ORS 46th International Sun Valley Workshop: Musculoskeletal Biology

Solving Problems, Suggesting Solutions

Workshop Agenda

ORS 46th International Sun Valley Workshop Abstract Book

Saturday, August 6, 2016

3:00 PM – 5:30 PM (Continental Promenade)
Registration Opens

7:00 PM – 10:00 PM (Dr. Burr’s Lodge Apartment – Please inquire at the Lodge Reception Desk.)
Social Mixer

Sunday, August 7

8:00 AM – 12:00 PM (Continental Room)

The RIB Award/Plenary Session

8:00 AM – 9:00 AM
Mechanisms and Messengers in Osteocyte Regulation of Bone Biology and Pathophysiology
(RIB Awardee: Teresita Bellido, Indiana University)

9:00 AM – 9:15 AM
Break

9:15 AM – 9:45 AM
Blue Ribbon Sun Valley Posters (Three minute summary presentations)

Mechanical LINC between Nucleus and Cytoskeleton Regulates βcatenin Nuclear Access
Gunes Uzer, PhD (University of North Carolina at Chapel Hill)

The Role of Rho-ROCK Signaling in Normal and Estrogen Deficient Bone Cells in Response to Fluid Flow Induced Shear Stress
Irene Simfia, PhD (National University of Ireland Galway)

Mechanobiological Modulation of In Situ and In Vivo Osteocytic Ca2+ Oscillations in Response to Acoustic Radiation Force using Black6 and Ai38/Dmp1-Cre Mice
Minyi Hu, PhD (Stony Brook University)

Distinct Response of Osteons at Different Locations in Response to Loading and Intermittent PTH Injections
Ke Wang, PhD (Texas A&M University, Baylor College of Dentistry)

Underdevelopment of Trabecular Bone Microarchitecture in the Distal Tibia and Distal Femur of Ambulatory Children with Cerebral Palsy Becomes More Pronounced with Distance from the Growth Plate
Daniel Whitney, MS (University of Delaware)

9:45 AM – 12:00 PM
Problem: How Can We Improve Reproducibility in Pre-Clinical Models: Mouse Models?
(Chair: Gary Krishnan, Eli Lilly and Co.)

Overview and Historical Context
Gary Krishnan (Eli Lilly and Co.)

Know Thy Cells (and Antibodies): Improving Biomedical Research Reproducibility
Leonard Freedman, (President, Global Biological Standards Institute)

Improving the Reproducibility of Research Findings Using Mouse Models
Bart Williams (Van Andel Research Institute)

2:00 PM – 4:00 PM (Volleyball Court)
Volleyball

7:30 PM – 10:00 PM (Continental Room)
Poster Session with wine and cheese

7:30 – 8:00 PM
Blue Ribbon Sun Valley Posters (Five 3-minute summary presentations)

Why We Wnt to Treat Osteosarcoma
Carl Gustafson, BS (Mayo Graduate School)

Role of Phosphate in the Central Ox/Phos Metabolic Processes and Its Linkage to Collagen Production
Amira Hussein, PhD (Boston University)

Estrogen Receptor Beta (ER?) is Osteocytes: A Critical Regulator of Adult Bon Turnover and Mechanical Load-Induced Bone Formation
Russell Main, PhD (Purdue University)

Functional Adaptation of Osteocalcin and Osteopontin Deficient Mice
Stacyann Morgan, BSc (Rensselaer Polytechnic Institution)

Tibial Compression Overload Instigates Post-Traumatic Osteoarthritis in Mouse Knee
Muhammad Farooq Rai, PhD (Washington University in St. Louis)

8:00 – 10:00 PM
Poster viewing

Alice L. Jee Award Winners

Necrotic Bone Stimulates Pro-inflammatory Responses in Macrophages through the Activation of Toll-like Receptor 4
Naga Suresh Adapala, PhD (Texas Scottish Rite Hospital for Children)

FGF23 Neutralizing Antibody Ameliorates Hypophosphatemia and Impaired FGF Receptor Signaling in Kidneys of FGF2 High Molecular Weight Isoform Transgenic Mice
Erxia Du, PhD (University of Connecticut Health Center)

Why We Wnt to Treat Osteosarcoma
Carl Gustafson, BS (Mayo Graduate School)

