Conference Agenda
10:00 AM – 2:00 PM
Registration
2:00 PM – 2:15 PM
Welcome and Meeting Goals
2:15 PM – 3:15 PM
Keynote Speaker: Lou Soslowsky, PhD, University of Pennsylvania
Perspectives on the Field of Tendon Research and the Roles of Decorin and Bigylcan in Tendon Structure and Function
3:30 PM – 7:00 PM
Session I: Tendon Biology
Chair: Hazel Screen, PhD, Queen Mary, University of London
Moderator: Catherine K. Kuo, PhD, University of Rochester
Speakers and Short Talks:
Hazel Screen, PhD, Queen Mary, University of London
The Tendon Interfascicular Matrix Niche
Catherine K. Kuo, PhD, University of Rochester
Embryonically Inspired Tendon Regeneration Approaches
Short Talk: Nathaniel Disser, BS, Hospital for Special Surgery
Insulin-like Growth Factor-1 Promotes Tenocyte Proliferation Through ERK1/2 Signal Transduction
Short Talk: Joohyun Lim, PhD, Baylor College of Medicine
Loss of Fkbp10 in Murine Tendons and Ligaments Recapitulates Key Features of Bruck Syndrome
Michael Kjaer, MD, DMSc, Copenhagen University
Physiological Adaptation of Tendon Collagen to Exercise
Alayna Loiselle, PhD, University of Rochester
Defining Cell Lineage, Fate and Function to Inform Tendon Therapeutics
Short Talk: Anne E.C. Nichols, PhD, Virginia-Maryland Regional College of Veterinary Medicine
Scleraxis Regulates Cytoskeletal Dynamics in Adult Tenocytes
Short Talk: Kenneth Weekes, BS, Oregon Health & Science University
Temporomandibular Joint Articular Disc: Development Guided Regeneration
7:00 PM – 9:00 PM
Networking Dinner
7:00 AM – 8:00 AM
Networking Breakfast for Hyatt House Portland/Downtown Guests
8:30 AM – 12:00 PM
Session II: Tendon Development
Chair: Jenna Galloway, PhD, Massachusetts General Hospital, Harvard Stem Cell Institute
Moderator: Ronen Schweitzer, PhD, Shriners Hospital
Speakers and Short Talks:
Jenna Galloway, PhD, Massachusetts General Hospital, Harvard Stem Cell Institute
Exploring Tendon Developmental Plasticity and Regeneration in the Zebrafish
Delphine Duprez, PhD, University Pierre et Marie Curie
Mechanical and Molecular Signals Involved in Tendon Formation
Short Talk: Deepanwita Pal, PhD, Shriners Hospital for Children
Multiple Roles of Scleraxis in Cell Recruitment and Collagen Organization at Distinct Stages of Tendon Growth
Short Talk: Dirk Hubmacher, PhD, Icahn School of Medicine at Mt. Sinai
Absence of the Extracellular Matrix Protein ADAMTSL2, Mutated in Geleophysic Dysplasia, Results in Short Tendons and Reduced Bone Length
Thomas Schilling, PhD, University of California Irvine
Mechanotransduction Regulates Tenocyte-ECM Dynamics in Zebrafish
Rui Diogo, Howard University
Evolutionary Developmental Pathology, or Macroevolutionary Medicine: A New Field of Science Bringing Together Anatomy, Human Evolution, Development, Genetics, Birth Defects and Medicine
Short Talk: Rulang Jiang, PhD, Cincinnati Children’s Hospital Medical Center
Mkx-deficient Mice Exhibit Hedgehog Signaling Dependent Heterotopic Ossification in the Achilles Tendons
Short Talk: Hiroshi Asahara, MD, PhD, The Scripps Research Institute
Mechano-signal Pathway Regulating Tendon and Ligament Via Mkx
12:00 PM -1:00 PM
Networking Lunch
1:00 PM – 3:00 PM
Poster Session
3:00 PM – 6:30 PM
Session III: Tendon Injury and Repair
Chair: Scott Rodeo, MD, Hospital of Special Surgery
Moderator: Kathleen Derwin, PhD, Cleveland Clinic
Speakers and Short Talks:
Chen-Ming Fan, PhD, Carnegie Science
Molecular and Cellular Complexity of the Patellar Tendon Sheath
Short Talk: Guak-Kim Tan, PhD, Shriners Hospitals for Children
TGF-beta Signaling is Essential for Cell Recruitment into Pathological Tendons
