 AM
Discussion Leader Lightning Talk

10:40 AM – 11:10 AM
Large Animal Models, Cell Therapies
Marianna Tryfonidou, DVM, PhD, Utrecht University, Utrecht, Netherlands

11:10 AM – 11:40 AM
Dogs Get Low Back Pain from Degenerative Disc Disease?
James Cook, DVM, PhD, University of Missouri, Columbia, MO

11:40 AM – 12:10 PM
Small Animal Models, Cell Therapies
Victor Leung, PhD, University of Hong Kong 

12:10 PM – 1:00 PM
Lunch

1:00 PM – 4:00 PM
Free Time (see social program)
Optional Scientific Program: ORS Spine Section/JOR Spine Histopathology and Animal Model Workshop with breakout sessions

1:00 PM – 2:00 PM
ORS Spine Section/JOR Spine – Histopathology Initiative
10-minute introductions with 5-minute discussion for each topic

• • Rat/Rabbit
  • Mouse
  • Large Animal
  • Human

2:00 PM – 3:30 PM
Breakout Discussions

• • Rat/Rabbit
  • Mouse
  • Large Animal
  • Human

4:00 PM – 4:45 PM
Odd Number Poster Viewing 

4:45 PM – 5:30 PM
Even Number Poster Viewing

5:30 PM – 6:45 PM
Dinner

7:00 PM – 9:00 PM
Session: Animal Models Working Group Recap and Tissue Cross-Talk
Discussion Leaders & JOR Spine Editors-in-Chief: Recap & working group report
Sibylle Grad, PhD, AO Research Institution, Davos, Switzerland
Danny Chan, The University of Hong Kong
Mauro Alini, PhD, AO Research Institution, Davos, Switzerland
Robert Mauck, PhD, University of Pennsylvania, Philadelphia, PA

7:00 PM – 7:10 PM
JOR Spine Update

7:10 PM – 7:20 PM
Working Group Recap Report

7:20 PM – 7:50 PM
Phlpp1 in Intervertebral Disc Degeneration
Svenja Illien-Junger, PhD, Emory University School of Medicine, Decatur, GA

7:50 PM – 8:20 PM
Pain and Organ Culture Models
Lisbet Haglund, PhD, McGill University, Montreal, QC, Canada

8:20 PM – 9:00 PM
Short Talk Podium Presentations (7 minutes each followed by group discussion)

Development of a Translational Canine Model of Human Intervertebral Disc Degeneration
Naomi Lee, DVM, University of Missouri

Structure-Function Alterations to the Vertebral Endplate during Degeneration Reduce Small Molecule Transport into the Intervertebral Disc
Beth Ashinsky, BA, University of Pennsylvania

Voluntary Running Attenuates Behavioral Low Back Pain in SPARC-Null Mice: Different Inflammatory Regulation Between Male and Female
Seunghwan Lee, PhD, McGill University

Reduced inflammation in injured tail intervertebral disc of TIPE and TIPE2-deficient mice
Yejia Zhang, MD, PhD, University of Pennsylvania

9:00 PM – 10:00 PM
Networking Reception

7:30 AM – 8:30 AM
Breakfast

8:30 AM – 12:00 PM
Session: Biology, Development and Pathophysiology
Discussion Leaders:
Cheryle Seguin, PhD, The University of Western Ontario, London, ON Canada
Chitra Dahia, PhD, Hospital for Special Surgery, New York, NY 

8:30 AM – 8:40 AM
Discussion Leader Lightning Talk

8:40 AM – 9:10 AM
HIF-1 is the Central Regulator of NP Cell Metabolism 
Makarand Risbud, PhD, Thomas Jefferson University, Philadelphia, PA

9:10 AM – 9:40 AM
IVD Development
Rosa Serra, PhD, University of Alabama at Birmingham, Birmingham, AL

9:40 AM – 10:00 AM
Short Talk Podium Presentations (7 minutes each followed by group discussion)

Diffuse Idiopathic Skeletal Hyperostosis (DISH): Quantitative Micro-CT and Histological Analyses in Humans
Dale Fournier, MSc, The University of Western Ontario

Global Deletion of SOST Increases Osterix/Sp7 in Mildly Degenerated Intervertebral Discs
Tori Kroon, BS, IUPUI

10:00 AM -10:30 AM
Break

10:30 AM – 10:40 AM
Discussion Leader Lightning Talk 

10:40 AM – 11:30 AM
Short Talk Podium Presentations (7 minutes each followed by group discussion)

Pregnancy-associated Plasma Protein A (PappA) Knockout Mice: In Vivo Disc Study
Rebecca Kritschil, BS, University of Pittsburgh

Identification of glycomic-based therapeutics: Complete characterization of the N-glycan profile of the intervertebral disc in IVD degeneration
Kieran Joyce, National University of Ireland, Galway

Enrichment of nucleus pulposus progenitor is coupled with MEK kinase activity
Wai Kit Tam, PhD, The University of Hong Kong

Inflammatory Cytokines Induced by Sustained Loading of the Lumbar Disc is Attenuated by TRPV4 Inhibition
Garrett Easson, Masters, Washington University in St. Louis

Imaging the Local Biochemical Content of the Intervertebral Disc using Fourier Transform Infrared Microscopy
Stephen Sloan, MS, Cornell University

11:30 AM – 12:00 PM
IVD Biomaterials
Rebecca Wachs, PhD, University of Nebraska, Lincoln, NE

12:00 PM – 1:00 PM
Lunch

1:00 PM – 4:00 PM
Free Time (see social program)

4:00 PM – 5:30 PM
Even Number Poster Viewing

5:30 PM – 6:45 PM
Dinner

7:00 PM – 8:20 PM
Discussion Leaders:
Elise Morgan, PhD, Boston University, Boston, Massachusetts
Simon Tang, PhD, Washington University at St Louis, St Louis, MO

7:00 PM – 7:10 PM
Discussion Leaders Lightning Talk

7:10 PM – 7:40 PM
Biomechanical Interaction of Disc Substructures
Grace O’Connell, PhD, University of California Berkeley, Berkeley, CA

7:40 PM – 8:10 PM
CRISPR Gene Editing
Robby Bowles, PhD, University of Utah, Salt Lake City, UT

8:10 PM – 8:20 PM
ORS PSRS Awards Ceremony and Closing Remarks

Meeting adjourned

8:30 PM – 10:00 PM
ORS Spine Section Social Event 

8:00 AM – 10:00 AM
Breakfast

10:00 AM
Departure