Usp53, a Novel Target Gene of the PTH-Activated αNAC Transcriptional Coregulator
Hadla Hariri, PhD (McGill University, Shriners Hospital for Children)

Mechanobiological Modulation of In Situ and In Vivo Osteocytic Ca2+ Oscillations in Response to Acoustic Radiation Force using Black6 and Ai38/Dmp1-Cre Mice
Minyi Hu, PhD (Stony Brook University)

Role of Phosphate in the Central Ox/Phos Metabolic Processes and Its Linkage to Collagen Production
Amira Hussein, PhD (Boston University)

The Femoral and Hindlimb Skeletal Muscle Properties of G610C Osteogenesis Imperfecta Mouse Model with Soluble Activin Receptor Type IIB Fusion Proteins (ActRIIB-mFc)
Youngjae Jeong, BS (University of Missouri)

Influence of Progesterone Nuclear Receptor Signaling in Osteoprogenitor Cells on Sexual Dimorphism of Trabecular Bone Mass
Alexander Kot, BS (University of California, Davis Medical Center)

Periosteal Progenitors Contribute to Endochondral and Intramembranous Ossification in Postnatal Development
Emily Moore, MS (Columbia University)

Functional Adaptation of Osteocalcin and Osteopontin Deficient Mice
Stacyann Morgan, BSc (Rensselaer Polytechnic Institution)

Tibial Compression Overload Instigates Post-Traumatic Osteoarthritis in Mouse Knee
Muhammad Farooq Rai, PhD (Washington University in St. Louis)

Distinct Response of Osteons at Different Locations in Response to Loading and Intermittent PTH Injections
Ke Wang (Texas A&M University, Baylor College of Dentistry)

Underdevelopment of Trabecular Bone Microarchitecture in the Distal Tibia and Distal Femur of Ambulatory Children with Cerebral Palsy Becomes More Pronounced with Distance from the Growth Plate
Daniel Whitney, MS (University of Delaware)

Osteoarthritis Award Winner

A Novel Method to Assess Articular Cartilage Hydration by Raman Spectroscopy for Early Diagnosis of Osteoarthritis
Mustafa Unal, MSc (Case Western Reserve University)

Charles H. Turner Young Investigator Bone Research Award Winner

Osteoclast-selective Expression of Lrp5 HBM-causing Mutations Alters Bone Metabolism
Kang Kyung Shin, PhD (Indiana University School of Medicine)

Monday, August 8

8:00 AM – 9:45 AM
Problems in Endocrinology: How Do We Treat Bone, Muscle, and Other Target Organs in Hypophosphatasia?
(Chair: David Thompson, D. Thompson Consulting, LLC)

Introduction: How Do We Treat Bone, Muscle, and Other Affected Organs in Hypophosphatasia?
David Thompson (D. Thompson Consulting, LLC)

What We Know and Don’t Know About Hypophosphatasia
José Luis Millan, PhD (Sanford-Burnham Medical Research Institute)

Muscle Weakness in Hypophosphatasia
Michael Whyte, MD (Washington University)

9:45 AM – 10:00 AM
Break

10:00 AM – 12:00 PM
Problems in Orthopaedics: New Materials-based and Ligand-based Strategies to Stimulate Self-Repair of Tendons and Ligaments
(Chair: Michaela Kneissel, Novartis Institutes for Biomedical Research)

Overview of Tendon/Ligament Biology
Jess Snedeker, PhD (University Hospital Belgrist)

Molecular Therapies to Augment Intrinsic Tendon Repair
Olivier Leupin, PhD (Novartis Institute for Biomedical Research)

Hydrogel-based Drug Delivery
David Mooney, PhD (Harvard University)

Development of an In Vitro Model for Ligament Wound Healing
Stephanie Tuft (Boise State University)

Lesser Tuberosity Osteotomy and Subscapularis Tenotomy Repair Techniques during Total Shoulder Arthroplasty: A Meta-Analysis of Cadaveric Studies
Matthew Kraeutler (University of Colorado School of Medicine)

1:30 PM – 3:30 PM (Continental Room)
Career Development Workshop: Tenure and the Tenure Dossier
(Chair: Marjolein van der Meulen)