Hani Awad, PhD, University of Rochester
Differential Transcriptional Regulation in Models of Accelerated Tendon Repair
Short Talk: Franciele Dietrich-Zagonel, PhD, Linköping University
Corticosteroid Treatment to Improve Achilles Tendon Healing is Dose and Time Dependent
Scott Rodeo, MD, Hospital for Special Surgery
Current Status of Cell-Based Therapies for Augmentation of Tendon Repair
Short Talk: Hua Shen, PhD, Washington University
Anti-Inflammatory Effects of Stem Cell-Derived Extracellular Vesicles in the Early Phase of Tendon Healing
Short Talk: Jessica Ackerman, BS, University of Rochester Medical Center
S100a4-lineage Cells Lose S100a4 Expression to Become Alpha-SMA+ Myofibroblasts During Scar-mediated Tendon Healing
Brian Feeley, MD, University California San Francisco
Stem Cells, Fat, and Muscle Changes after Rotator Cuff Injury and Repair
6:30 PM – 8:30 PM
Networking Dinner
7:00 AM – 8:00 AM
Networking Breakfast for Hyatt House Portland/Downtown Guests
8:30 AM – 12:00 PM
Session IV: Biology and Pathology of the Enthesis
Chair: Leesa Galatz, MD, Mount Sinai Health System
Moderator: Kathleen Derwin, PhD, Cleveland Clinic
Speakers and Short Talks:
Elazar Zelzer, Weizmann Institute of Science
Enthesis Progenitors Combine the Tenogenic and Chondrogenic Genetic Programs
Short Talk: Amy Merrill, PhD, University of Southern California
Pattering Cell Fate at the Interface between Tendon and Bone
Steve Thomopoulos, PhD, Columbia University
Tendon Enthesis Development and Regeneration
Short Talk: Marie-Therese Noedl, PhD, Massachusetts General Hospital
Zebrafish as a Model of Tendon-Bone Attachment Injury and Regeneration
Xu Ca, PhD, Johns Hopkins University
TGF-β in Skeletal Tissue Homeostasis and Enthesopathy
Short Talk: Keshia Mora, BS, University of Rochester
Location-dependent Changes in Nuclear Morphology in the Achilles Tendon Due to Ankle Rotation
Short Talk: Eva Liu, MD, Brigham and Women’s Hospital
Impaired 1,25 Dihydroxyvitamin D Action Underlies Enthesopathy Development in Murine Hypophosphatemic Rickets
Leesa Galatz, MD, Mount Sinai Health System
Applying Translational Research to Rotator Cuff Repair: How Science Influences Practice
12:00 PM -1:00 PM
Networking Lunch
1:00 PM – 3:00 PM
Poster Session
3:00 PM – 6:30 PM
Session V: Tendinopathy
Chair: James Wang, PhD, University of Pittsburgh
Moderator: Peter Amadio, MD, Mayo Clinic
Speakers and Short Talks:
James Wang, PhD, University of Pittsburgh
The Role of HMGB1 in the Development of Tendinopathy
Ashlee Watts, DVM, PhD, Texas A&M University
Matrix Dysregulation in Tendinopathy
Short Talk: Adam Abraham, PhD, Columbia University
IKKβ/NF-κB Activation Drives Rotator Cuff Tendinopathy
Short Talk: Zijun Zhang, PhD, MS, Colorado State University
Expression of Estrogen Receptor and Accumulation of Advanced Glycation End-products in Tendinopathy
Vincent Wang, PhD, Virginia Tech
Assessment of Recombinant Human Hyaluronidase (rHuPH20) as a Novel Therapeutic for Tendinopathy
Andrew Carr, MDOS, University of Oxford
Improving Evidence for Tendinopathy Therapies; the role of Randomized Clinical Trials
Short Talk: Mary Frances Barbe, PhD, Temple University
Blocking CTGF/CCN2 Prevents Development of Fibrotic Tendon Changes and Motor Declines in a Rat Model of Repetitive Overuse Injury
Short Talk: Karin Gravare Silbernagel, PT, ATC, PhD
Comparison of Tendon Structure, Symptoms, and Function in Patients with Either Midportion or Insertional Achilles Tendinopathy
6:30 PM – 6:45 PM
Awards and Closing Remarks
7:00 PM – 9:00 PM
Networking Dinner
View the complete conference agenda on one page:
Thursday, November 15
10:00 AM – 2:00 PM
Registration
2:00 PM – 2:15 PM
Welcome and Meeting Goals
2:15 PM – 3:15 PM
Keynote Speaker: Lou Soslowsky, PhD, University of Pennsylvania
Perspectives on the Field of Tendon Research and the Roles of Decorin and Bigylcan in Tendon Structure and Function
3:30 PM – 7:00 PM
Session I: Tendon Biology
Chair: Hazel Screen, PhD, Queen Mary, University of London
Moderator: Catherine K. Kuo, PhD, University of Rochester
Speakers and Short Talks:
Hazel Screen, PhD, Queen Mary, University of London
The Tendon Interfascicular Matrix Niche
Catherine K. Kuo, PhD, University of Rochester
Embryonically Inspired Tendon Regeneration Approaches
Short Talk: Nathaniel Disser, BS, Hospital for Special Surgery
Insulin-like Growth Factor-1 Promotes Tenocyte Proliferation Through ERK1/2 Signal Transduction
Short Talk: Joohyun Lim, PhD, Baylor College of Medicine
Loss of Fkbp10 in Murine Tendons and Ligaments Recapitulates Key Features of Bruck Syndrome
Michael Kjaer, MD, DMSc, Copenhagen University
Physiological Adaptation of Tendon Collagen to Exercise
Alayna Loiselle, PhD, University of Rochester
Defining Cell Lineage, Fate and Function to Inform Tendon Therapeutics
Short Talk: Anne E.C. Nichols, PhD, Virginia-Maryland Regional College of Veterinary Medicine
Scleraxis Regulates Cytoskeletal Dynamics in Adult Tenocytes
Short Talk: Kenneth Weekes, BS, Oregon Health & Science University
Temporomandibular Joint Articular Disc: Development Guided Regeneration
7:00 PM – 9:00 PM
Networking Dinner
Friday, November 16
7:00 AM – 8:00 AM
Networking Breakfast for Hyatt House Portland/Downtown Guests
8:30 AM – 12:00 PM
Session II: Tendon Development
Chair: Jenna Galloway, PhD, Massachusetts General Hospital, Harvard Stem Cell Institute
Moderator: Ronen Schweitzer, PhD, Shriners Hospital
Speakers and Short Talks:
Jenna Galloway, PhD, Massachusetts General Hospital, Harvard Stem Cell Institute
Exploring Tendon Developmental Plasticity and Regeneration in the Zebrafish
Delphine Duprez, PhD, University Pierre et Marie Curie
Mechanical and Molecular Signals Involved in Tendon Formation
Short Talk: Deepanwita Pal, PhD, Shriners Hospital for Children
Multiple Roles of Scleraxis in Cell Recruitment and Collagen Organization at Distinct Stages of Tendon Growth
Short Talk: Dirk Hubmacher, PhD, Icahn School of Medicine at Mt. Sinai
Absence of the Extracellular Matrix Protein ADAMTSL2, Mutated in Geleophysic Dysplasia, Results in Short Tendons and Reduced Bone Length
Thomas Schilling, PhD, University of California Irvine
Mechanotransduction Regulates Tenocyte-ECM Dynamics in Zebrafish
Rui Diogo, Howard University
Evolutionary Developmental Pathology, or Macroevolutionary Medicine: A New Field of Science Bringing Together Anatomy, Human Evolution, Development, Genetics, Birth Defects and Medicine
Short Talk: Rulang Jiang, PhD, Cincinnati Children’s Hospital Medical Center
Mkx-deficient Mice Exhibit Hedgehog Signaling Dependent Heterotopic Ossification in the Achilles Tendons
Short Talk: Hiroshi Asahara, MD, PhD, The Scripps Research Institute
Mechano-signal Pathway Regulating Tendon and Ligament Via Mkx
12:00 PM -1:00 PM
Networking Lunch
1:00 PM – 3:00 PM
Poster Session
3:00 PM – 6:30 PM
Session III: Tendon Injury and Repair
Chair: Scott Rodeo, MD, Hospital of Special Surgery
Moderator: Kathleen Derwin, PhD, Cleveland Clinic
Speakers and Short Talks:
Chen-Ming Fan, PhD, Carnegie Science
Molecular and Cellular Complexity of the Patellar Tendon Sheath
Short Talk: Guak-Kim Tan, PhD, Shriners Hospitals for Children
TGF-beta Signaling is Essential for Cell Recruitment into Pathological Tendons
Hani Awad, PhD, University of Rochester
Differential Transcriptional Regulation in Models of Accelerated Tendon Repair
Short Talk: Franciele Dietrich-Zagonel, PhD, Linköping University
Corticosteroid Treatment to Improve Achilles Tendon Healing is Dose and Time Dependent
Scott Rodeo, MD, Hospital for Special Surgery
Current Status of Cell-Based Therapies for Augmentation of Tendon Repair
Short Talk: Hua Shen, PhD, Washington University
Anti-Inflammatory Effects of Stem Cell-Derived Extracellular Vesicles in the Early Phase of Tendon Healing
Short Talk: Jessica Ackerman, BS, University of Rochester Medical Center
S100a4-lineage Cells Lose S100a4 Expression to Become Alpha-SMA+ Myofibroblasts During Scar-mediated Tendon Healing
Brian Feeley, MD, University California San Francisco
Stem Cells, Fat, and Muscle Changes after Rotator Cuff Injury and Repair
6:30 PM – 8:30 PM
Networking Dinner
Saturday, November 17
7:00 AM – 8:00 AM
Networking Breakfast for Hyatt House Portland/Downtown Guests
8:30 AM – 12:00 PM
Session IV: Biology and Pathology of the Enthesis
Chair: Leesa Galatz, MD, Mount Sinai Health System
Moderator: Kathleen Derwin, PhD, Cleveland Clinic
Speakers and Short Talks:
Elazar Zelzer, Weizmann Institute of Science
Enthesis Progenitors Combine the Tenogenic and Chondrogenic Genetic Programs
Short Talk: Amy Merrill, PhD, University of Southern California
Pattering Cell Fate at the Interface between Tendon and Bone
Steve Thomopoulos, PhD, Columbia University
Tendon Enthesis Development and Regeneration
Short Talk: Marie-Therese Noedl, PhD, Massachusetts General Hospital
Zebrafish as a Model of Tendon-Bone Attachment Injury and Regeneration
Xu Ca, PhD, Johns Hopkins University
TGF-β in Skeletal Tissue Homeostasis and Enthesopathy
Short Talk: Keshia Mora, BS, University of Rochester
Location-dependent Changes in Nuclear Morphology in the Achilles Tendon Due to Ankle Rotation
Short Talk: Eva Liu, MD, Brigham and Women’s Hospital
Impaired 1,25 Dihydroxyvitamin D Action Underlies Enthesopathy Development in Murine Hypophosphatemic Rickets
Leesa Galatz, MD, Mount Sinai Health System
Applying Translational Research to Rotator Cuff Repair: How Science Influences Practice
12:00 PM -1:00 PM
Networking Lunch
1:00 PM – 3:00 PM
Poster Session
3:00 PM – 6:30 PM
Session V: Tendinopathy
Chair: James Wang, PhD, University of Pittsburgh
Moderator: Peter Amadio, MD, Mayo Clinic
Speakers and Short Talks:
James Wang, PhD, University of Pittsburgh
The Role of HMGB1 in the Development of Tendinopathy
Ashlee Watts, DVM, PhD, Texas A&M University
Matrix Dysregulation in Tendinopathy
Short Talk: Adam Abraham, PhD, Columbia University
IKKβ/NF-κB Activation Drives Rotator Cuff Tendinopathy
Short Talk: Zijun Zhang, PhD, MS, Colorado State University
Expression of Estrogen Receptor and Accumulation of Advanced Glycation End-products in Tendinopathy
Vincent Wang, PhD, Virginia Tech
Assessment of Recombinant Human Hyaluronidase (rHuPH20) as a Novel Therapeutic for Tendinopathy
Andrew Carr, MDOS, University of Oxford
Improving Evidence for Tendinopathy Therapies; the role of Randomized Clinical Trials
Short Talk: Mary Frances Barbe, PhD, Temple University
Blocking CTGF/CCN2 Prevents Development of Fibrotic Tendon Changes and Motor Declines in a Rat Model of Repetitive Overuse Injury
Short Talk: Karin Gravare Silbernagel, PT, ATC, PhD
Comparison of Tendon Structure, Symptoms, and Function in Patients with Either Midportion or Insertional Achilles Tendinopathy
6:30 PM – 6:45 PM
Awards and Closing Remarks
7:00 PM – 9:00 PM
Networking Dinner
